Search Results - "Simhadri, Vijaya"

Exposing synonymous mutations by Hunt, Ryan C, Simhadri, Vijaya L, Iandoli, Matthew, Sauna, Zuben E, Kimchi-Sarfaty, Chava

“…Highlights • Synonymous mutations, which do not result in a change in amino acid sequence, have been considered biologically silent. • Studies in molecular…”
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Prevalence of Pre-existing Antibodies to CRISPR-Associated Nuclease Cas9 in the USA Population by Simhadri, Vijaya L., McGill, Joseph, McMahon, Shane, Wang, Junxia, Jiang, Haiyan, Sauna, Zuben E.

“…The repurposing of the CRISPR/Cas microbial adaptive immune system for gene editing has resulted in an exponential rise in new technologies and promising…”
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Recent advances in (therapeutic protein) drug development by Lagassé, H A Daniel, Alexaki, Aikaterini, Simhadri, Vijaya L, Katagiri, Nobuko H, Jankowski, Wojciech, Sauna, Zuben E, Kimchi-Sarfaty, Chava

“…Therapeutic protein drugs are an important class of medicines serving patients most in need of novel therapies. Recently approved recombinant protein…”
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Endotoxin contamination in commercially available Cas9 proteins potentially induces T-cell mediated responses by Simhadri, Vijaya L., McGill, Joseph R., Sauna, Zuben E.

“…Immune responses to Cas proteins have been demonstrated recently and these may prove to be an impediment to their clinical use in gene editing. To make…”
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Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells by Simhadri, Vijaya L., Hopkins, Louis, McGill, Joseph R., Duke, Brian R., Mukherjee, Swati, Zhang, Kate, Sauna, Zuben E.

“…CRISPR–Cas9 mediated genome editing offers unprecedented opportunities for treating human diseases. There are several reports that demonstrate pre-existing…”
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Single synonymous mutation in factor IX alters protein properties and underlies haemophilia B by Simhadri, Vijaya L, Hamasaki-Katagiri, Nobuko, Lin, Brian C, Hunt, Ryan, Jha, Sujata, Tseng, Sandra C, Wu, Andrew, Bentley, Amber A, Zichel, Ran, Lu, Qi, Zhu, Lily, Freedberg, Darón I, Monroe, Dougald M, Sauna, Zuben E, Peters, Robert, Komar, Anton A, Kimchi-Sarfaty, Chava

“…Haemophilia B is caused by genetic aberrations in the gene. The majority of these are non-synonymous mutations that alter the primary structure of blood…”
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Small ncRNA Expression-Profiling of Blood from Hemophilia A Patients Identifies miR-1246 as a Potential Regulator of Factor 8 Gene by Sarachana, Tewarit, Dahiya, Neetu, Simhadri, Vijaya L, Pandey, Gouri Shankar, Saini, Surbhi, Guelcher, Christine, Guerrera, Michael F, Kimchi-Sarfaty, Chava, Sauna, Zuben E, Atreya, Chintamani D

“…Hemophilia A (HA) is a bleeding disorder caused by deficiency of functional plasma clotting factor VIII (FVIII). Genetic mutations in the gene encoding FVIII…”
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A structural homology approach to identify potential cross-reactive antibody responses following SARS-CoV-2 infection by McGill, Joseph R., Lagassé, H. A. Daniel, Hernandez, Nancy, Hopkins, Louis, Jankowski, Wojciech, McCormick, Quinn, Simhadri, Vijaya, Golding, Basil, Sauna, Zuben E.

“…The emergence of the novel SARS-CoV-2 virus is the most important public-health issue of our time. Understanding the diverse clinical presentations of the…”
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HLA Variants and Inhibitor Development in Hemophilia A: A Retrospective Case-Controlled Study Using the ATHNdataset by McGill, Joseph R., Simhadri, Vijaya L., Sauna, Zuben E.

“…In hemophilia A (HA) patients, F8 gene-defects as genetic risk-factors for developing inhibitors to Factor VIII have been extensively studied. Here we provide…”
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Corrigendum to “Computational design of nanomolar-binding antibodies specific to multiple SARS-CoV-2 variants by engineering a specificity switch of antibody 80R using RosettaAntibodyDesign (RAbD) results in potential generalizable therapeutic antibodies for novel SARS-CoV-2 virus” [Heliyon 9(4) (April 2023) e15032] by Hernandez, Nancy E., Jankowski, Wojciech, Frick, Rahel, Kelow, Simon P., Lubin, Joseph H., Simhadri, Vijaya, Adolf-Bryfogle, Jared, Khare, Sagar D., Dunbrack, Roland L., Gray, Jeffrey J., Sauna, Zuben E.

“…[This corrects the article DOI: 10.1016/j.heliyon.2023.e15032.]…”
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Computational design of nanomolar-binding antibodies specific to multiple SARS-CoV-2 variants by engineering a specificity switch of antibody 80R using RosettaAntibodyDesign (RAbD) results in potential generalizable therapeutic antibodies for novel SARS-CoV-2 virus by Hernandez, Nancy E., Jankowski, Wojciech, Frick, Rahel, Kelow, Simon P., Lubin, Joseph H., Simhadri, Vijaya, Adolf-Bryfogle, Jared, Khare, Sagar D., Dunbrack, Roland L., Gray, Jeffrey J., Sauna, Zuben E.

“…The human infectious disease COVID-19 caused by the SARS-CoV-2 virus has become a major threat to global public health. Developing a vaccine is the preferred…”
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Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function by Simhadri, Venkateswara Rao, Reiners, Katrin S, Hansen, Hinrich P, Topolar, Daniela, Simhadri, Vijaya Lakshmi, Nohroudi, Klaus, Kufer, Thomas A, Engert, Andreas, Pogge von Strandmann, Elke

“…NKp30, a natural cytotoxicity receptor expressed on NK cells is critically involved in direct cytotoxicity against various tumor cells and directs both…”
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Cyclosporin A Impairs the Secretion and Activity of ADAMTS13 (A Disintegrin and Metalloprotease with Thrombospondin Type 1 Repeat) by Hershko, Klilah, Simhadri, Vijaya L., Blaisdell, Adam, Hunt, Ryan C., Newell, Jordan, Tseng, Sandra C., Hershko, Alon Y., Choi, Jae Won, Sauna, Zuben E., Wu, Andrew, Bram, Richard J., Komar, Anton A., Kimchi-Sarfaty, Chava

“…The protease ADAMTS13 (adisintegrin and metalloprotease with thrombospondin type 1 repeat) cleaves multimers of von Willebrand factor, thus regulating platelet…”
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Human Leukocyte Antigen-B-Associated Transcript 3 Is Released from Tumor Cells and Engages the NKp30 Receptor on Natural Killer Cells by Pogge von Strandmann, Elke, Simhadri, Venkateswara Rao, von Tresckow, Bastian, Sasse, Stephanie, Reiners, Katrin S., Hansen, Hinrich P., Rothe, Achim, Böll, Boris, Simhadri, Vijaya Lakshmi, Borchmann, Peter, McKinnon, Peter J., Hallek, Michael, Engert, Andreas

“…The activity of natural killer (NK) cells is regulated by surface receptors, which direct target cell recognition. NKp30 (Natural Cytotoxicity Receptor 3)…”
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Single‐nucleotide variations defining previously unreported ADAMTS13 haplotypes are associated with differential expression and activity of the VWF‐cleaving protease in a Salvadoran congenital thrombotic thrombocytopenic purpura family by Kim, Benjamin, Hing, Zachary A., Wu, Andrew, Schiller, Tal, Struble, Evi B., Liuwantara, David, Kempert, Pamela H., Broxham, Eric J., Edwards, Nathan C., Marder, Victor J., Simhadri, Vijaya L., Sauna, Zuben E., Howard, Tom E., Kimchi‐Sarfaty, Chava

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Archaeal and bacteriophage derived Cas proteins demonstrate memory T cell response in humans by Bajgain, Pratima, Sauna, Zuben E, Simhadri, Vijaya

“…The CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas system is a powerful gene editing tool with clinical applications in the pipeline…”
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A novel role for reciprocal CD30-CD30L signaling in the cross-talk between natural killer and dendritic cells by Simhadri, Vijaya Lakshmi, Hansen, Hinrich P, Simhadri, Venkateswara R, Reiners, Katrin S, Bessler, Martina, Engert, Andreas, von Strandmann, Elke Pogge

“…The interplay between dendritic cells (DCs) and natural killer (NK) cells directs adaptive immune responses. The molecular basis of the cross-talk is largely…”
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A structural homology approach to identify potential cross-reactive antibody responses following SARS-CoV-2 infection by McGill, Joseph R., Lagassé, H. A. Daniel, Hernandez, Nancy, Hopkins, Louis, Jankowski, Wojciech, McCormick, Quinn, Simhadri, Vijaya, Golding, Basil, Sauna, Zuben E.

“…Abstract The emergence of the novel SARS-CoV-2 virus is the most important public-health issue of our time. Understanding the diverse clinical presentations of…”
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Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies by Alexaki, Aikaterini, Hettiarachchi, Gaya K., Athey, John C., Katneni, Upendra K., Simhadri, Vijaya, Hamasaki-Katagiri, Nobuko, Nanavaty, Puja, Lin, Brian, Takeda, Kazuyo, Freedberg, Darón, Monroe, Dougald, McGill, Joseph R., Peters, Robert, Kames, Jacob M., Holcomb, David D., Hunt, Ryan C., Sauna, Zuben E., Gelinas, Amy, Janjic, Nebojsa, DiCuccio, Michael, Bar, Haim, Komar, Anton A., Kimchi-Sarfaty, Chava

“…Synonymous codons occur with different frequencies in different organisms, a phenomenon termed codon usage bias. Codon optimization, a common term for a…”
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Protrusion-guided extracellular vesicles mediate CD30 trans-signalling in the microenvironment of Hodgkin's lymphoma by Hansen, Hinrich P, Engels, Hanna-Mareike, Dams, Maria, Paes Leme, Adriana F, Pauletti, Bianca Alves, Simhadri, Vijaya Lakshmi, Dürkop, Horst, Reiners, Katrin S, Barnert, Sabine, Engert, Andreas, Schubert, Rolf, Quondamatteo, Fabio, Hallek, Michael, Pogge von Strandmann, Elke

“…Classical Hodgkin's lymphoma (cHL)‐affected lymphoid tissue contains only a few malignant Hodgkin and Reed–Sternberg (HRS) cells, which are disseminated within…”
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