Search Results - "Simhadri, R. R."

Quantitative biodistribution of nanoparticles in plants with lanthanide complexes by Hou, H., Xu, Z., Takeda, Y. S., Powers, M., Yang, Y., Hershberger, K., Hanscom, Hailey, Svenson, S., Simhadri, R. K., Vegas, A. J.

“…The inefficient distribution of fertilizers, nutrients, and pesticides on crops is a major challenge in modern agriculture that leads to reduced productivity…”
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The Biology and Disease Relevance of CD300a, an Inhibitory Receptor for Phosphatidylserine and Phosphatidylethanolamine by Zenarruzabeitia, Olatz, Vitallé, Joana, Eguizabal, Cristina, Simhadri, Venkateswara R, Borrego, Francisco

“…The CD300a inhibitory receptor belongs to the CD300 family of cell surface molecules that regulate a diverse array of immune cell processes. The inhibitory…”
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Dynamics of single droplet impact on cylindrically-curved superheated surfaces by Simhadri Rajesh, R., Naveen, P.T., Krishnakumar, K., Kumar Ranjith, S.

“…Liquid droplet impact on superheated symmetric surfaces such as flat and spherical geometries has been extensively investigated in the past. However, the…”
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Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity by Reiners, Katrin S., Topolar, Daniela, Henke, Alexander, Simhadri, Venkateswara R., Kessler, Jörg, Sauer, Maike, Bessler, Martina, Hansen, Hinrich P., Tawadros, Samir, Herling, Marco, Krönke, Martin, Hallek, Michael, Pogge von Strandmann, Elke

“…Natural killer (NK) cells are a major component of the anti-tumor immune response. NK cell dysfunctions have been reported in various hematologic malignancies,…”
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Simultaneous Effect of Droplet Temperature and Surface Wettability on Single Drop Impact Dynamics by Naveen, P. T., Simhadri, R. R., Ranjith, S. K.

“…In this paper, the influence of the liquid droplet temperature on thermo–hydrodynamics of a single droplet impinging on surfaces having different…”
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Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells by Simhadri, Venkateswara R., Andersen, John F., Calvo, Eric, Choi, Seung-Chul, Coligan, John E., Borrego, Francisco

“…CD300a is an immunoreceptor tyrosine-based inhibitory motif (ITIM) containing molecule that belongs to the CD300 family of paired activating/inhibitory…”
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A Human Anti-M2 Antibody Mediates Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Cytokine Secretion by Resting and Cytokine-Preactivated Natural Killer (NK) Cells by Simhadri, Venkateswara R, Dimitrova, Milena, Mariano, John L, Zenarruzabeitia, Olatz, Zhong, Weimin, Ozawa, Tatsuhiko, Muraguchi, Atsushi, Kishi, Hiroyuki, Eichelberger, Maryna C, Borrego, Francisco

“…The highly conserved matrix protein 2 (M2) is a good candidate for the development of a broadly protective influenza vaccine that induces long-lasting…”
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CD300c is uniquely expressed on CD56bright Natural Killer Cells and differs from CD300a upon ligand recognition by Dimitrova, Milena, Zenarruzabeitia, Olatz, Borrego, Francisco, Simhadri, Venkateswara R.

“…Paired receptors on NK cells recognize similar ligands with varied strength of binding ability and perform different functions. The CD300 molecules are…”
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Cutting edge: mouse CD300f (CMRF-35-like molecule-1) recognizes outer membrane-exposed phosphatidylserine and can promote phagocytosis by Choi, Seung-Chul, Simhadri, Venkateswara R, Tian, Linjie, Gil-Krzewska, Aleksandra, Krzewski, Konrad, Borrego, Francisco, Coligan, John E

“…Reportedly, CD300f negatively regulates interactions between dendritic and T cells and acts as an anti-inflammatory molecule in a multiple sclerosis mouse…”
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The expression and function of human CD300 receptors on blood circulating mononuclear cells are distinct in neonates and adults by Zenarruzabeitia, Olatz, Vitallé, Joana, García-Obregón, Susana, Astigarraga, Itziar, Eguizabal, Cristina, Santos, Silvia, Simhadri, Venkateswara R., Borrego, Francisco

“…Neonates are more susceptible to infections than adults. This susceptibility is thought to reflect neonates’ qualitative and quantitative defects in the…”
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CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection by Silva, Rodolfo, Moir, Susan, Kardava, Lela, Debell, Karen, Simhadri, Venkateswara R., Ferrando-Martínez, Sara, Leal, Manuel, Peña, José, Coligan, John E., Borrego, Francisco

“…The immunomodulatory receptor CD300a is expressed on human B cells. Naive B cells express very low levels of this receptor, whereas memory B cells and…”
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Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin by Narayanan, Sriram, Silva, Rodolfo, Peruzzi, Giovanna, Alvarez, Yelina, Simhadri, Venkateswara R, Debell, Karen, Coligan, John E, Borrego, Francisco

“…Human naïve CD4 T cells express low levels of the immunomodulatory receptor CD300a, whereas effector/memory CD4 cells can be either CD300a(+) or CD300a(-)…”
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Intact IL-12 signaling is necessary for the generation of human natural killer cells with enhanced effector function after restimulation by Simhadri, Venkateswara R., PhD, Mariano, John L., BS, Zenarruzabeitia, Olatz, PhD, Seroogy, Christine M., MD, Holland, Steven M., MD, Kuehn, Hye Sun, PhD, Rosenzweig, Sergio D., MD, PhD, Borrego, Francisco, MD, PhD

“…[...]our results are in accordance with those obtained with the mouse cytomegalovirus infection model, which demonstrated that degranulation by mouse memory NK…”
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Heat Shock Protein 90 Inhibitor BIIB021 (CNF2024) Depletes NF-κB and Sensitizes Hodgkin's Lymphoma Cells for Natural Killer Cell–Mediated Cytotoxicity by BÖLL, Boris, ELTAIB, Farag, VON STRANDMANN, Elke Pogge, REINERS, Katrin S, VON TRESCKOW, Bastian, TAWADROS, Samir, SIMHADRI, Venkateswara R, BURROWS, Francis J, LUNDGREN, Karen, HANSEN, Hinrich P, ENGERT, Andreas

“…Purpose: In Hodgkin's lymphoma, constitutive activation of NF-κB promotes tumor cell survival and proliferation. The molecular chaperone heat shock protein 90…”
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CD300c is an Activating Receptor Expressed on Human Monocytes by Simhadri, Venkateswara R., Mariano, John L., Gil-Krzewska, Aleksandra, Zhou, Qing, Borrego, Francisco

“…Human CD300 molecules comprise a family of receptors that regulate many immune cell processes. They are mostly expressed on myeloid cells, although expression…”
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A novel role for reciprocal CD30-CD30L signaling in the cross-talk between natural killer and dendritic cells by Simhadri, Vijaya Lakshmi, Hansen, Hinrich P, Simhadri, Venkateswara R, Reiners, Katrin S, Bessler, Martina, Engert, Andreas, von Strandmann, Elke Pogge

“…The interplay between dendritic cells (DCs) and natural killer (NK) cells directs adaptive immune responses. The molecular basis of the cross-talk is largely…”
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A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo by von Strandmann, Elke Pogge, Hansen, Hinrich P., Reiners, Katrin S., Schnell, Roland, Borchmann, Peter, Merkert, Sabine, Simhadri, Venkateswara R., Draube, Andreas, Reiser, Marcel, Purr, Ingvill, Hallek, Michael, Engert, Andreas

“…The inability of the immune system to recognize and kill malignant plasma cells in patients with multiple myeloma (MM) has been attributed in part to the…”
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Functional requirements for inhibitory signal transmission by the immunomodulatory receptor CD300a by DeBell, Karen E, Simhadri, Venkateswara R, Mariano, John L, Borrego, Francisco

“…Activation signals can be negatively regulated by cell surface receptors bearing immunoreceptor tyrosine-based inhibitory motifs (ITIMs). CD300a, an ITIM…”
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Differential expression of CD300a/c on human TH1 and TH17 cells by Simhadri, Venkateswara R, Mariano, John L, Zhou, Qing, DeBell, Karen E, Borrego, Francisco

“…Human memory CD4+ T cells can be either CD300a/c+ or CD300a/c- and subsequent analyses showed that CD4+ effector memory T (T(EM)) cells are mostly CD300a/c+,…”
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TNF-α-converting enzyme (TACE ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species by Vahdat, A M, Reiners, K S, Simhadri, V L, Eichenauer, D A, Böll, B, Chalaris, A, Simhadri, V R, Wiegmann, K, Krell, H-W, Rose-John, S, Engert, A, von Strandmann, E P, Hansen, H P

“…Combinations with proteasome inhibitors are currently being investigated to improve the therapy of hematological malignancies. We previously found that…”
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