Search Results - "Simeonov, P."

Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states by Simeonov, Kamen P., Byrns, China N., Clark, Megan L., Norgard, Robert J., Martin, Beth, Stanger, Ben Z., Shendure, Jay, McKenna, Aaron, Lengner, Christopher J.

“…The underpinnings of cancer metastasis remain poorly understood, in part due to a lack of tools for probing their emergence at high resolution. Here we present…”
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Direct reprogramming of human fibroblasts to hepatocyte-like cells by synthetic modified mRNAs by Simeonov, Kamen P, Uppal, Hirdesh

“…Direct reprogramming by overexpression of defined transcription factors is a promising new method of deriving useful but rare cell types from readily available…”
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Production and Synthetic Modifications of Shikimic Acid by Candeias, Nuno R, Assoah, Benedicta, Simeonov, Svilen P

“…Shikimic acid is a natural product of industrial importance utilized as a precursor of the antiviral Tamiflu. It is nowadays produced in multihundred ton…”
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Biorefinery via Achmatowicz Rearrangement: Synthesis of Pentane‐1,2,5‐triol from Furfuryl Alcohol by Simeonov, Svilen P., Ravutsov, Martin A., Mihovilovic, Marko D.

“…A new scalable synthesis of pentane‐1,2,5‐triol from the furanics platform has been developed. Excellent yields of up to 92 % are obtained under flow…”
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Amidoalkyl Naphthols as Important Bioactive Substances and Building Blocks: A Review on the Current Catalytic Mannich-Type Synthetic Approaches by Petkov, Hristo, Simeonov, Svilen P

“…Currently, 1-amidoalkyl-2-naphthol derivatives are of increasing interest due to their biological activities and further use in the preparation of other…”
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Going Beyond the Limits of the Biorenewable Platform: Sodium Dithionite‐Promoted Stabilization of 5‐Hydroxymethylfurfural by Gomes, Rafael F. A., Mitrev, Yavor N., Simeonov, Svilen P., Afonso, Carlos A. M.

“…The lack of thermal and storage stability and occurrence of side reactions during the processing of 5‐hydroxymethylfurfural (5‐HMF) limits its potential as…”
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Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells by Yousefi, Maryam, Nakauka-Ddamba, Angela, Berry, Corbett T., Li, Ning, Schoenberger, Jenna, Bankler-Jukes, Devon, Simeonov, Kamen P., Cedeno, Ryan J., Yu, Zhengquan, Lengner, Christopher J.

“…Aging is a complex process associated with a decline in functionality of adult stem cells affecting tissue homeostasis and regeneration. Calorie restriction…”
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Creating Diversity from Biomass: A Tandem Bio/Metal‐Catalysis towards Chemoselective Synthesis of Densely Substituted Furans by Ravasco, João M. J. M., Monteiro, Carlos M., Siopa, Filipa, Trindade, Alexandre F., Oble, Julie, Poli, Giovanni, Simeonov, Svilen P., Afonso, Carlos A. M.

“…A new chemoselective (enzymatic desymmetrization/Ru‐catalyzed C−H activation) sequence to obtain differently substituted furans from the largely available…”
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Functional Nanogel from Natural Substances for Delivery of Doxorubicin by Kamenova, Katya, Radeva, Lyubomira, Yoncheva, Krassimira, Ublekov, Filip, Ravutsov, Martin A., Marinova, Maya K., Simeonov, Svilen P., Forys, Aleksander, Trzebicka, Barbara, Petrov, Petar D.

“…Nanogels (NGs) have attracted great attention because of their outstanding biocompatibility, biodegradability, very low toxicity, flexibility, and softness…”
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Biorenewable Oxypropylated Pentane-1,2,5-triol as a Source for Incorporation in Rigid Polyurethane Foams by Grancharov, Georgy, Atanasova, Mariya-Desislava, Kalinova, Radostina, Tuleshkov, Pencho, Petrov, Petar D., Marinova, Maya K., Ravutsov, Martin A., Simeonov, Svilen P.

“…In this study, as a product from the efficient Achmatowicz rearrangement and mild subsequent hydrogenation–reduction reactions of biorenewable C5 alcohols…”
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Separation performance of CO2 through Supported Magnetic Ionic Liquid Membranes (SMILMs) by Albo, J., Santos, E., Neves, L.A., Simeonov, S.P., Afonso, C.A.M., Crespo, J.G., Irabien, A.

“…► CO2 separation using Supported Magnetic Ionic Liquid Membranes (SMILMs) is studied. ► Membrane stability, gas permeability and selectivity towards CO2 is…”
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Balloon expandable vs. self-expandable transcatheter aortic valve prosthesis short-term results of retrospective study by Angelov, Hr, Simeonov, P, Krastev, P, Abedinov, F, Jorgova, J, Trendafilova, D

“…Transcutaneous aortic valve implantation has been established as an effective method for the treatment of highgrade aortic stenosis in non-operative, high-risk…”
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An Integrated Approach for the Production and Isolation of 5-Hydroxymethylfurfural from Carbohydrates by Simeonov, Svilen P, Coelho, Jaime A S, Afonso, Carlos A M

“…Crystal clear: An integrated, simple, efficient, reusable, and scalable methodology for the dehydration of fructose to HMF offers outstanding yields and high…”
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Site-Selective C–H Functionalization of Arenes Enabled by Noncovalent Interactions by Fernández-Figueiras, Adolfo, Ravutsov, Martin A, Simeonov, Svilen P

“…The direct metal-catalyzed C–H functionalization of arenes has emerged as a powerful tool for streamlining the synthesis of complex molecular scaffolds…”
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Lung cancer incidence decreases with elevation: evidence for oxygen as an inhaled carcinogen by Simeonov, Kamen P, Himmelstein, Daniel S

“…The level of atmospheric oxygen, a driver of free radical damage and tumorigenesis, decreases sharply with rising elevation. To understand whether ambient…”
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TAVI in bicuspid aortic valve by Dimitrova, I.N., Jorgova, J., Simeonov, P., Angelov, H., Trendafilova, D.

“…Transcatheter aortic valve implantation (TAVI) is an established choice for the treatment of severe aortic stenosis (AS) in patients who are deemed inoperable…”
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Incorporation of Resveratrol in Polymeric Nanogel for Improvement of Its Protective Effects on Cellular and Microsomal Oxidative Stress Models by Radeva, Lyubomira, Stefanova, Denitsa, Yordanov, Yordan, Kamenova, Katya, Petrov, Petar D, Marinova, Maya K, Simeonov, Svilen P, Kondeva-Burdina, Magdalena, Tzankova, Virginia, Yoncheva, Krassimira

“…Nanogels are attractive drug delivery systems that provide high loading capacity for drug molecules, improve their stability, and increase cellular uptake…”
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Postural stability effects of random vibration at the feet of construction workers in simulated elevation by Simeonov, P., Hsiao, H., Powers, J., Ammons, D., Kau, T., Amendola, A.

“…The risk of falls from height on a construction site increases under conditions which degrade workers’ postural control. At elevation, workers depend heavily…”
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The predictive role of fully revascularized coronary artery disease in patients undergoing transaortic valve implantation by Pencheva, R, Shabani, J, Trendafilova, D, Jorgova, J, Angelov, H, Simeonov, P, Dimitrova, I

“…In the modern days and the era of the rapid development of medical technology, the introduction of innovative invasive methods of treatment is gradually…”
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Functional Hydrogels for Delivery of the Proteolytic Enzyme Serratiopeptidase by Kamenova, Katya, Prancheva, Anna, Stoyanova, Stiliyana, Radeva, Lyubomira, Tibi, Ivanka Pencheva-El, Yoncheva, Krassimira, Ravutsov, Martin A, Marinova, Maya K, Simeonov, Svilen P, Mitova, Simona, Eneva, Rumyana, Zaharieva, Maya M, Najdenski, Hristo, Petrov, Petar D

“…Hydrogels are superior wound dressings because they can provide protection and hydration of the wound, as well as the controlled release of therapeutic…”
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