Search Results - "Simeone, Xenia"

A novel de novo variant of GABRA1 causes increased sensitivity for GABA in vitro by Steudle, Friederike, Rehman, Sabah, Bampali, Konstantina, Simeone, Xenia, Rona, Zsofia, Hauser, Erwin, Schmidt, Wolfgang M., Scholze, Petra, Ernst, Margot

“…The GABRA1 gene encodes one of the most conserved and highly expressed subunits of the GABA A receptor family. Variants in this gene are causatively implicated…”
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Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What? by Puthenkalam, Roshan, Hieckel, Marcel, Simeone, Xenia, Suwattanasophon, Chonticha, Feldbauer, Roman V, Ecker, Gerhard F, Ernst, Margot

“…Atomic resolution structures of cys-loop receptors, including one of a γ-aminobutyric acid type A receptor (GABAA receptor) subtype, allow amazing insights…”
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GABAA Receptor Ligands Often Interact with Binding Sites in the Transmembrane Domain and in the Extracellular Domain—Can the Promiscuity Code Be Cracked? by Iorio, Maria Teresa, Vogel, Florian Daniel, Koniuszewski, Filip, Scholze, Petra, Rehman, Sabah, Simeone, Xenia, Schnürch, Michael, Mihovilovic, Marko D., Ernst, Margot

“…Many allosteric binding sites that modulate gamma aminobutyric acid (GABA) effects have been described in heteropentameric GABA type A (GABAA) receptors, among…”
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Molecular tools for GABAA receptors: High affinity ligands for β1-containing subtypes by Simeone, Xenia, Siebert, David C. B., Bampali, Konstantina, Varagic, Zdravko, Treven, Marco, Rehman, Sabah, Pyszkowski, Jakob, Holzinger, Raphael, Steudle, Friederike, Scholze, Petra, Mihovilovic, Marko D., Schnürch, Michael, Ernst, Margot

“…γ-Aminobutyric acid type A (GABA A ) receptors are pentameric GABA-gated chloride channels that are, in mammalians, drawn from a repertoire of 19 different…”
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The role of the nAChR subunits α5, β2, and β4 on synaptic transmission in the mouse superior cervical ganglion by Simeone, Xenia, Karch, Rudolf, Ciuraszkiewicz, Anna, Orr‐Urtreger, Avi, Lemmens‐Gruber, Rosa, Scholze, Petra, Huck, Sigismund

“…Our previous immunoprecipitation analysis of nicotinic acetylcholine receptors (nAChRs) in the mouse superior cervical ganglion (SCG) revealed that…”
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α subunits in GABAA receptors are dispensable for GABA and diazepam action by Wongsamitkul, Nisa, Maldifassi, Maria C., Simeone, Xenia, Baur, Roland, Ernst, Margot, Sigel, Erwin

“…The major isoform of the GABA A receptor is α 1 β 2 γ 2 . The binding sites for the agonist GABA are located at the β 2 +/α 1 − subunit interfaces and the…”
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A Benzodiazepine Ligand with Improved GABA A Receptor α 5-Subunit Selectivity Driven by Interactions with Loop C by Simeone, Xenia, Koniuszewski, Filip, Müllegger, Markus, Smetka, Andreas, Steudle, Friederike, Puthenkalam, Roshan, Ernst, Margot, Scholze, Petra

“…The family of GABA receptors is an important drug target group in the treatment of sleep disorders, anxiety, epileptic seizures, and many others. The most…”
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Novel alpha6 preferring GABA-A receptor ligands based on loreclezole by Simeone, Xenia, Ernst, Margot, Seidel, Thomas, Heider, Joerg, Enz, Doris, Monticelli, Serena, Vogel, Florian Daniel, Koniuszewski, Filip, Langer, Thierry, Scholze, Petra, Pace, Vittorio, Miele, Margherita

“…The family of GABA-A receptors contains nineteen mammalian subunits from which pentameric, GABA gated anion channels are assembled. The subunit encoded by the…”
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GABA A Receptor Ligands Often Interact with Binding Sites in the Transmembrane Domain and in the Extracellular Domain-Can the Promiscuity Code Be Cracked? by Iorio, Maria Teresa, Vogel, Florian Daniel, Koniuszewski, Filip, Scholze, Petra, Rehman, Sabah, Simeone, Xenia, Schnürch, Michael, Mihovilovic, Marko D, Ernst, Margot

“…Many allosteric binding sites that modulate gamma aminobutyric acid (GABA) effects have been described in heteropentameric GABA type A (GABA ) receptors, among…”
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Allosteric Modulation of GABA A Receptors in Rat Basolateral Amygdala Blocks Stress-Enhanced Reacquisition of Nicotine Self-Administration by Sharp, Burt M, Jiang, Qin, Simeone, Xenia, Scholze, Petra

“…Stress is a major determinant of relapse to smoked tobacco. In a rat model, repeated stress during abstinence from nicotine self-administration (SA) results in…”
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Allosteric Modulation of GABAA Receptors in Rat Basolateral Amygdala Blocks Stress-Enhanced Reacquisition of Nicotine Self-Administration by Sharp, Burt M, Jiang, Qin, Simeone, Xenia, Scholze, Petra

“…Stress is a major determinant of relapse to smoked tobacco. In a rat model, repeated stress during abstinence from nicotine self-administration (SA) results in…”
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Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes by David, Reinhard, Ciuraszkiewicz, Anna, Simeone, Xenia, Orr-Urtreger, Avi, Papke, Roger L., McIntosh, J. M., Huck, Sigismund, Scholze, Petra

“…Nicotinic acetylcholine receptors (nAChRs) mediate fast synaptic transmission in ganglia of the autonomic nervous system. Here, we determined the subunit…”
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The role of the nAChR subunits α 5, β 2, and β 4 on synaptic transmission in the mouse superior cervical ganglion by Simeone, Xenia, Karch, Rudolf, Ciuraszkiewicz, Anna, Orr‐Urtreger, Avi, Lemmens‐Gruber, Rosa, Scholze, Petra, Huck, Sigismund

“…Our previous immunoprecipitation analysis of nicotinic acetylcholine receptors (nAChRs) in the mouse superior cervical ganglion (SCG) revealed that…”
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Mating-induced transient inhibition of responses to sex pheromone in a male moth is not mediated by octopamine or serotonin by Barrozo, Romina B, Jarriault, David, Simeone, Xenia, Gaertner, Cyril, Gadenne, Christophe, Anton, Sylvia

“…In the male moth, Agrotis ipsilon, mating induces a transient inhibition of behavioural and central nervous responses to sex pheromone. Newly mated males are…”
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α subunits in GABA A receptors are dispensable for GABA and diazepam action by Wongsamitkul, Nisa, Maldifassi, Maria C, Simeone, Xenia, Baur, Roland, Ernst, Margot, Sigel, Erwin

“…The major isoform of the GABA receptor is α β γ . The binding sites for the agonist GABA are located at the β +/α - subunit interfaces and the modulatory site…”
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Molecular tools for GABA A receptors: High affinity ligands for β1-containing subtypes by Simeone, Xenia, Siebert, David C B, Bampali, Konstantina, Varagic, Zdravko, Treven, Marco, Rehman, Sabah, Pyszkowski, Jakob, Holzinger, Raphael, Steudle, Friederike, Scholze, Petra, Mihovilovic, Marko D, Schnürch, Michael, Ernst, Margot

“…γ-Aminobutyric acid type A (GABA ) receptors are pentameric GABA-gated chloride channels that are, in mammalians, drawn from a repertoire of 19 different…”
Get full text