Search Results - "Simeone, M"

Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes by Kanwar, Shailender Singh, Dunlay, Christopher James, Simeone, Diane M, Nagrath, Sunitha

“…Membrane bound vesicles, including microvesicles and exosomes, are secreted by both normal and cancerous cells into the extracellular space and in blood…”
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Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas by Moncada, Reuben, Barkley, Dalia, Wagner, Florian, Chiodin, Marta, Devlin, Joseph C., Baron, Maayan, Hajdu, Cristina H., Simeone, Diane M., Yanai, Itai

“…Single-cell RNA sequencing (scRNA-seq) enables the systematic identification of cell populations in a tissue, but characterizing their spatial organization…”
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Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells by Wan, Shanshan, Zhao, Ende, Kryczek, Ilona, Vatan, Linda, Sadovskaya, Anna, Ludema, Gregory, Simeone, Diane M, Zou, Weiping, Welling, Theodore H

“…Background & Aims Cancer stem cells (CSCs) can contribute to hepatocellular carcinoma (HCC) progression and recurrence after therapy. The presence of…”
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Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma by Grossberg, Aaron J., Chu, Linda C., Deig, Christopher R., Fishman, Eliot K., Hwang, William L., Maitra, Anirban, Marks, Daniel L., Mehta, Arnav, Nabavizadeh, Nima, Simeone, Diane M., Weekes, Colin D., Thomas, Charles R.

“…Despite tremendous gains in the molecular understanding of exocrine pancreatic cancer, the prognosis for this disease remains very poor, largely because of…”
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SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models by Fedele, Carmine, Ran, Hao, Diskin, Brian, Wei, Wei, Jen, Jayu, Geer, Mitchell J, Araki, Kiyomi, Ozerdem, Ugur, Simeone, Diane M, Miller, George, Neel, Benjamin G, Tang, Kwan Ho

“…Adaptive resistance to MEK inhibitors (MEKi) typically occurs via induction of genes for different receptor tyrosine kinases (RTK) and/or their ligands, even…”
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Evaluating Susceptibility to Pancreatic Cancer: ASCO Provisional Clinical Opinion by Stoffel, Elena M, McKernin, Shannon E, Brand, Randall, Canto, Marcia, Goggins, Michael, Moravek, Cassadie, Nagarajan, Arun, Petersen, Gloria M, Simeone, Diane M, Yurgelun, Matthew, Khorana, Alok A

“…An ASCO provisional clinical opinion (PCO) offers timely clinical direction to ASCO's membership and other health care providers. This PCO addresses…”
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Pancreatic Cancer Stem Cells: Implications for the Treatment of Pancreatic Cancer by Simeone, Diane M

“…Pancreatic cancer is a highly lethal disease that is usually diagnosed at a late stage for which there are few effective therapies. Emerging evidence has…”
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The Notch pathway is important in maintaining the cancer stem cell population in pancreatic cancer by Abel, Ethan V, Kim, Edward J, Wu, Jingjiang, Hynes, Mark, Bednar, Filip, Proctor, Erica, Wang, Lidong, Dziubinski, Michele L, Simeone, Diane M

“…Pancreatic cancer stem cells (CSCs) represent a small subpopulation of pancreatic cancer cells that have the capacity to initiate and propagate tumor…”
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Metabolic Regulation of Redox Balance in Cancer by Purohit, Vinee, Simeone, Diane M, Lyssiotis, Costas A

“…Reactive oxygen species (ROS) are chemically active free radicals produced by partial reduction of oxygen that can activate discrete signaling pathways or…”
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Biology and Clinical Applications of Pancreatic Cancer Stem Cells by Abel, Ethan V, Simeone, Diane M

“…Pancreatic ductal adenocarcinomas comprise a hierarchy of tumor cells that develop around a population of cancer stem cells. The cancer stem cells promote…”
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Pancreatic Ductal Adenocarcinoma Radiology Reporting Template: Consensus Statement of the Society of Abdominal Radiology and the American Pancreatic Association by Al-Hawary, Mahmoud M., MD, Francis, Isaac R., MD, Chari, Suresh T., MD, Fishman, Elliot K., MD, Hough, David M., MD, Lu, David S., MD, Macari, Michael, MD, Megibow, Alec J., MD, Miller, Frank H., MD, Mortele, Koenraad J., MD, Merchant, Nipun B., MD, Minter, Rebecca M., MD, Tamm, Eric P., MD, Sahani, Dushyant V., MD, Simeone, Diane M., MD

“…Pancreatic ductal adenocarcinoma is an aggressive malignancy with a high mortality rate. Proper determination of the extent of disease on imaging studies at…”
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Pancreatic Cancer Stem Cells by LEE, Cheong J, DOSCH, Joseph, SIMEONE, Diane M

“…Cellular heterogeneity in cancer was observed decades ago by studies in mice which showed that distinct subpopulations of cells within a tumor mass are capable…”
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c-Met Is a Marker of Pancreatic Cancer Stem Cells and Therapeutic Target by Li, Chenwei, Wu, Jing–Jiang, Hynes, Mark, Dosch, Joseph, Sarkar, Bedabrata, Welling, Theodore H, Pasca di Magliano, Marina, Simeone, Diane M

“…Background & Aims Growth of many different tumor types requires a population of self-renewing cancer stem cells (CSCs). c-Met is a marker of normal mouse…”
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Identification of human pancreatic cancer stem cells by Li, Chenwei, Lee, C J, Simeone, Diane M

“…Emerging evidence suggests that malignant tumors are composed of a small subset of distinct cancer cells, termed "cancer stem cells" (typically less than 5% of…”
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Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment by Werba, Gregor, Weissinger, Daniel, Kawaler, Emily A., Zhao, Ende, Kalfakakou, Despoina, Dhara, Surajit, Wang, Lidong, Lim, Heather B., Oh, Grace, Jing, Xiaohong, Beri, Nina, Khanna, Lauren, Gonda, Tamas, Oberstein, Paul, Hajdu, Cristina, Loomis, Cynthia, Heguy, Adriana, Sherman, Mara H., Lund, Amanda W., Welling, Theodore H., Dolgalev, Igor, Tsirigos, Aristotelis, Simeone, Diane M.

“…The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a complex ecosystem that drives tumor progression; however, in-depth single cell…”
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Identification of pancreatic cancer stem cells by CHENWEI LI, HEIDT, David G, DALERBA, Piero, BURANT, Charles F, LANJING ZHANG, ADSAY, Volkan, WICHA, Max, CLARKE, Michael F, SIMEONE, Diane M

“…Emerging evidence has suggested that the capability of a tumor to grow and propagate is dependent on a small subset of cells within a tumor, termed cancer stem…”
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Bmi1 enhances tumorigenicity and cancer stem cell function in pancreatic adenocarcinoma by Proctor, Erica, Waghray, Meghna, Lee, Cheong Jun, Heidt, David G, Yalamanchili, Malica, Li, Chenwei, Bednar, Filip, Simeone, Diane M

“…Bmi1 is an integral component of the Polycomb Repressive Complex 1 (PRC1) and is involved in the pathogenesis of multiple cancers. It also plays a key role in…”
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Pancreatic ductal adenocarcinoma radiology reporting template: consensus statement of the Society of Abdominal Radiology and the American Pancreatic Association by Al-Hawary, Mahmoud M, Francis, Isaac R, Chari, Suresh T, Fishman, Elliot K, Hough, David M, Lu, David S, Macari, Michael, Megibow, Alec J, Miller, Frank H, Mortele, Koenraad J, Merchant, Nipun B, Minter, Rebecca M, Tamm, Eric P, Sahani, Dushyant V, Simeone, Diane M

“…Pancreatic ductal adenocarcinoma is an aggressive malignancy with a high mortality rate. Proper determination of the extent of disease on imaging studies at…”
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A Radial Flow Microfluidic Device for Ultra-High-Throughput Affinity-Based Isolation of Circulating Tumor Cells by Murlidhar, Vasudha, Zeinali, Mina, Grabauskiene, Svetlana, Ghannad-Rezaie, Mostafa, Wicha, Max S., Simeone, Diane M., Ramnath, Nithya, Reddy, Rishindra M., Nagrath, Sunitha

“…Circulating tumor cells (CTCs) are believed to play an important role in metastasis, a process responsible for the majority of cancer‐related deaths. But their…”
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Combining molecular and fossil data to infer demographic history of Quercus cerris: insights on European eastern glacial refugia by Bagnoli, F, Tsuda, Y, Fineschi, S, Bruschi, P, Magri, D, Zhelev, P, Paule, L, Simeone, M. C, González‐Martínez, S. C, Vendramin, G. G

“…AIM: Phylogeographical studies of Eastern Mediterranean species are rare. We aim to fill a gap in the current understanding of the role of Eastern…”
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