Search Results - "Simbruner, Georg"

Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT by Simbruner, Georg, Mittal, Rashmi A, Rohlmann, Friederike, Muche, Rainer

“…Mild hypothermia after perinatal hypoxic-ischemic encephalopathy (HIE) reduces neurologic sequelae without significant adverse effects, but studies are needed…”
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Erythropoietin is neuroprotective against NMDA-receptor-mediated excitotoxic brain injury in newborn mice by Keller, Matthias, Yang, Jingli, Griesmaier, Elke, Gorna, Agnieszka, Sarkozy, Gergely, Urbanek, Martina, Gressens, Pierre, Simbruner, Georg

“…Using an established mouse model of human periventricular leukomalacia, we investigated whether EPO could reduce excitotoxic damage. When administered 1 h…”
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Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice by Doverhag, Christina, Keller, Matthias, Karlsson, Anna, Hedtjarn, Maj, Nilsson, Ulf, Kapeller, Edith, Sarkozy, Gergely, Klimaschewski, Lars, Humpel, Christian, Hagberg, Henrik, Simbruner, Georg, Gressens, Pierre, Savman, Karin

“…Abstract Background Inflammation and reactive oxygen species (ROS) are important in the development of perinatal brain injury. The ROS-generating enzyme NADPH…”
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Effect of exogenous surfactants on viability and DNA synthesis in A549, immortalized mouse type II and isolated rat alveolar type II cells by Wemhöner, Andreas, Jennings, Paul, Haller, Thomas, Rüdiger, Mario, Simbruner, Georg

“…In mechanically ventilated preterm infants with respiratory distress syndrome (RDS), exogenous surfactant application has been demonstrated both to decrease…”
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Hypothermia: An Evolving Treatment for Neonatal Hypoxic Ischemic Encephalopathy by Gunn, Alistair J, Hoehn, Thomas, Hansmann, Georg, Buhrer, Christoph, Simbruner, Georg, Yager, Jerome, Levene, Malcolm, Hamrick, Shannon E. G, Shankaran, Seetha, Thoresen, Marianne

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Interleukin-1 receptor antagonist and interleukin-6 for early diagnosis of neonatal sepsis 2 days before clinical manifestation by Küster, Helmut, Weiss, Michael, Willeitner, Andreas E, Detlefsen, Stefanie, Jeremias, Irmela, Zbojan, Juraj, Geiger, Ralf, Lipowsky, Gert, Simbruner, Georg

“…Neonatal sepsis is a common and lifethreatening disorder, particularly among preterm infants. Early initiation of antibiotic therapy is frequently delayed…”
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Role of p75NTR in NMDAR-mediated excitotoxic brain injury in neonatal mice by Griesmaier, Elke, Schlager, Gerald, Wegleiter, Karina, Hermann, Martin, Urbanek, Martina, Simbruner, Georg, Keller, Matthias

“…Abstract Background: Perinatal brain injury in preterm infants is a major cause of neurological handicap. The role of the neurotrophin receptor p75 (p75NTR )…”
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Lung growth induced by prenatal instillation of perfluorocarbon into the fetal rabbit lung by Muensterer, Oliver J, Till, Holger, Bergmann, Florian, Klis, Verena J, Metzger, Roman, Deprest, Jan A, Simbruner, Georg

“…The study's aim was to evaluate whether prenatal instillation of perfluorooctylbromide (PFOB, a perfluorocarbon) into the lungs of fetal rabbits leads to…”
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Therapeutic hypothermia in neonates. Review of current clinical data, ILCOR recommendations and suggestions for implementation in neonatal intensive care units by Hoehn, Thomas, Hansmann, Georg, Bührer, Christoph, Simbruner, Georg, Gunn, Alistair J, Yager, Jerome, Levene, Malcolm, Hamrick, Shannon E.G, Shankaran, Seetha, Thoresen, Marianne

“…Summary Recent evidence suggests that the current ILCOR guidelines regarding hypothermia for the treatment of neonatal encephalopathy need urgent revision. In…”
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Dextromethorphan is protective against sensitized N-methyl-d-aspartate receptor-mediated excitotoxic brain damage in the developing mouse brain by Keller, Matthias, Griesmaier, Elke, Auer, Maria, Schlager, Gerald, Urbanek, Martina, Simbruner, Georg, Gressens, Pierre, Sárközy, Gergely

“…Enhanced glutamate release and inflammation play an important role in the pathogenesis of developmental brain injury. Although N‐methyl‐d‐aspartate receptor…”
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Role of p75 super(NTR) in NMDAR-mediated excitotoxic brain injury in neonatal mice by Griesmaier, Elke, Schlager, Gerald, Wegleiter, Karina, Hermann, Martin, Urbanek, Martina, Simbruner, Georg, Keller, Matthias

“…Background: Perinatal brain injury in preterm infants is a major cause of neurological handicap. The role of the neurotrophin receptor p75 (p75 super(NTR)) in…”
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Policy benchmarking report on neonatal health and social policies in 13 European countries by Keller, Matthias, Felderhoff-Mueser, Ursula, Lagercrantz, Hugo, Dammann, Olaf, Marlow, Neil, Hüppi, Petra, Buonocore, Giuseppe, Poets, Christian, Simbruner, Georg, Guimaraes, Hercilia, Mader, Silke, Merialdi, Mario, Saugstad, Ola D

“…Background and aim:  Preterm birth is the major cause of infant mortality and morbidity in both developed and developing countries. In Europe, the prevalence…”
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Role of p75 NTR in NMDAR-mediated excitotoxic brain injury in neonatal mice by Griesmaier, Elke, Schlager, Gerald, Wegleiter, Karina, Hermann, Martin, Urbanek, Martina, Simbruner, Georg, Keller, Matthias

“…Background: Perinatal brain injury in preterm infants is a major cause of neurological handicap. The role of the neurotrophin receptor p75 (p75 NTR) in the…”
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Standard EEG as predictor of neurodevelopmental outcome by Lukavac Tesin Marija, Timischl, Maria, Korac, Jasmina, Macut, Tatjana, Prekajski, Niveska, Simbruner, Georg

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Importance of clinical examination to predict neurological outcome by Lukavac⁎, Tesin Marija, Pejcic, Iris, Minic, Aleksandra, Rascanin, Mirjana, Simbruner, Georg

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Systemic application of granulocyte-colony stimulating factor and stem cell factor exacerbates excitotoxic brain injury in newborn mice by KELLER, Matthias, SIMBRUNER, Georg, GORNA, Agnieszka, URBANEK, Martina, TINHOFER, Inge, GRIESMAIER, Elke, SARKOZY, Gergely, SCHWENDIMANN, Leslie, GRESSENS, Pierre

“…Granulocyte-colony stimulating factor (G-CSF) has been shown to reduce brain lesion size and mortality in adult mice after hypoxic-ischemic injury. Another…”
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T3 replacement does not prevent excitotoxic cell death but reduces developmental neuronal apoptosis in newborn mice by Sárközy, Gergely, Griesmaier, Elke, He, Xiangying, Kapelari, Klaus, Urbanek, Martina, Simbruner, Georg, Gressens, Pierre, Keller, Matthias

“…Abstract Background Periventricular leukomalacia (PVL) is a major cause of neurological handicap in pre-term infants. At present, there are no effective or…”
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Therapeutic hypothermia in neonates — Review of current clinical data, ILCOR recommendations and suggestions for implementation in neonatal intensive care units by Hoehn⁎, Thomas, Hansmann, Georg, Bührer, Christoph, Simbruner, Georg, Gunn, Alistair, Yager, Jerome, Levene, Malcolm, Hamrick, Shannon, Shankaran, Seetha, Thoresen, Marianne

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Premature infants are less capable of maintaining thermal balance of head and body with increases of thermal environment than with decreases by Simbruner, Georg, Ruttner, Eva-Maria, Schulze, Andreas, Perzlmaier, Katharina

“…We investigated whether premature infants nursed at the upper range of normal body temperature are more capable of maintaining their nasopharyngeal and rectal…”
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Intrapulmonary perfluorooctyl bromide instillation in fetal rabbits by Muensterer, Oliver J., Klis, Verena J., Till, Holger, Bergmann, Florian, Metzger, Roman, Simbruner, Georg

“…Instilling perfluorooctyl bromide (PFOB) into the fetal lung may lead to alveolar distension. The aim of the study was to evaluate the safety of PFOB…”
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