Search Results - "Simard, John J.L."

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin- 2 Receptor β by Suzuki, Haruhiko, Kündig, Thomas M., Furlonger, Caren, Wakeham, Andrew, Timms, Emma, Matsuyama, Toshifumi, Schmits, Rudolf, John J. L. Simard, Ohashi, Pamela S., Griesser, Henrik, Taniguchi, Tadatsugu, Paige, Christopher J., Mak, Tak W.

“…In mice lacking the interleukin-2 receptor β chain (IL-2Rβ), T cells were shown to be spontaneously activated, resulting in exhaustive differentiation of B…”
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CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity by SCHMITS, R, FILMUS, J, FURLONGER, C, ZAKARIAN, A, SIMARD, J. J. L, OHASHI, P. S, PAIGE, C. J, GUTIERREZ-RAMOS, J. C, MAK, T. W, GERWIN, N, SENALDI, G, KIEFER, F, KUNDIG, T, WAKEHAM, A, SHAHINIAN, A, CATZAVELOS, C, RAK, J

“…CD44 is expressed in various isoforms on numerous cell types and tissues during embryogenesis and in the mature organism. CD44 may also be involved in tumor…”
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CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity by Schmits, Rudolf, Filmus, Jorge, Gerwin, Nicole, Senaldi, Giorgio, Kiefer, Friedemann, Kundig, Thomas, Wakeham, Andrew, Shahinian, Arda, Catzavelos, Charles, Rak, Janusz, Furlonger, Caren, Zakarian, Arsen, Simard, John J.L., Ohashi, Pamela S., Paige, Christopher J., Gutierrez-Ramos, Jose C., Mak, Tak W.

“…CD44 is expressed in various isoforms on numerous cell types and tissues during embryogenesis and in the mature organism. CD44 may also be involved in tumor…”
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Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice by Amakawa, Ryuichi, Hakem, Anne, Kundig, Thomas M, Matsuyama, Toshifumi, Simard, John J.L, Timms, Emma, Wakeham, Andrew, Mittruecker, Hans-Willi, Griesser, Henrik, Takimoto, Hiroaki, Schmits, Rudolf, Shahinian, Arda, Ohashi, Pamela S, Penninger, Josef M, Mak, Tak W

“…CD30 is found on Reed–Sternberg cells of Hodgkin's disease and on a variety of non-Hodgkin's lymphoma cells and is up-regulated on cells after Epstein–Barr…”
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Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs by Kündig, Thomas M., Bachmann, Martin F., DiPaolo, Claudio, John J. L. Simard, Battegay, Manuel, Lother, Heinz, Gessner, André, Kühlcke, Klaus, Ohashi, Pamela S., Hengartner, Hans, Zinkernagel, Rolf M.

“…Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However,…”
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LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor by Schmits, R, Kündig, T M, Baker, D M, Shumaker, G, Simard, J J, Duncan, G, Wakeham, A, Shahinian, A, van der Heiden, A, Bachmann, M F, Ohashi, P S, Mak, T W, Hickstein, D D

“…The leukocyte integrin LFA-1 (CD11a/CD18) plays an important role in lymphocyte recirculation and homotypic interactions. Leukocytes from mice lacking CD11a…”
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On the Role of Antigen in Maintaining Cytotoxic T-Cell Memory by Kündig, Thomas M., Bachmann, Martin F., Oehen, Stephan, Hoffmann, Urs W., John J. L. Simard, Kalberer, Christian P., Pircher, Hanspeter, Ohashi, Pamela S., Hengartner, Hans, Zinkernagel, Rolf M.

“…This study evaluated whether T-cell memory reflects increased precursor frequencies of specific long-lived T cells and/or a low-level immune response against…”
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