Search Results - "Simao, Fabricio"

Enhanced susceptibility to seizures modulated by high interleukin-1[beta] levels during early life malnutrition by Simao, Fabrício, Habekost Oliveira, Victória, Lahourgue Nunes, Magda

“…Early malnutrition in life has permanent consequences on brain development and has been suggested to influence seizure susceptibility. Despite malnutrition is…”
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Regeneration of glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy by Fu, Jialin, Shinjo, Takanori, Li, Qian, St-Louis, Ronald, Park, Kyoungmin, Yu, Marc G, Yokomizo, Hisashi, Simao, Fabricio, Huang, Qian, Wu, I-Hsien, King, George L

“…Diabetic nephropathy (DN) arises from systemic and local changes in glucose metabolism and hemodynamics. We have reported that many glycolytic and…”
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Editorial: Neurorepair Strategies to Induce Angiogenesis, Neurogenesis and Synaptic Plasticity by Klempin, Friederike, Simão, Fabricio, Cunha Xavier Pinto, Mauro

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Pro-Angiogenic Effects of Resveratrol in Brain Endothelial Cells: Nitric Oxide-Mediated Regulation of Vascular Endothelial Growth Factor and Metalloproteinases by Simão, Fabricio, Pagnussat, Aline S, Seo, Ji Hae, Navaratna, Deepti, Leung, Wendy, Lok, Josephine, Guo, Shuzhen, Waeber, Christian, Salbego, Christianne G, Lo, Eng H

“…Resveratrol may be a powerful way of protecting the brain against a wide variety of stress and injury. Recently, it has been proposed that resveratrol not only…”
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Abstract P760: Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats by Simao, Fabricio, Guan, Jian, Clermont, Allen, Pham, Loc-Duyen, Ustunkaya, Tuna, Feener, Edward P

“…IntroductionHypertension is a leading risk factor for spontaneous intracerebral hemorrhage. Plasma Kallikrein (PKa) has been implicated in contributing to…”
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Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke by Simão, Fabrício, Ustunkaya, Tuna, Clermont, Allen C., Feener, Edward P.

“…Thrombolytic therapy using tissue plasminogen activator (tPA) in acute stroke is associated with increased risks of cerebral hemorrhagic transformation and…”
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Resveratrol prevents CA1 neurons against ischemic injury by parallel modulation of both GSK-3β and CREB through PI3-K/Akt pathways by Simão, Fabrício, Matté, Aline, Pagnussat, Aline S., Netto, Carlos A., Salbego, Christianne G.

“…Accumulating evidence indicates that resveratrol potently protects against cerebral ischemia damage due to its oxygen free radicals scavenging and antioxidant…”
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The Role of Astrocytes in the Neurorepair Process by Chiareli, Raphaela Almeida, Carvalho, Gustavo Almeida, Marques, Bruno Lemes, Mota, Lennia Soares, Oliveira-Lima, Onésia Cristina, Gomes, Rodrigo Mello, Birbrair, Alexander, Gomez, Renato Santiago, Simão, Fabrício, Klempin, Friederike, Leist, Marcel, Pinto, Mauro Cunha Xavier

“…Astrocytes are highly specialized glial cells responsible for trophic and metabolic support of neurons. They are associated to ionic homeostasis, the…”
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Exendin-4 Reverses Biochemical and Functional Alterations in the Blood–Brain and Blood–CSF Barriers in Diabetic Rats by Zanotto, Caroline, Simão, Fabrício, Gasparin, Manuela Sangalli, Biasibetti, Regina, Tortorelli, Lucas Silva, Nardin, Patrícia, Gonçalves, Carlos-Alberto

“…Diabetes mellitus (DM) is a metabolic disorder associated with micro- and macrovascular alterations that contribute to the cognitive impairment observed in…”
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The Effects of the Contact Activation System on Hemorrhage by Simão, Fabrício, Feener, Edward P

“…The contact activation system (CAS) exerts effects on coagulation multiple mechanisms, which modulate both the intrinsic and extrinsic coagulation cascades as…”
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Resveratrol preconditioning modulates inflammatory response in the rat hippocampus following global cerebral ischemia by Simão, Fabrício, Matté, Aline, Pagnussat, Aline S., Netto, Carlos Alexandre, Salbego, Christianne G.

“…► Resveratrol pretreatment decreased the expression of NF-κB and JNK levels. ► Resveratrol also ameliorated the elevated levels of substrate iNOS and COX-2. ►…”
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Enhanced susceptibility to seizures modulated by high interleukin‐1β levels during early life malnutrition by Simão, Fabrício, Habekost Oliveira, Victória, Nunes, Magda Lahourgue

“…ABSTRACT Early malnutrition in life has permanent consequences on brain development and has been suggested to influence seizure susceptibility. Despite…”
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Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats by Guan, Jian, Clermont, Allen C., Pham, Loc-Duyen, Ustunkaya, Tuna, Revenko, Alexey S., MacLeod, A. Robert, Feener, Edward P., Simão, Fabrício

“…Plasma kallikrein (PKa) has been implicated in contributing to hemorrhage following thrombolytic therapy; however, its role in spontaneous intracerebral…”
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Transplantation of Bone Marrow Mononuclear Cells Modulates Hippocampal Expression of Growth Factors in Chronically Epileptic Animals by Zanirati, Gabriele, Azevedo, Pamella Nunes, Marinowic, Daniel Rodrigo, Rodrigues, Felipe, Oliveira Dias, Ana Christina, Venturin, Gianina Teribele, Greggio, Samuel, Simão, Fabrício, DaCosta, Jaderson Costa

“…Summary Aims In previous studies, transplantation of bone marrow mononuclear cells (BMMCs) in epileptic animals has been found to be neuroprotective. However,…”
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Resveratrol prevents oxidative stress and inhibition of Na super(+K) super(+)-ATPase activity induced by transient global cerebral ischemia in rats by Simao, Fabricio, Matte, Aline, Matte, Cristiane, Soares, Flavia MS, Wyse, Angela TS, Netto, Carlos Alexandre, Salbego, Christianne G

“…Increased oxidative stress and energy metabolism deficit have been regarded as an important underlying cause for neuronal damage induced by cerebral…”
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Hypoxic and Reoxygenated Microenvironment: Stemness and Differentiation State in Glioblastoma by Gaelzer, Mariana Maier, Santos, Mariana Silva dos, Coelho, Bárbara Paranhos, de Quadros, Alice Hoffman, Simão, Fabrício, Usach, Vanina, Guma, Fátima Costa Rodrigues, Setton-Avruj, Patrícia, Lenz, Guido, Salbego, Christianne G.

“…Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults. Hypoxia is a distinct feature in GBM and plays a significant role…”
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Protective effect of resveratrol against oxygen–glucose deprivation in organotypic hippocampal slice cultures: Involvement of PI3-K pathway by Zamin, Lauren L., Dillenburg-Pilla, Patrícia, Argenta-Comiran, Ricardo, Horn, Ana Paula, Simão, Fabrício, Nassif, Melissa, Gerhardt, Daniéli, Frozza, Rudimar L., Salbego, Christianne

“…Here we investigated the neuroprotective effect of resveratrol in an in vitro model of ischemia. We used organotypic hippocampal cultures exposed to…”
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Effects of undernourishment, recurrent seizures and enriched environment during early life in hippocampal morphology by Alvarez, Paula Steffen, Simão, Fabrício, Hemb, Marta, Xavier, Léder Leal, Nunes, Magda Lahorgue

“…•Undernourishment decreased neuronal density in CA1 and CA3 subfield of hippocampus.•Seizures decreased neuronal density in CA1 subfield of…”
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Dietary omega-3 fatty acids attenuate cellular damage after a hippocampal ischemic insult in adult rats by Moreira, Júlia D., Knorr, Luisa, Thomazi, Ana Paula, Simão, Fabrício, Battú, Cíntia, Oses, Jean Pierre, Gottfried, Carmem, Wofchuk, Susana, Salbego, Christianne, Souza, Diogo O., Perry, Marcos L.S., Vinadé, Lúcia

“…The role of omega-3 polyunsaturated fatty acids (3PUFAs) on brain function is increasingly demonstrated. Here, the effect of dietary deprivation of essential…”
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Na super(+), K super(+) ATPase Activity Is Reduced in Amygdala of Rats with Chronic Stress-Induced Anxiety-Like Behavior by Crema, Leonardo, Schlabitz, Michele, Tagliari, Barbara, Cunha, Aline, Simao, Fabricio, Krolow, Rachel, Pettenuzzo, Leticia, Salbego, Christianne, Vendite, Deusa, Wyse, Angela TS, Dalmaz, Carla

“…In this study, we examined the effects of two chronic stress regimens upon anxiety-like behavior, Na super(+), K super(+)-ATPase activity and immunocontent,…”
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