Search Results - "Simanek, Eric E."

Two Decades of Triazine Dendrimers by Simanek, Eric E.

“…For two decades, methods for the synthesis and characterization of dendrimers based on [1,3,5]-triazine have been advanced by the group. Motivated by the…”
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Cancer Therapies Utilizing the Camptothecins: A Review of the in Vivo Literature by Venditto, Vincent J, Simanek, Eric E

“…This review summarizes the in vivo assessmentpreliminary, preclinical, and clinicalof chemotherapeutics derived from camptothecin or a derivative…”
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Click Chemistry of Melamine Dendrimers: Comparison of "Click-and-Grow" and "Grow-Then-Click" Strategies Using a Divergent Route to Diversity by Numai, Sanami, Yoto, Risako, Kimura, Masataka, Simanek, Eric E, Kitano, Yoshikazu

“…Dendrimers are attractive macromolecules for a broad range of applications owing to their well-defined shapes and dimensions, highly branched and globular…”
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Computational and Experimental Evidence for Templated Macrocyclization: The Role of a Hydrogen Bond Network in the Quantitative Dimerization of 24-Atom Macrocycles by Menke, Alexander J, Henderson, Nicholas C, Kouretas, Lola C, Estenson, Anne N, Janesko, Benjamin G, Simanek, Eric E

“…In the absence of preorganization, macrocyclization reactions are often plagued by oligomeric and polymeric side products. Here, a network of hydrogen bonds…”
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Synthesis of Water-Soluble Dendrimers Based on Melamine Bearing 16 Paclitaxel Groups by Lim, Jongdoo, Simanek, Eric E

“…The design, synthesis, and characterization of triazine dendrimers derivatized with the anticancer agent paclitaxel are described. The precursor generation two…”
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Experimental and Computational Evidence for an Inversion in Guest Capacity in High-Generation Triazine Dendrimer Hosts by Lim, Jongdoo, Pavan, Giovanni M, Annunziata, Onofrio, Simanek, Eric E

“…The synthesis, characterization, and host–guest chemistry of high-generation triazine dendrimers are described. With pyrene and camptothecin as guests,…”
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Nanoparticle Effects on Human Platelets in Vitro: A Comparison between PAMAM and Triazine Dendrimers by Enciso, Alan E, Neun, Barry, Rodriguez, Jamie, Ranjan, Amalendu P, Dobrovolskaia, Marina A, Simanek, Eric E

“…Triazine and PAMAM dendrimers of similar size and number of cationic surface groups were compared for their ability to promote platelet aggregation. Triazine…”
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Cytotoxicity, Hemolysis, and Acute in Vivo Toxicity of Dendrimers Based on Melamine, Candidate Vehicles for Drug Delivery by Chen, Hui-Ting, Neerman, Michael F, Parrish, Alan R, Simanek, Eric E

“…A small library of dendrimers was prepared from a common precursor that is available in 5 g scale in five linear steps at 56% overall yield. The precursor is a…”
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Functionalization of a Triazine Dendrimer Presenting Four Maleimides on the Periphery and a DOTA Group at the Core by Lee, Changsuk, Ji, Kun, Simanek, Eric E

“…A readily and rapidly accessible triazine dendrimer was manipulated in four steps with 23% overall yield to give a construct displaying four maleimide groups…”
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Antitumor Activity and Molecular Dynamics Simulations of Paclitaxel-Laden Triazine Dendrimers by Lim, Jongdoo, Lo, Su-Tang, Hill, Sonia, Pavan, Giovanni M, Sun, Xiankai, Simanek, Eric E

“…The antitumor activities of triazine dendrimers bearing paclitaxel, a well-known mitotic inhibitor, are evaluated in SCID mice bearing human prostate cancer…”
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Triazine Dendrimers as Nonviral Vectors for in Vitro and in Vivo RNAi: The Effects of Peripheral Groups and Core Structure on Biological Activity by Merkel, Olivia M, Mintzer, Meredith A, Librizzi, Damiano, Samsonova, Olga, Dicke, Tanja, Sproat, Brian, Garn, Holger, Barth, Peter J, Simanek, Eric E, Kissel, Thomas

“…A family of triazine dendrimers, differing in their core flexibility, generation number, and surface functionality, was prepared and evaluated for its ability…”
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The 8 year thicket of triazine dendrimers: strategies, targets and applications by Simanek, Eric E., Abdou, Hanan, Lalwani, Sanjiv, Lim, Jongdoo, Mintzer, Meredith, Venditto, Vincent J., Vittur, Brandon

“… The diversity communicated by these groups yields dendrimers ranging from those with a common surface to examples where two groups were presented to those…”
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Tumor Uptake of Triazine Dendrimers Decorated with Four, Sixteen, and Sixty-Four PSMA-Targeted Ligands: Passive versus Active Tumor Targeting by Lim, Jongdoo, Guan, Bing, Nham, Kien, Hao, Guiyang, Sun, Xiankai, Simanek, Eric E

“…Various glutamate urea ligands have displayed high affinities to prostate specific membrane antigen (PSMA), which is highly overexpressed in prostate and other…”
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Conformational Analysis of Triazine Dendrimers: Using NMR Spectroscopy To Probe the Choreography of a Dendrimer’s Dance by Moreno, Karlos X, Simanek, Eric E

“…One-dimensional (1D) and two-dimensional (2D) NMR studies are used to probe the conformation of a melamine dendrimer bearing unique NMR signals from the core…”
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Conjugation to the cell-penetrating peptide TAT potentiates the photodynamic effect of carboxytetramethylrhodamine by Srinivasan, Divyamani, Muthukrishnan, Nandhini, Johnson, Gregory A, Erazo-Oliveras, Alfredo, Lim, Jongdoo, Simanek, Eric E, Pellois, Jean-Philippe

“…Cell-penetrating peptides (CPPs) can transport macromolecular cargos into live cells. However, the cellular delivery efficiency of these reagents is often…”
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Nonviral Vectors for Gene Delivery by Mintzer, Meredith A, Simanek, Eric E

“…Nonviral sectors for gene delivery are examined. The use of lipid-based vectors and polymeric vectors are the focus of the research…”
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Triazine dendrimers as drug delivery systems: From synthesis to therapy by Lim, Jongdoo, Simanek, Eric E.

“…The use of triazine dendrimers as drug delivery systems benefits from their synthetic versatility and well-defined structure. Triazine dendrimers can be…”
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Biological Assessment of Triazine Dendrimer: Toxicological Profiles, Solution Behavior, Biodistribution, Drug Release and Efficacy in a PEGylated, Paclitaxel Construct by Lo, Su-Tang, Stern, Stephan, Clogston, Jeffrey D, Zheng, Jiwen, Adiseshaiah, Pavan P, Dobrovolskaia, Marina, Lim, Jongdoo, Patri, Anil K, Sun, Xiankai, Simanek, Eric E

“…The physicochemical characteristics, in vitro properties, and in vivo toxicity and efficacy of a third generation triazine dendrimer bearing approximately nine…”
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Thermoregulated Coacervation, Metal-Encapsulation and Nanoparticle Synthesis in Novel Triazine Dendrimers by Ramírez-Crescencio, Fermín, Enciso, Alan E, Hasan, Mirza, da Costa, Viviana C P, Annunziata, Onofrio, Redón, Rocío, Coffer, Jeffery L, Simanek, Eric E

“…The synthesis and solubility behaviors of four generation five (G5) triazine dendrimers are studied. While the underivatized cationic dendrimer is soluble in…”
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Impact of Solvent and Protonation State on Rotational Barriers in [s]-Triazines by Claton, Liam E., Pan, Hongjun, Simanek, Eric E.

“…Amine-substituted [s]-triazines display hindered rotation around the triazine-N bond. While this barrier, ΔG ‡, has been measured to be between 15.1 and 17.7…”
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