Search Results - "Siman, Robert"

The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy by Siman, Robert, Cocca, Ryan, Dong, Yina

“…The perforant pathway projection from layer II of the entorhinal cortex to the hippocampal dentate gyrus is especially important for long-term memory…”
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Serum SNTF, a Surrogate Marker of Axonal Injury, Is Prognostic for Lasting Brain Dysfunction in Mild TBI Treated in the Emergency Department by Siman, Robert, Cui, Hongmei, Wewerka, Sandi S, Hamel, Lydia, Smith, Douglas H, Zwank, Michael D

“…Mild traumatic brain injury (mTBI) causes persisting post-concussion syndrome for many patients without abnormalities on conventional neuroimaging. Currently,…”
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Cross-talk between Calpain and Caspase Proteolytic Systems During Neuronal Apoptosis by Neumar, Robert W., Xu, Y. Anne, Gada, Hemal, Guttmann, Rodney P., Siman, Robert

“…Cross-talk between calpain and caspase proteolytic systems has complicated efforts to determine their distinct roles in apoptotic cell death. This study…”
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Evidence that a panel of neurodegeneration biomarkers predicts vasospasm, infarction, and outcome in aneurysmal subarachnoid hemorrhage by Siman, Robert, Giovannone, Nicholas, Toraskar, Nikhil, Frangos, Suzanne, Stein, Sherman C, Levine, Joshua M, Kumar, Monisha A

“…Biomarkers for neurodegeneration could be early prognostic measures of brain damage and dysfunction in aneurysmal subarachnoid hemorrhage (aSAH) with clinical…”
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Proteins released from degenerating neurons are surrogate markers for acute brain damage by Siman, Robert, McIntosh, Tracy K, Soltesz, Kristie M, Chen, Zhaoming, Neumar, Robert W, Roberts, Victoria L

“…The experimental and clinical study of degenerative brain disorders would benefit from new surrogate markers for brain damage. To identify novel candidate…”
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Reframing the Biological Basis of Neuroprotection Using Functional Genomics: Differentially Weighted, Time-Dependent Multifactor Pathogenesis of Human Ischemic Brain Damage by Kofke, William A, Ren, Yue, Augoustides, John G, Li, Hongzhe, Nathanson, Katherine, Siman, Robert, Meng, Qing Cheng, Bu, Weiming, Yandrawatthana, Sukanya, Kositratna, Guy, Kim, Cecilia, Bavaria, Joseph E

“…Neuroprotection studies are generally unable to demonstrate efficacy in humans. Our specific hypothesis is that multiple pathophysiologic pathways, of variable…”
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Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition by DeRidder, Michael N., Simon, Melissa J., Siman, Robert, Auberson, Yves P., Raghupathi, Ramesh, Meaney, David F.

“…Apoptotic or necrotic cell death in the hippocampus is a major factor underlying the cognitive impairments following traumatic brain injury. In this study, we…”
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Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury by Han, Byung Hee, Xu, Daigen, Choi, Junjeong, Han, Yongxin, Xanthoudakis, Steven, Roy, Sophie, Tam, John, Vaillancourt, John, Colucci, John, Siman, Robert, Giroux, Andre, Robertson, George S., Zamboni, Robert, Nicholson, Donald W., Holtzman, David M.

“…Hypoxia-ischemia (H-I) in the developing brain results in brain injury with prominent features of both apoptosis and necrosis. A peptide-based pan-caspase…”
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A Rapid Gene Delivery-Based Mouse Model for Early-Stage Alzheimer Disease-Type Tauopathy by Siman, Robert, Lin, Yin-Guo, Malthankar-Phatak, Gauri, Dong, Yina

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Calpain Activity in the Rat Brain after Transient Forebrain Ischemia by Neumar, Robert W., Meng, Frank H., Mills, Angela M., Xu, Y.Anne, Zhang, Chen, Welsh, Frank A., Siman, Robert

“…Activity of the Ca2+-dependent protease calpain is increased in neurons after global and focal brain ischemia, and may contribute to postischemic injury…”
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Comparison of Calpain and Caspase Activities in the Adult Rat Brain after Transient Forebrain Ischemia by Zhang, Chen, Siman, Robert, Xu, Y.Anne, Mills, Angela M., Frederick, James R., Neumar, Robert W.

“…The role of calpain and caspase family proteases in postischemic neuronal death remains controversial. This study compared the timing, location, and relative…”
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Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo by Siman, R, Noszek, J C

“…Neuronal activity regulates the catabolism of specific structural proteins in adult mammalian brain. Pharmacological stimulation of rat hippocampal neurons by…”
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Activation of calpain‐1 in myelin and microglia in the white matter of the aged rhesus monkey by Hinman, Jason D., Duce, James A., Siman, Robert A., Hollander, William, Abraham, Carmela R.

“…Ultrastructural disruption of myelin sheaths and a loss of myelin with age are well‐documented phenomena in both the human and rhesus monkey. Age‐dependent…”
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E2F1 induces cell death, calpain activation, and MDMX degradation in a transcription independent manner implicating a novel role for E2F1 in neuronal loss in SIV encephalitis by Strachan, Gordon D., Koike, Maya A., Siman, Robert, Hall, David J., Jordan-Sciutto, Kelly L.

“…The E2F1 transcription factor can initiate proliferation or apoptosis, the latter by both transcription‐dependent and ‐independent mechanisms. Recently, an…”
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Distinct Nuclear and Cytoplasmic Localization of Caspase Cleavage Products in Two Models of Induced Apoptotic Death in Dopamine Neurons of the Substantia Nigra by Oo, Tinmarla F., Siman, Robert, Burke, Robert E.

“…An emerging theme in programmed cell death (PCD) of neurons is that the mechanisms involved depend on the cellular context and the death-inducing stimulus. One…”
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Serum SNTF Increases in Concussed Professional Ice Hockey Players and Relates to the Severity of Postconcussion Symptoms by Siman, Robert, Shahim, Pashtun, Tegner, Yelverton, Blennow, Kaj, Zetterberg, Henrik, Smith, Douglas H

“…Biomarkers for diffuse axonal injury could have utilities for the acute diagnosis and clinical care of concussion, including those related to sports. The…”
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Glutamate receptor antagonists inhibit calpain-mediated cytoskeletal proteolysis in focal cerebral ischemia by Minger, Stephen L, Geddes, James W, Holtz, Mary L, Craddock, Susan D, Whiteheart, Sidney W, Siman, Robert G, Pettigrew, L.Creed

“…Excitatory amino acids may promote microtubular proteolysis observed in ischemic neuronal degeneration by calcium-mediated activation of calpain, a neutral…”
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Regional distribution and time-course of calpain activation following kainate-induced seizure activity in adult rat brain by Bi, Xiaoning, Chang, Vanessa, Siman, Robert, Tocco, Georges, Baudry, Michel

“…Systemic injection of kainic acid (KA) in adult rat elicits a pattern of neuronal pathology which exhibits several features of human temporal lobe epilepsy…”
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Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease by Zhang, Chen, McNeil, Elizabeth, Dressler, Lindsay, Siman, Robert

“…Neurogenesis in the adult hippocampus has been implicated in regulating long-term memory and mood, but its integrity in Alzheimer's disease (AD) is uncertain…”
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Endoplasmic Reticulum Stress-induced Cysteine Protease Activation in Cortical Neurons by Siman, Robert, Flood, Dorothy G., Thinakaran, Gopal, Neumar, Robert W.

“…Endoplasmic reticulum (ER) stress elicits protective responses of chaperone induction and translational suppression and, when unimpeded, leads to…”
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