Search Results - "Simabuco, Fernando"

The S6K protein family in health and disease by Tavares, Mariana R., Pavan, Isadora C.B., Amaral, Camila L., Meneguello, Letícia, Luchessi, Augusto D., Simabuco, Fernando M.

“…The S6K proteins are mTOR pathway effectors and accumulative evidence suggest that mTOR/S6K signaling contributes to several pathological conditions, such as…”
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p53 and metabolism: from mechanism to therapeutics by Simabuco, Fernando M, Morale, Mirian G, Pavan, Isadora C B, Morelli, Ana P, Silva, Fernando R, Tamura, Rodrigo E

“…The tumor cell changes itself and its microenvironment to adapt to different situations, including action of drugs and other agents targeting tumor control…”
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Checking NEKs: Overcoming a Bottleneck in Human Diseases by Peres de Oliveira, Andressa, Kazuo Issayama, Luidy, Betim Pavan, Isadora Carolina, Riback Silva, Fernando, Diniz Melo-Hanchuk, Talita, Moreira Simabuco, Fernando, Kobarg, Jörg

“…In previous years, several kinases, such as phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and extracellular-signal-regulated kinase…”
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Bioaccessibility of cashew nut kernel flour compounds released after simulated in vitro human gastrointestinal digestion by Sisconeto Bisinotto, Mariana, da Silva, Daniele Cristina, de Carvalho Fino, Luciana, Moreira Simabuco, Fernando, Neves Bezerra, Rosângela Maria, Costa Antunes, Adriane Elisabete, Bertoldo Pacheco, Maria Teresa

“…[Display omitted] •Simulated digestion enhances antioxidant activity of cashew nut flour compounds.•Digested soluble fraction of the cashew nut flour showed…”
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Aerobic Exercise Training Induces the Mitonuclear Imbalance and UPRmt in the Skeletal Muscle of Aged Mice by Cordeiro, André V, Brícola, Rafael S, Braga, Renata R, Lenhare, Luciene, Silva, Vagner R R, Anaruma, Chadi P, Katashima, Carlos K, Crisol, Barbara M, Simabuco, Fernando M, Silva, Adelino S R, Cintra, Dennys E, Moura, Leandro P, Pauli, José R, Ropelle, Eduardo R

“…Abstract The impairment of the mitochondrial functions is a hallmark of aging. During aging, there is a downregulation of two mechanisms strictly associated…”
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Regular swimming exercise prevented the acute and persistent mechanical muscle hyperalgesia by modulation of macrophages phenotypes and inflammatory cytokines via PPARγ receptors by de Azambuja, Graciana, Jorge, Carolina O., Gomes, Beatriz B., Lourenço, Hayla R., Simabuco, Fernando M., Oliveira-Fusaro, Maria Claudia G.

“…•Regular swimming exercise controls persistent muscle hyperalgesia by involvement of PPARγ.•Macrophages and inflammatory cytokines are involved in persistent…”
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Exercise alters the circadian rhythm of REV-ERB-α and downregulates autophagy-related genes in peripheral and central tissues by da Rocha, Alisson L., Pinto, Ana P., Bedo, Bruno L. S., Morais, Gustavo P., Oliveira, Luciana C., Carolino, Ruither O. G., Pauli, Jose R., Simabuco, Fernando M., de Moura, Leandro P., Ropelle, Eduardo R., Cintra, Dennys E., Rivas, Donato A., da Silva, Adelino S. R.

“…The transcriptional repressor REV-ERB-α, encoded by Nuclear Receptor Subfamily 1 Group D Member 1 ( Nr1d1 ), has been considered to play an essential role in…”
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PHYSICAL EXERCISE ACTIVATES PPAR GAMMA RECEPTORS AND DECREASES P-P38 MAPK RELATED TO P2X4 RECEPTORS ACTIVITY IN A MODEL OF ACUTE AND CHRONIC INFLAMMATORY MUSCLE HYPERALGESIA by Oliveira, Maria Claudia, Azambuja, Graciana, Simabuco, Fernando

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Acute exercise modulates Trim63 and Bmal1 in the skeletal muscle of IL-10 knockout mice by da Mata, Gustavo Eduardo, Bricola, Rafael, Ribeiro, Danielle Naves, Simabuco, Fernando M, Pauli, José R, de Freitas, Ellen C, Ropelle, Eduardo R, da Silva, Adelino S R, Pinto, Ana P

“…The anti-inflammatory role of physical exercise is mediated by interleukin 10 (IL-10), and their release is possibly upregulated in response to IL-6. Previous…”
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Novel processed form of syndecan-1 shed from SCC-9 cells plays a role in cell migration by Aragão, Annelize Z B, Belloni, Marília, Simabuco, Fernando M, Zanetti, Mariana R, Yokoo, Sami, Domingues, Romênia R, Kawahara, Rebeca, Pauletti, Bianca A, Gonçalves, Anderson, Agostini, Michelle, Graner, Edgard, Coletta, Ricardo D, Fox, Jay W, Paes Leme, Adriana F

“…The extracellular milieu is comprised in part by products of cellular secretion and cell surface shedding. The presence of such molecules of the sheddome and…”
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Pomegranate Juice and Peel Extracts are Able to Inhibit Proliferation, Migration and Colony Formation of Prostate Cancer Cell Lines and Modulate the Akt/mTOR/S6K Signaling Pathway by Chaves, Fernanda Machado, Pavan, Isadora Carolina Betim, da Silva, Luiz Guilherme Salvino, de Freitas, Lidia Broglio, Rostagno, Mauricio Ariel, Antunes, Adriane Elisabete Costa, Bezerra, Rosângela Maria Neves, Simabuco, Fernando Moreira

“…Pomegranate ( Punica granatum ) is known to contain polyphenols with many potential health benefits, including anti-tumoral, anti-inflammatory, and…”
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Hypothalamic α7 nicotinic acetylcholine receptor (α7nAChR) is downregulated by TNFα‐induced Let‐7 overexpression driven by fatty acids by Simino, Laís A. P., Baqueiro, Mayara N., Panzarin, Carolina, Lopes, Priscilla K. F., Góis, Mariana M., Simabuco, Fernando M., Ignácio‐Souza, Letícia M., Milanski, Marciane, Ross, Michael G., Desai, Mina, Torsoni, Adriana S., Torsoni, Marcio A.

“…The α7nAChR is crucial to the anti‐inflammatory reflex, and to the expression of neuropeptides that control food intake, but its expression can be decreased by…”
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TLR4-interactor with leucine-rich repeats (TRIL) is involved in diet-induced hypothalamic inflammation by Moura-Assis, Alexandre, Nogueira, Pedro A. S., de-Lima-Junior, Jose C., Simabuco, Fernando M., Gaspar, Joana M., Donato Jr, Jose, Velloso, Licio A.

“…Obesity and high-fat diet (HFD) consumption result in hypothalamic inflammation and metabolic dysfunction. While the TLR4 activation by dietary fats is a…”
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Short-Term Strength Exercise Reduces Hepatic Insulin Resistance in Obese Mice by Reducing PTP1B Content, Regardless of Changes in Body Weight by da Cruz Rodrigues, Kellen Cristina, Martins Pereira, Rodrigo, Peruca, Guilherme Francisco, Torres Barbosa, Lucas Wesley, Ramos Sant'Ana, Marcella, Rosetto Muñoz, Vitor, Morelli, Ana Paula, Moreira Simabuco, Fernando, Sanchez Ramos da Silva, Adelino, Esper Cintra, Dennys, Rochete Ropelle, Eduardo, Pauli, José Rodrigo, de Moura, Leandro Pereira

“…Obesity is closely related to insulin resistance and type 2 diabetes genesis. The liver is a key organ to glucose homeostasis since insulin resistance in this…”
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Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy by Zerbini, Luiz F, Tamura, Rodrigo E, Correa, Ricardo G, Czibere, Akos, Cordeiro, Jason, Bhasin, Manoj, Simabuco, Fernando M, Wang, Yihong, Gu, Xuesong, Li, Linglin, Sarkar, Devanand, Zhou, Jin-Rong, Fisher, Paul B, Libermann, Towia A

“…Several epidemiological studies have correlated the use of non-steroidal anti-inflammatory drugs (NSAID) with reduced risk of ovarian cancer, the most lethal…”
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Exercise Counterbalances Rho/ROCK2 Signaling Impairment in the Skeletal Muscle and Ameliorates Insulin Sensitivity in Obese Mice by Muñoz, Vitor R, Gaspar, Rafael C, Severino, Matheus B, Macêdo, Ana P A, Simabuco, Fernando M, Ropelle, Eduardo R, Cintra, Dennys E, da Silva, Adelino S R, Kim, Young-Bum, Pauli, José Rodrigo

“…Physical exercise is considered a fundamental strategy in improving insulin sensitivity and glucose uptake in skeletal muscle. However, the molecular…”
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Metformin impairs cisplatin resistance effects in A549 lung cancer cells through mTOR signaling and other metabolic pathways by Morelli, Ana Paula, Tortelli, Tharcisio Citrangulo, Jr, Pavan, Isadora Carolina Betim, Silva, Fernando Riback, Granato, Daniela Campos, Peruca, Guilherme Francisco, Pauletti, Bianca Alves, Domingues, Romenia Ramos, Bezerra, Rosangela Maria Neves, de Moura, Leandro Pereira, Leme, Adriana Franco Paes, Chammas, Roger, Simabuco, Fernando Moreira

“…Lung cancer is the leading cause of cancer-associated death worldwide and exhibits intrinsic and acquired therapeutic resistance to cisplatin (CIS). The…”
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Combined physical exercise reverses the reduced expression of Bmal1 in the liver of aged mice by Pinto, Ana P., Muñoz, Vitor R., Tavares, Maria Eduarda A., dos Santos, Jonathas R., Rebelo, Macario A., Alberici, Luciane C., Simabuco, Fernando M., Teixeira, Giovana R., Pauli, José R., de Moura, Leandro P., Cintra, Dennys E., Ropelle, Eduardo R., Freitas, Ellen C., Rivas, Donato A., da Silva, Adelino S.R.

“…Aging can modify the morphology and function of the liver, such as generating a decrease in the mitochondria content, autophagy, and cell senescence. Although…”
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Knockout of NRF2 triggers prostate cancer cells death through ROS modulation and sensitizes to cisplatin by Mancini, Mariana C. S., Morelli, Ana P., Severino, Matheus B., Pavan, Isadora C. B., Zambalde, Érika P., Góis, Mariana M., Silva, Luiz G. S. da, Quintero‐Ruiz, Nathalia, Romeiro, Caio F., Santos, Daniel F. G., Bezerra, Rosângela M. N., Simabuco, Fernando M.

“…Prostate cancer (PCa) represents the second most common cancer in men and affects millions worldwide. Chemotherapy is a common treatment for PCa but the…”
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Strength exercise reduces hepatic pyruvate carboxylase and gluconeogenesis in DIO mice by Pereira, Rodrigo Martins, Rodrigues, Kellen Cristina da Cruz, Sant’Ana, Marcella Ramos, Peruca, Guilherme Francisco, Morelli, Ana Paula, Simabuco, Fernando M, da Silva, Adelino S R, Cintra, Dennys Esper, Ropelle, Eduardo Rochete, Pauli, José Rodrigo, de Moura, Leandro Pereira

“…Obesity is linked to a reduction in the control of hepatic glucose production, which is the primary mechanism related to fasting hyperglycemia and the…”
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