Search Results - "Sima, Jian"

ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes by Rawat, Varun, Wang, Shaowei, Sima, Jian, Bar, Roni, Liraz, Ori, Gundimeda, Usha, Parekh, Trusha, Chan, Jamie, Johansson, Jan O, Tang, Chongren, Chui, Helena C, Harrington, Michael G, Michaelson, Daniel M, Yassine, Hussein N

“…The ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). ApoE protein aggregation plays a central role in AD pathology,…”
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Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases by Yang, Ruihan, Mei, Yilan, Jiang, Yuhan, Li, Huiling, Zhao, Ruixi, Sima, Jian, Yao, Yuyuan

“…Ectodysplasin A (EDA) signaling is initially identified as morphogenic signaling regulating the formation of skin appendages including teeth, hair follicles,…”
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TaqTth-hpRNA: a novel compact RNA-targeting tool for specific silencing of pathogenic mRNA by Xu, Chong, Cao, Jiyanuo, Qiang, Huanran, Liu, Yu, Wu, Jialin, Luo, Qiudan, Wan, Meng, Wang, Yujie, Wang, Peiliang, Cheng, Qian, Zhou, Guohua, Sima, Jian, Guo, Yongjian, Xu, Shu

“…Pathogenic allele silencing is a promising treatment for genetic hereditary diseases. Here, we develop an RNA-cleaving tool, TaqTth-hpRNA, consisting of a…”
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EDA ligand triggers plasma membrane trafficking of its receptor EDAR via PKA activation and SNAP23-containing complexes by Yao, Yuyuan, Yang, Ruihan, Zhu, Jian, Schlessinger, David, Sima, Jian

“…Ectodysplasin-A (EDA), a skin-specific TNF ligand, interacts with its membrane receptor EDAR to trigger EDA signaling in skin appendage formation. Gene…”
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Involvement of Wnt, Eda and Shh at defined stages of sweat gland development by Cui, Chang-Yi, Yin, Mingzhu, Sima, Jian, Childress, Victoria, Michel, Marc, Piao, Yulan, Schlessinger, David

“…To maintain body temperature, sweat glands develop from embryonic ectoderm by a poorly defined mechanism. We demonstrate a temporal cascade of regulation…”
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Salidroside reduces neuropathology in Alzheimer’s disease models by targeting NRF2/SIRT3 pathway by Yao, Yuyuan, Ren, Zhichu, Yang, Ruihan, Mei, Yilan, Dai, Yuying, Cheng, Qian, Xu, Chong, Xu, Xiaogang, Wang, Sanying, Kim, Kyoung Mi, Noh, Ji Heon, Zhu, Jian, Zhao, Ningwei, Liu, Yong U, Mao, Genxiang, Sima, Jian

“…Abstract Background Neurite dystrophy is a pathologic hallmark of Alzheimer’s disease (AD). However, drug discovery targeting neurite protection in AD remains…”
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Edaravone Dexborneol mitigates pathology in animal and cell culture models of Alzheimer's disease by inhibiting neuroinflammation and neuronal necroptosis by Xu, Chong, Mei, Yilan, Yang, Ruihan, Luo, Qiudan, Zhang, Jienian, Kou, Xiaolin, Hu, Jianfeng, Wang, Yujie, Li, Yue, Chen, Rong, Zhang, Zhengping, Yao, Yuyuan, Sima, Jian

“…Alzheimer's disease (AD) is the most prevalent neurodegenerative disease with limited disease-modifying treatments. Drug repositioning strategy has now emerged…”
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Identification of potassium and chloride channels in eccrine sweat glands by Cui, Chang-Yi, Sima, Jian, Yin, Mingzhu, Michel, Marc, Kunisada, Makoto, Schlessinger, David

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Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development by Sima, Jian, Piao, Yulan, Chen, Yaohui, Schlessinger, David

“…Secreted Dickkopf (Dkk) proteins are major Wnt pathway modulators during organ development. Dkk1 has been widely studied and acts as a general Wnt inhibitor…”
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TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG by Xu, Chong, Wu, Jialin, Wu, Yiqun, Ren, Zhichu, Yao, Yuyuan, Chen, Guobing, Fang, Evandro F, Noh, Ji Heon, Liu, Yong U, Wei, Libin, Chen, Xijing, Sima, Jian

“…Neuronal death is a major hallmark of Alzheimer's disease (AD). Necroptosis, as a programmed necrotic process, is activated in AD. However, what signals and…”
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The effect of C-terminal fragment of JNK2 on the stability of p53 and cell proliferation by Yin, Zhi Min, Sima, Jian, Wu, Yi Fan, Zhu, Jian, Jiang, Yong

“…The basal activity of JNK is low in normal growing cells and inactivated JNK targets p53 for ubiquitination. To elucidate if the C-terminal part of JNK is…”
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Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation by Sima, Jian, Yan, Zhijiang, Chen, Yaohui, Lehrmann, Elin, Zhang, Yongqing, Nagaraja, Ramaiah, Wang, Weidong, Wang, Zhong, Schlessinger, David

“…Ectodysplasin A (Eda) signaling activates NF-κB during skin appendage formation, but how Eda controls specific gene transcription remains unclear. Here, we…”
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Semaphorin-3A guides radial migration of cortical neurons during development by Ding, Yu-qiang, Sima, Jian, Wang, Kai-yu, Zheng, Wang, Yuan, Xiao-bing, Xue, Xiao-jing, Chen, Gang, Jin, Ming

“…Postmitotic neurons in the developing cortex migrate along radial glial fibers to their proper location in the cortical plate and form the layered structure…”
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Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation by Xu, Dongyi, Shen, Weiping, Guo, Rong, Xue, Yutong, Peng, Wei, Sima, Jian, Yang, Jay, Sharov, Alexei, Srikantan, Subramanya, Yang, Jiandong, Fox, David, Qian, Yong, Martindale, Jennifer L, Piao, Yulan, Machamer, James, Joshi, Samit R, Mohanty, Subhasis, Shaw, Albert C, Lloyd, Thomas E, Brown, Grant W, Ko, Minoru S H, Gorospe, Myriam, Zou, Sige, Wang, Weidong

“…Topoisomerases are thought to work in DNA, but not RNA, metabolism. Here Xu et al . describe that Top3A can also act as an RNA topoisomerase and find it in a…”
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P1‐188: APOE4 TRAPS ABCA1 IN ENDOSOMES AND IMPAIRS ITS CHOLESTEROL EFFLUX FUNCTION by Sima, Jian, Rawat, Varun, Liraz, Ori, Gundimeda, Usha, Parekh, Trusha, Wang, Shaowei, Johansson, Jan O., Chui, Helena C., Harrington, Michael G., Michaelson, Daniel M., Yassine, Hussein N.

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APOE4 TRAPS ABCA1 IN ENDOSOMES AND IMPAIRS ITS CHOLESTEROL EFFLUX FUNCTION by Sima, Jian, Rawat, Varun, Liraz, Ori, Gundimeda, Usha, Parekh, Trusha, Wang, Shaowei, Johansson, Jan O., Chui, Helena C., Harrington, Michael G., Michaelson, Daniel M., Yassine, Hussein N.

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Top3[beta] is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation by Xu, Dongyi, Shen, Weiping, Guo, Rong, Xue, Yutong, Peng, Wei, Sima, Jian, Yang, Jay, Sharov, Alexei, Srikantan, Subramanya, Yang, Jiandong, Fox, David, Qian, Yong, Martindale, Jennifer L, Piao, Yulan, Machamer, James, Joshi, Samit R, Mohanty, Subhasis, Shaw, Albert C, Lloyd, Thomas E, Brown, Grant W, Ko, Minoru S H, Gorospe, Myriam, Zou, Sige, Wang, Weidong

“…Topoisomerases are crucial for solving DNA topological problems, but they have not been linked to RNA metabolism. Here we show that human topoisomerase 3[beta]…”
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Identification of the involvement of LOXL4 in generation of keratocystic odontogenic tumors by RNA-Seq analysis by Jiang, Wei-Peng, Sima, Zi-Han, Wang, Hai-Cheng, Zhang, Jian-Yun, Sun, Li-Sha, Chen, Feng, Li, Tie-Jun

“…Keratocystic odontogenic tumors （KCOT） are benign, locally aggressive intraosseous tumors of odontogenic origin. KCOT have a higher stromal microvessel density…”
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The effects of cysteines on the function of human glutathion S-transferase pi(GSTp) under cell oxidative stress by Sima, Jian, He, Lan, Zhu, Jian, Xue, Bin, Tai, Yi Lin, Zhang, Shuang Quan, Yin, Zhi Min

“…Site-directed mutagenesis was used to generate three cysteine mutants of GSTp, C(47/101), C(14/47/101) and C(14/47/101/169). GSTp, C(47/101), C(14/47/101) and…”
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