Skin cancer and new treatment perspectives: A review

Highlights • State of the art: technologies that may fit in the clinical practice are overviewed. • New treatment options, prompted by the growing incidence of skin cancer, are discussed. • Strategies from nanotechnology and immunotherapy are also focused on.

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Bibliographic Details
Published in:	Cancer letters Vol. 357; no. 1; pp. 8 - 42
Main Authors:	Simões, M.C.F, Sousa, J.J.S, Pais, A.A.C.C
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01-02-2015 Elsevier Limited
Subjects:	Apoptosis Cell division Hematology, Oncology and Palliative Medicine Humans Immunotherapy Immunotherapy - methods Medical prognosis Melanoma Mens health Mortality Nanoparticles Nanoparticles - administration & dosage Phototherapy Phototherapy - methods Plasma Polymers Skin cancer Skin Neoplasms - pathology Skin Neoplasms - therapy Tumors Women Europe carbon nanotube phosphatidylinositol-3-kinases EPT TNF nanomaterial-mediated photodynamic therapy modular nanotransporter QD PI3K SLN nonmelanocytic skin cancer nuclear factor kappa-light-chain-enhancer of activated B cells Toll-like receptor NSC tyrosine-protein kinase kit T4N5 BCC IL TRAIL nanoparticle TGF nanostructured lipid carrier epidermal growth factor silica nanoparticle dendritic cell solid lipid nanoparticle neural stem cell programmed cell death protein 1 CNP NLC MRI photodynamic therapy CNT GNP RTK heat shock protein hyaluronic acid nsPEF mitogen-activated protein kinase Nanoparticles nanosecond pulsed electric fields near-infrared NLS PD-L1 cyclooxygenase II MSC programmed cell death ligand 1 SKP1-CUL1-F-box protein cerium oxide nanoparticle nanomaterial-mediated photothermal therapy MSH CM NMSC cold atmospheric plasma cell-penetrating peptide Phototherapy 5-fluorouracil magnetic-based core–shell particle tumor necrosis factor TAA ECT MBCSP antigen presenting cell receptor tyrosine kinase 5-aminolevulinic acid 5-FU DC ISPI CPP protein transduction domain tumor-associated antigen electroporation therapy tumor growth factor magnetic resonance-guided focused ultrasound Skin cancer NF-κB nanoscale graphene oxide Immunotherapy Polymers cytotoxic T-lymphocyte-associated antigen 4 US SiNP polyethylene glycol Hsp MAPK T4 endonuclease 5 HIFU CAP poly(D,L lactic-co-glycolic acid) cutaneous malignant melanoma NGO ROS basal cell carcinoma PD-1 PTD magnetic resonance imaging NP COX-2 c-KIT gold nanoparticle melanocyte-stimulating hormone MNP polyethylenimine IFN PTT magnetic nanoparticle MNT reactive oxygen species in situ photoimmunotherapy CTLA-4 MRgFUS TNF-related apoptosis-inducing ligand TLR interleukin NmPDT 5-ALA mesenchymal stem cell PDT EGF electrochemotherapy interferon NmPTT nuclear localization sequence ultrasound SCC PEG PLGA APC PEI NIR photothermal therapy SCF quantum dot HA high intensity focused ultrasound squamous cell carcinoma
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Description
Summary:	Highlights • State of the art: technologies that may fit in the clinical practice are overviewed. • New treatment options, prompted by the growing incidence of skin cancer, are discussed. • Strategies from nanotechnology and immunotherapy are also focused on.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.11.001