Search Results - "Simón‐Fuentes, Miriam"

CD28 is expressed by macrophages with anti‐inflammatory potential and limits their T‐cell activating capacity by Estrada‐Capetillo, Lizbeth, Aragoneses‐Fenoll, Laura, Domínguez‐Soto, Ángeles, Fuentelsaz‐Romero, Sara, Nieto, Concha, Simón‐Fuentes, Miriam, Alonso, Bárbara, Portolés, Pilar, Corbí, Angel L., Rojo, Jose M., Puig‐Kröger, Amaya

“…CD28 expression is generally considered to be T lymphocyte specific. We have previously shown CD28 mRNA expression in M‐CSF‐dependent anti‐inflammatory…”
Get full text

MAFB and MAF Transcription Factors as Macrophage Checkpoints for COVID-19 Severity by Vega, Miguel A, Simón-Fuentes, Miriam, González de la Aleja, Arturo, Nieto, Concha, Colmenares, María, Herrero, Cristina, Domínguez-Soto, Ángeles, Corbí, Ángel L

“…Defective IFN production and exacerbated inflammatory and pro-fibrotic responses are hallmarks of SARS-CoV-2 infection in severe COVID-19. Based on these…”
Get full text

TLR7 Activation in M-CSF-Dependent Monocyte-Derived Human Macrophages Potentiates Inflammatory Responses and Prompts Neutrophil Recruitment by Simón-Fuentes, Miriam, Herrero, Cristina, Acero-Riaguas, Lucia, Nieto, Concha, Lasala, Fatima, Labiod, Nuria, Luczkowiak, Joanna, Alonso, Bárbara, Delgado, Rafael, Colmenares, Maria, Corbí, Ángel L., Domínguez-Soto, Ángeles

“…Abstract Toll-like receptor 7 (TLR7) is an endosomal pathogen-associated molecular pattern (PAMP) receptor that senses single-stranded RNA (ssRNA) and whose…”
Get full text

The Gene Signature of Activated M-CSF-Primed Human Monocyte-Derived Macrophages Is IL-10-Dependent by Cuevas, Víctor D., Simón-Fuentes, Miriam, Orta-Zavalza, Emmanuel, Samaniego, Rafael, Sánchez-Mateos, Paloma, Escribese, María, Cimas, Francisco J., Bustos, Matilde, Pérez-Diego, Mario, Ocaña, Alberto, Domínguez-Soto, Ángeles, Vega, Miguel A., Corbí, Ángel L.

“…During inflammatory responses, monocytes are recruited into inflamed tissues, where they become monocyte-derived macrophages and acquire pro-inflammatory and…”
Get full text

IVIg Promote Cross-Tolerance against Inflammatory Stimuli In Vitro and In Vivo by Domínguez-Soto, Ángeles, Simón-Fuentes, Miriam, de Las Casas-Engel, Mateo, Cuevas, Víctor D, López-Bravo, María, Domínguez-Andrés, Jorge, Saz-Leal, Paula, Sancho, David, Ardavín, Carlos, Ochoa-Grullón, Juliana, Sánchez-Ramón, Silvia, Vega, Miguel A, Corbí, Angel L

“…IVIg is an approved therapy for immunodeficiency and for several autoimmune and inflammatory diseases. However, the molecular basis for the IVIg…”
Get full text

GSK3β Inhibition Prevents Macrophage Reprogramming by High-Dose Methotrexate by Ríos, Israel, López-Navarro, Baltasar, Torres-Torresano, Mónica, Soler Palacios, Blanca, Simón-Fuentes, Miriam, Domínguez-Soto, Ángeles, Muller, Ittai B., Jansen, Gerrit, Corbí, Ángel L., Puig-Kröger, Amaya

“…Abstract Methotrexate (MTX) is an antifolate drug used as a chemotherapeutic agent for acute lymphoblastic leukemia, where MTX improves patients’ prognosis…”
Get full text

Macrophage re-programming by JAK inhibitors relies on MAFB by López-Navarro, Baltasar, Simón-Fuentes, Miriam, Ríos, Israel, Schiaffino, María Teresa, Sanchez, Alicia, Torres-Torresano, Mónica, Nieto-Valle, Alicia, Castrejón, Isabel, Puig-Kröger, Amaya

“…Monocyte-derived macrophages play a key pathogenic role in inflammatory diseases. In the case of rheumatoid arthritis (RA), the presence of specific synovial…”
Get full text

Impaired control of multiple viral infections in a family with complete IRF9 deficiency by Bravo García-Morato, María, Calvo Apalategi, Ane, Bravo-Gallego, Luz Yadira, Blázquez Moreno, Alfonso, Simón-Fuentes, Miriam, Garmendia, Jenny V., Méndez Echevarría, Ana, del Rosal Rabes, Teresa, Domínguez-Soto, Ángeles, López-Granados, Eduardo, Reyburn, Hugh T., Rodríguez Pena, Rebeca

“…Because STAT1 was phosphorylated after IFN-α stimulation of primary fibroblasts from healthy control subjects and patients, the initial steps of the signaling…”
Get full text

Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis by Domínguez-Soto, Ángeles, Usategui, Alicia, Casas-Engel, Mateo de las, Simón-Fuentes, Miriam, Nieto, Concha, Cuevas, Víctor D., Vega, Miguel A., Luis Pablos, José, Corbí, Ángel L.

“…Peripheral serotonin (5-hydroxytryptamine, 5-HT) regulates cell growth and differentiation in numerous cell types through engagement of seven types of cell…”
Get full text

Intravenous Immunoglobulins Promote an Expansion of Monocytic Myeloid-Derived Suppressor Cells (MDSC) in CVID Patients by Simón-Fuentes, Miriam, Sánchez-Ramón, Silvia, Fernández-Paredes, Lidia, Alonso, Bárbara, Guevara-Hoyer, Kissy, Vega, Miguel A., Corbí, Angel L., Domínguez-Soto, Ángeles

“…Common variable immunodeficiency disorders (CVID), the most common primary immune deficiency, includes heterogeneous syndromes characterized by…”
Get full text

MAFB shapes human monocyte-derived macrophage response to SARS-CoV-2 and controls severe COVID-19 biomarker expression by Simón-Fuentes, Miriam, Ríos, Israel, Herrero, Cristina, Lasala, Fátima, Labiod, Nuria, Luczkowiak, Joanna, Roy-Vallejo, Emilia, Fernández de Córdoba-Oñate, Sara, Delgado-Wicke, Pablo, Bustos, Matilde, Fernández-Ruiz, Elena, Colmenares, Maria, Puig-Kröger, Amaya, Delgado, Rafael, Vega, Miguel A, Corbí, Ángel L, Domínguez-Soto, Ángeles

“…Monocyte-derived macrophages, the major source of pathogenic macrophages in COVID-19, are oppositely instructed by macrophage CSF (M-CSF) or granulocyte…”
Get full text

Impaired control of multiple viral infections in a family with complete IRF9 deficiency by Bravo García-Morato, María, Calvo Apalategi, Ane, Bravo-Gallego, Luz Yadira, Blázquez Moreno, Alfonso, Simón-Fuentes, Miriam, Garmendia, Jenny V, Méndez Echevarría, Ana, Del Rosal Rabes, Teresa, Domínguez-Soto, Ángeles, López-Granados, Eduardo, Reyburn, Hugh T, Rodríguez Pena, Rebeca

Get full text