Search Results - "Sim, SC"

Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects by Sim, S C, Kacevska, M, Ingelman-Sundberg, M

“…Interindividual differences in drug disposition are important causes for adverse drug reactions and lack of drug response. The majority of phase I and phase II…”
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Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects by Ingelman-Sundberg, Magnus, Sim, Sarah C, Gomez, Alvin, Rodriguez-Antona, Cristina

“…The polymorphic nature of the cytochrome P450 (CYP) genes affects individual drug response and adverse reactions to a great extent. This variation includes…”
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Pharmacogenomic biomarkers: new tools in current and future drug therapy by Sim, Sarah C, Ingelman-Sundberg, Magnus

“…The rapid development of techniques in the area of genome analysis has facilitated identification of new pharmacogenomic biomarkers that can provide predictive…”
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A common novel CTP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants by Sim, SC, Risinger, C, Dahl, ML, Aklillu, E, Christensen, M, Bertilsson, L, Ingelman-Sundberg, M

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CYP1A21F contains the-163C > A substitution and is highly inducible by Sim, SC

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Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting by Kalman, LV, Agúndez, JAG, Appell, M Lindqvist, Black, JL, Bell, GC, Boukouvala, S, Bruckner, C, Bruford, E, Caudle, K, Coulthard, SA, Daly, AK, Tredici, AL Del, den Dunnen, JT, Drozda, K, Everts, RE, Flockhart, D, Freimuth, RR, Gaedigk, A, Hachad, H, Hartshorne, T, Ingelman-Sundberg, M, Klein, TE, Lauschke, VM, Maglott, DR, McLeod, HL, McMillin, GA, Meyer, UA, Müller, DJ, Nickerson, DA, Oetting, WS, Pacanowski, M, Pratt, VM, Relling, MV, Roberts, A, Rubinstein, WS, Sangkuhl, K, Schwab, M, Scott, SA, Sim, SC, Thirumaran, RK, Toji, LH, Tyndale, RF, van Schaik, RHN, Whirl-Carrillo, M, Yeo, KTJ, Zanger, UM

“…This article provides nomenclature recommendations developed by an international workgroup to increase transparency and standardization of pharmacogenetic…”
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A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants by Sim, Sarah C., Risinger, Carl, Dahl, Marja‐Liisa, Aklillu, Eleni, Christensen, Magnus, Bertilsson, Leif, Ingelman‐Sundberg, Magnus

“…Background and Objective Many drugs, including proton pump inhibitors and certain antidepressants, are metabolized by the polymorphic cytochrome P450 (CYP)…”
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Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three‐Dimensional Spheroid Cultures of Primary Human Hepatocytes by Hendriks, Delilah F.G., Vorrink, Sabine U., Smutny, Tomas, Sim, Sarah C., Nordling, Åsa, Ullah, Shahid, Kumondai, Masaki, Jones, Barry C., Johansson, Inger, Andersson, Tommy B., Lauschke, Volker M., Ingelman‐Sundberg, Magnus

“…Cytochrome P450 (CYP) 3A4 induction is an important cause of drug–drug interactions, making early identification of drug candidates with CYP3A4 induction…”
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Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 gene by Persson, A, Sim, S C, Virding, S, Onishchenko, N, Schulte, G, Ingelman-Sundberg, M

“…Selective serotonin reuptake inhibitors, tricyclic antidepressants, various psychoactive drugs, as well as endogenous steroids and cannabinoid-like compounds…”
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The Human Cytochrome P450 (CYP) Allele Nomenclature website: a peer-reviewed database of CYP variants and their associated effects by Sim, Sarah C, Ingelman-Sundberg, Magnus

“…Pharmacogenetics affects both pharmacokinetics and pharmacodynamics, thereby influencing an individual's response to drugs, both in terms of response and…”
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CYP1A21F contains the - 163C >A substitution and is highly inducible (vol 23, pg 104, 2013) by Sim, SC

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CYP1A21E [corrected] contains the -163C>A substitution and is highly inducible by Sim, Sarah C

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Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment by Jukić, M M, Opel, N, Ström, J, Carrillo-Roa, T, Miksys, S, Novalen, M, Renblom, A, Sim, S C, Peñas-Lledó, E M, Courtet, P, Llerena, A, Baune, B T, de Quervain, D J, Papassotiropoulos, A, Tyndale, R F, Binder, E B, Dannlowski, U, Ingelman-Sundberg, M

“…The polymorphic CYP2C19 enzyme metabolizes psychoactive compounds and is expressed in the adult liver and fetal brain. Previously, we demonstrated that the…”
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Update on allele nomenclature for human cytochromes P450 and the Human Cytochrome P450 Allele (CYP-allele) Nomenclature Database by Sim, Sarah C, Ingelman-Sundberg, Magnus

“…Interindividual variability in xenobiotic metabolism and drug response is extensive and genetic factors play an important role in this variation. A majority of…”
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The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19 ☆ 35 and CYP2C19 ☆ 2 Alleles by Chaudhry, AS, Prasad, B, Shirasaka, Y, Fohner, A, Finkelstein, D, Fan, Y, Wang, S, Wu, G, Aklillu, E, Sim, SC

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Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment by Rodriguez-Antona, Cristina, Gomez, Alvin, Karlgren, Maria, Sim, Sarah C, Ingelman-Sundberg, Magnus

“…The cytochromes P450 (CYPs) are very efficient catalysts of foreign compound metabolism and are responsible for the major part of metabolism of clinically…”
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Databases in the area of pharmacogenetics by Sim, Sarah C., Altman, Russ B., Ingelman-Sundberg, Magnus

“…In the area of pharmacogenetics and personalized health care it is obvious that databases, providing important information of the occurrence and consequences…”
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Pharmacogenetic biomarkers as tools for improved drug therapy; emphasis on the cytochrome P450 system by Ingelman-Sundberg, Magnus, Sim, Sarah C.

“…Important interindividual differences in drug pharmacokinetics cause absence of drug response or adverse drug reactions in significant fractions of the…”
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CYP2D6 update: revised nomenclature for CYP2D7/2D6 hybrid genes by Sim, Sarah C, Daly, Ann K, Gaedigk, Andrea

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Association between CYP2C19 polymorphism and depressive symptoms by Sim, Sarah C., Nordin, Linn, Andersson, Therese M.-L., Virding, Susanne, Olsson, Marita, Pedersen, Nancy L., Ingelman-Sundberg, Magnus

“…Cytochrome P450 2C19 (CYP2C19) is a polymorphic enzyme active in the metabolism of for example diazepam and the antidepressants sertraline, citalopram, and…”
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