Search Results - "Sim, Malcolm J W"

T cells discriminate between groups C1 and C2 HLA-C by Sim, Malcolm J W, Stotz, Zachary, Lu, Jinghua, Brennan, Paul, Long, Eric O, Sun, Peter D

“…Dimorphic amino acids at positions 77 and 80 delineate HLA-C allotypes into two groups, C1 and C2, which associate with disease through interactions with C1…”
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TCRs and AI: the future is now by Sim, Malcolm J. W.

“…A preprint by Fast et al. describes TAPIR, a computational tool for predicting TCR–pMHC interactions…”
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High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D by Sim, Malcolm J. W., Lu, Jinghua, Spencer, Matthew, Hopkins, Francis, Tran, Eric, Rosenberg, Steven A., Long, Eric O., Sun, Peter D.

“…Complete cancer regression occurs in a subset of patients following adoptive T cell therapy (ACT) of ex vivo expanded tumor-infiltrating lymphocytes (TILs)…”
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KIR2DL3 and KIR2DL1 show similar impact on licensing of human NK cells by Sim, Malcolm J. W., Stowell, Janet, Sergeant, Ruhena, Altmann, Daniel M., Long, Eric O., Boyton, Rosemary J.

“…Killer cell immunoglobulin‐like receptor/HLA class I (KIR/HLA‐I) combinations are associated with disease risk, implicating functional roles for NK cells…”
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T Cell Recognition of Tumor Neoantigens and Insights Into T Cell Immunotherapy by Sim, Malcolm J W, Sun, Peter D

“…In cancer, non-synonymous DNA base changes alter protein sequence and produce neoantigens that are detected by the immune system. For immune detection,…”
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HLA-F: A New Kid Licensed for Peptide Presentation by Sim, Malcolm J.W., Sun, Peter D.

“…HLA-F, a non-classical MHC molecule, is not known to present peptides. Dulberger et al. (2017) show that HLA-F contains a distinct peptide-binding groove and…”
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A single amino acid change in inhibitory killer cell Ig-like receptor results in constitutive receptor self-association and phosphorylation by Kumar, Santosh, Sarkar, Pabak, Sim, Malcolm J W, Rajagopalan, Sumati, Vogel, Steven S, Long, Eric O

“…Signaling by immunoreceptors is often initiated by phosphorylation of cytosolic tyrosines, which then recruit effector molecules. In the case of MHC class…”
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Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C by Sim, Malcolm J. W., Rajagopalan, Sumati, Altmann, Daniel M., Boyton, Rosemary J., Sun, Peter D., Long, Eric O.

“…Natural killer (NK) cells have an important role in immune defense against viruses and cancer. Activation of human NK cell cytotoxicity toward infected or…”
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Increased HLA‐E expression in white matter lesions in multiple sclerosis by Durrenberger, Pascal F., Webb, Louise V., Sim, Malcolm J. W., Nicholas, Richard S., Altmann, Daniel M., Boyton, Rosemary J.

“…Summary The molecular mechanisms underpinning central nervous system damage in multiple sclerosis (MS) are complex and it is widely accepted that there is an…”
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Identification and structural characterization of a mutant KRAS‐G12V specific TCR restricted by HLA‐A3 by Sim, Malcolm J. W., Hanada, Ken‐ichi, Stotz, Zachary, Yu, Zhiya, Lu, Jinghua, Brennan, Paul, Quastel, Max, Gillespie, Geraldine M., Long, Eric O., Yang, James C., Sun, Peter D.

“…Mutations in KRAS are some of the most common across multiple cancer types and are thus attractive targets for therapy. Recent studies demonstrated that mutant…”
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Canonical and Cross-reactive Binding of NK Cell Inhibitory Receptors to HLA-C Allotypes Is Dictated by Peptides Bound to HLA-C by Sim, Malcolm J W, Malaker, Stacy A, Khan, Ayesha, Stowell, Janet M, Shabanowitz, Jeffrey, Peterson, Mary E, Rajagopalan, Sumati, Hunt, Donald F, Altmann, Daniel M, Long, Eric O, Boyton, Rosemary J

“…Human natural killer (NK) cell activity is regulated by a family of killer cell immunoglobulin-like receptors (KIRs) that bind human leukocyte antigen (HLA)…”
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Autoantigen cross-reactive environmental antigen can trigger multiple sclerosis-like disease by Reynolds, Catherine J, Sim, Malcolm J W, Quigley, Kathryn J, Altmann, Daniel M, Boyton, Rosemary J

“…Multiple sclerosis is generally considered an autoimmune disease resulting from interaction between predisposing genes and environmental factors, together…”
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The Human NK Cell Receptor KIR2DS4 Detects a Conserved Bacterial Epitope Presented by HLA-C by Long, Eric O, Sim, Malcolm J. W.

“…Natural killer (NK) cells are innate immune effector cells regulated by many germline-encoded activating and inhibitory receptors. The DAP12-associated…”
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The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases by Sim, Malcolm J W, Long, Eric O

“…Combinations of the highly polymorphic KIR and HLA-I genes are associated with numerous human diseases. Interpreting these associations requires a molecular…”
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