Search Results - "Sim, L J"

Kappa opioid receptors mediate an initial aversive component of paclitaxel-induced neuropathy by Meade, Julie A., Alkhlaif, Y., Contreras, K. M., Obeng, S., Toma, W., Sim-Selley, L. J., Selley, D. E., Damaj, M. I.

“…Rationale Cancer patients receiving the antineoplastic drug paclitaxel report higher incidences and longer duration of treatment-resistant depression than…”
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Transforming the perioperative medicine care model: The Singapore experience by Sim, Xiu LJ, Kwa, Charlene XW, He, Yingke, Ng, Kai L, Sim, Eileen Y, Abdullah, Hairil R

“…More than 300 million surgeries are performed worldwide annually. Established perioperative centres in the UK, USA and Australia have demonstrated the impact…”
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Molecular analysis of the PArkin co-regulated gene and association with male infertility by Wilson, Gabrielle R., B.Sc.(Hons.), Sim, Marcus L.-J., B.Sc.(Hons.), Brody, Kate M., B.Sc.(Hons.), Taylor, Juliet M., Ph.D, McLachlan, Robert I., Ph.D, O'Bryan, Moira K., Ph.D, Delatycki, Martin B., Ph.D, Lockhart, Paul J., Ph.D

“…Objective To investigate the potential role of PArkin co-regulated gene ( PACRG ) in human male infertility. Design Case-control study. Setting Academic…”
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Region‐dependent attenuation of μ opioid receptor‐mediated G‐protein activation in mouse CNS as a function of morphine tolerance by Sim‐Selley, L J, Scoggins, K L, Cassidy, M P, Smith, L A, Dewey, W L, Smith, F L, Selley, D E

“…Background and purpose: Chronic morphine administration produces tolerance in vivo and attenuation of μ opioid receptor (MOR)‐mediated G‐protein activation…”
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Inhibition of monoacylglycerol lipase reduces nicotine withdrawal by Muldoon, P P, Chen, J, Harenza, J L, Abdullah, R A, Sim‐Selley, L J, Cravatt, B F, Miles, M F, Chen, X, Lichtman, A H, Damaj, M I

“…Background and Purpose Abrupt discontinuation of nicotine, the main psychoactive component in tobacco, induces a withdrawal syndrome in nicotine‐dependent…”
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In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate binding by Sim, L J, Selley, D E, Childers, S R

“…Agonists stimulate guanylyl 5'-[gamma-[35S]thio]-triphosphate (GTP[gamma-35S]) binding to receptor-coupled guanine nucleotide binding protein (G proteins) in…”
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A randomised controlled trial comparing the McGrath® videolaryngoscope with the straight blade laryngoscope when used in adult patients with potential difficult airways by Ng, I., Sim, X. L. J., Williams, D., Segal, R.

“…Summary Studies show that both straight blade laryngoscopy and videolaryngoscopy can improve the view of the larynx when compared with the Macintosh blade…”
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A prospective study to compare the diagnostic performance of breast elastography versus conventional breast ultrasound by Leong, L.C.H, Sim, L.S.J, Lee, Y.S, Ng, F.C, Wan, C.M, Fook-Chong, S.M.C, Jara-Lazaro, A.R, Tan, P.H

“…Aim To compare the diagnostic performance of breast elastography versus conventional ultrasound in the assessment of breast lesions. Materials and methods The…”
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Status epilepticus causes a long-lasting redistribution of hippocampal cannabinoid type 1 receptor expression and function in the rat pilocarpine model of acquired epilepsy by Falenski, K.W, Blair, R.E, Sim-Selley, L.J, Martin, B.R, DeLorenzo, R.J

“…Abstract Activation of the cannabinoid type 1 (CB1) receptor, a major G-protein-coupled receptor in brain, acts to regulate neuronal excitability and has been…”
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Differences in G-protein activation by μ- and δ-opioid, and cannabinoid, receptors in rat striatum by Sim, Laura J, Selley, Dana E, Xiao, Ruoyu, Childers, Steven R

“…Receptor activation of G-proteins can be measured by agonist-stimulated [ 35S]GTPγS binding in the presence of excess guanosine diphosphate (GDP). To determine…”
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mu-Opioid receptor-stimulated guanosine-5'-O-(gamma-thio)-triphosphate binding in rat thalamus and cultured cell lines: signal transduction mechanisms underlying agonist efficacy by Selley, D E, Sim, L J, Xiao, R, Liu, Q, Childers, S R

“…G protein activation by different mu-selective opioid agonists was examined in rat thalamus, SK-N-SH cells, and mu-opioid receptor-transfected mMOR-CHO cells…”
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Statistical Parametric Mapping reveals ligand and region-specific activation of G-proteins by CB1 receptors and non-CB1 sites in the 3D reconstructed mouse brain by Nguyen, P.T., Selley, D.E., Sim-Selley, L.J.

“…CB1 receptors mediate the CNS effects of Δ9-tetrahydrocannabinol and synthetic cannabinoids. Previous studies have investigated cannabinoid-mediated G-protein…”
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Endomorphin‐Stimulated [35S]GTPγS Binding in Rat Brain: Evidence for Partial Agonist Activity at μ‐Opioid Receptors by Sim, Laura J., Liu, Qixu, Childers, Steven R., Selley, Dana E.

“…: Endomorphin‐1 is a peptide whose binding selectivity suggests a role as an endogenous ligand at μ‐opioid receptors. In the present study, the effect of…”
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Patients’ and Caregivers’ Attitudes Toward Deprescribing in Singapore by Kua, Chong-Han, Reeve, Emily, Tan, Doreen S Y, Koh, Tsingyi, Soong, Jie Lin, Sim, Marvin J L, Zhang, Tracy Y, Chen, Yi Rong, Ratnasingam, Vanassa, Mak, Vivienne S L, Lee, Shaun Wen Huey

“…Abstract Background Knowledge of decision-making preference of patients and caregivers is needed to facilitate deprescribing. This study aimed to assess the…”
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Identification of opioid receptor-like (ORL1) peptide-stimulated [35S]GTP gamma S binding in rat brain by Sim, L J, Xiao, R, Childers, S R

“…Recent reports have identified an endogenous peptide ligand for the opioid receptor-like (ORL1) receptor. In the present study, ORL1 peptide-stimulated…”
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Distribution of ORL-1 receptor binding and receptor-activated G-proteins in rat forebrain and their experimental localization in anterior cingulate cortex by Sim-Selley, Laura J., Vogt, Leslie J., Childers, Steven R., Vogt, Brent A.

“…Opioid receptor-like (ORL-1) receptors and ORL-1-activated G-proteins are found in high levels in the forebrain, particularly cingulate cortex, an area…”
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In vitro autoradiographic localization of 5-HT1A receptor-activated G-proteins in the rat brain by SIM, L. J, RUOYU XIAO, CHILDERS, S. R

“…Serotonin 5-HT1A receptors belong to the superfamily of G-protein-coupled receptors. Receptor activation of G-proteins can be determined by agonist-stimulated…”
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Patients’ and Caregivers’ Attitudes Toward Deprescribing in Singapore by Kua, Chong-Han, Reeve, Emily, Tan, Doreen S Y, Koh, Tsingyi, Soong, Jie Lin, Sim, Marvin J L, Zhang, Tracy Y, Chen, Yi Rong, Ratnasingam, Vanassa, Mak, Vivienne S L, Lee, Shaun Wen Huey

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Stratification of Cannabinoid 1 Receptor (CB1R) Agonist Efficacy: Manipulation of CB1R Density through Use of Transgenic Mice Reveals Congruence between In Vivo and In Vitro Assays by Grim, T W, Morales, A J, Gonek, M M, Wiley, J L, Thomas, B F, Endres, G W, Sim-Selley, L J, Selley, D E, Negus, S S, Lichtman, A H

“…Synthetic cannabinoids (SCs) are an emerging class of abused drugs that differ from each other and the phytocannabinoid ∆ -tetrahydrocannabinol (THC) in their…”
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Brain regional differences in CB1 receptor adaptation and regulation of transcription by Lazenka, M.F., Selley, D.E., Sim-Selley, L.J.

“…Cannabinoid CB1 receptors (CB1Rs) are expressed throughout the brain and mediate the central effects of cannabinoids, including Δ9-tetrahydrocannabinol (THC),…”
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