Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility

Psoriasis is a common inflammatory skin disease with complex genetics and different degrees of prevalence across ethnic populations. Here we present the largest trans-ethnic genome-wide meta-analysis (GWMA) of psoriasis in 15,369 cases and 19,517 controls of Caucasian and Chinese ancestries. We iden...

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Bibliographic Details
Published in:	Nature communications Vol. 6; no. 1; p. 6916
Main Authors:	Yin, Xianyong, Low, Hui Qi, Wang, Ling, Li, Yonghong, Ellinghaus, Eva, Han, Jiali, Estivill, Xavier, Sun, Liangdan, Zuo, Xianbo, Shen, Changbing, Zhu, Caihong, Zhang, Anping, Sanchez, Fabio, Padyukov, Leonid, Catanese, Joseph J., Krueger, Gerald G., Duffin, Kristina Callis, Mucha, Sören, Weichenthal, Michael, Weidinger, Stephan, Lieb, Wolfgang, Foo, Jia Nee, Li, Yi, Sim, Karseng, Liany, Herty, Irwan, Ishak, Teo, Yikying, Theng, Colin T. S., Gupta, Rashmi, Bowcock, Anne, De Jager, Philip L., Qureshi, Abrar A., de Bakker, Paul I. W., Seielstad, Mark, Liao, Wilson, Ståhle, Mona, Franke, Andre, Zhang, Xuejun, Liu, Jianjun
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23-04-2015 Nature Publishing Group Nature Pub. Group
Subjects:	49/47 631/1647/2217/2138 692/420/2489/144 692/699/249/1313/1758 Adaptor Proteins, Vesicular Transport - genetics Asian Continental Ancestry Group - genetics Case-Control Studies Core Binding Factor Alpha 2 Subunit - genetics DEAD-box RNA Helicases - genetics European Continental Ancestry Group - genetics Genes, MHC Class I - genetics Genetic Predisposition to Disease Genome-Wide Association Study Humanities and Social Sciences Humans Interferon-Induced Helicase, IFIH1 Interleukin-12 Subunit p40 - genetics Medicin och hälsovetenskap multidisciplinary Psoriasi Psoriasis - genetics Science Science (multidisciplinary) Transcription Factors - genetics Tumor Suppressor Proteins - genetics
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Summary:	Psoriasis is a common inflammatory skin disease with complex genetics and different degrees of prevalence across ethnic populations. Here we present the largest trans-ethnic genome-wide meta-analysis (GWMA) of psoriasis in 15,369 cases and 19,517 controls of Caucasian and Chinese ancestries. We identify four novel associations at LOC144817 , COG6 , RUNX1 and TP63 , as well as three novel secondary associations within IFIH1 and IL12B . Fine-mapping analysis of MHC region demonstrates an important role for all three HLA class I genes and a complex and heterogeneous pattern of HLA associations between Caucasian and Chinese populations. Further, trans-ethnic comparison suggests population-specific effect or allelic heterogeneity for 11 loci. These population-specific effects contribute significantly to the ethnic diversity of psoriasis prevalence. This study not only provides novel biological insights into the involvement of immune and keratinocyte development mechanism, but also demonstrates a complex and heterogeneous genetic architecture of psoriasis susceptibility across ethnic populations. Psoriasis is a common inflammatory skin disease with complex genetics and different degrees of prevalence across ethnic populations. Here Yin et al . conduct a large trans-ethnic genome-wide meta-analysis and identify novel loci that contribute to population-specific susceptibility.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 These authors contributed equally to this work. These authors jointly supervised this work.
ISSN:	2041-1723 2041-1723
DOI:	10.1038/ncomms7916