Search Results - "Sim, Joan A"

Optical control of trimeric P2X receptors and acid-sensing ion channels by Browne, Liam E., Nunes, João P. M., Sim, Joan A., Chudasama, Vijay, Bragg, Laricia, Caddick, Stephen, North, R. Alan

“…P2X receptors are trimeric membrane proteins that function as ion channels gated by extracellular ATP. We have engineered a P2X2 receptor that opens within…”
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Ectodomain Lysines and Suramin Block of P2X1 Receptors by Sim, Joan A., Broomhead, Helen E., North, R. Alan

“…P2X1 receptors belong to a family of cation channels gated by extracellular ATP; they are found inter alia in smooth muscle, platelets, and immune cells…”
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A critical role of TRPM2 channel in Aβ42‐induced microglial activation and generation of tumor necrosis factor‐α by Alawieyah Syed Mortadza, Sharifah, Sim, Joan A., Neubrand, Veronika E., Jiang, Lin‐Hua

“…Amyloid β (Aβ)‐induced neuroinflammation plays an important part in Alzheimer's disease (AD). Emerging evidence supports a role for the transient receptor…”
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Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells by Mortadza, Sharifah Syed, Sim, Joan A., Stacey, Martin, Jiang, Lin-Hua

“…Excessive Zn 2+ causes brain damage via promoting ROS generation. Here we investigated the role of ROS-sensitive TRPM2 channel in H 2 O 2 /Zn 2+ -induced Ca 2+…”
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Signalling mechanisms mediating Zn 2+ -induced TRPM2 channel activation and cell death in microglial cells by Mortadza, Sharifah Syed, Sim, Joan A, Stacey, Martin, Jiang, Lin-Hua

“…Excessive Zn causes brain damage via promoting ROS generation. Here we investigated the role of ROS-sensitive TRPM2 channel in H O /Zn -induced Ca signalling…”
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Purinergic and Store‐Operated Ca2+ Signaling Mechanisms in Mesenchymal Stem Cells and Their Roles in ATP‐Induced Stimulation of Cell Migration by Peng, Hongsen, Hao, Yunjie, Mousawi, Fatema, Roger, Sebastien, Li, Jing, Sim, Joan A., Ponnambalam, Sreenivasan, Yang, Xuebin, Jiang, Lin‐Hua

“…ATP is an extrinsic signal that can induce an increase in the cytosolic Ca2+ level ([Ca2+]c) in mesenchymal stem cells (MSCs). However, the cognate intrinsic…”
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Purinergic and Store-Operated Ca(2+) Signaling Mechanisms in Mesenchymal Stem Cells and Their Roles in ATP-Induced Stimulation of Cell Migration by Peng, Hongsen, Hao, Yunjie, Mousawi, Fatema, Roger, Sebastien, Li, Jing, Sim, Joan A, Ponnambalam, Sreenivasan, Yang, Xuebin, Jiang, Lin-Hua

“…ATP is an extrinsic signal that can induce an increase in the cytosolic Ca(2+) level ([Ca(2+) ]c ) in mesenchymal stem cells (MSCs). However, the cognate…”
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Heterogeneity in the Basic Membrane Properties of Postnatal Gonadotropin-Releasing Hormone Neurons in the Mouse by Sim, Joan A, Skynner, Michael J, Herbison, Allan E

“…The electrophysiological characteristics of unmodified, postnatal gonadotropin-releasing hormone (GnRH) neurons in the female mouse were studied using…”
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Promoter Transgenics Reveal Multiple Gonadotropin-Releasing Hormone-I-Expressing Cell Populations of Different Embryological Origin in Mouse Brain by Skynner, Michael J, Slater, Ruth, Sim, Joan A, Allen, Nick D, Herbison, Allan E

“…Gonadotropin-releasing hormone-I (GnRH-I) is thought to be expressed by a single, highly spatially restricted group of neurons, which originate in the…”
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Reanalysis of P2X7 Receptor Expression in Rodent Brain by Sim, Joan A, Young, Mark T, Sung, Hye-Youn, North, R. Alan, Surprenant, Annmarie

“…P2X receptors are cationic-selective ion channels gated by extracellular ATP. There are seven subunits (P2X1-7), the first six of which are expressed…”
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Role of P2X4 receptors in synaptic strengthening in mouse CA1 hippocampal neurons by Baxter, Andrew W., Choi, Se Joon, Sim, Joan A., North, R. Alan

“…P2X4 receptors are calcium‐permeable cation channels gated by extracellular ATP. They are found close to subsynaptic sites on hippocampal CA1 neurons. We…”
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Altered Hippocampal Synaptic Potentiation in P2X4 Knock-Out Mice by Sim, Joan A, Chaumont, Severine, Jo, Jihoon, Ulmann, Lauriane, Young, Mark T, Cho, Kwangwook, Buell, Gary, North, R. Alan, Rassendren, Francois

“…P2X4 purinergic receptors are calcium-permeable, ATP-activated ion channels. In the CA1 area of the hippocampus, they are located at the subsynaptic membrane…”
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A critical role of TRPM2 channel in Aβ 42 -induced microglial activation and generation of tumor necrosis factor-α by Alawieyah Syed Mortadza, Sharifah, Sim, Joan A, Neubrand, Veronika E, Jiang, Lin-Hua

“…Amyloid β (Aβ)-induced neuroinflammation plays an important part in Alzheimer's disease (AD). Emerging evidence supports a role for the transient receptor…”
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Functional Properties of Five Dictyostelium discoideum P2X Receptors by Baines, Abigail, Parkinson, Katie, Sim, Joan A., Bragg, Laricia, Thompson, Christopher R.L., North, R. Alan

“…The Dictyostelium discoideum genome encodes five proteins that share weak sequence similarity with vertebrate P2X receptors. Unlike vertebrate P2X receptors,…”
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Late postnatal reorganization of GABA(A) receptor signalling in native GnRH neurons by Sim, J A, Skynner, M J, Pape, J R, Herbison, A E

“…The molecular and cellular characteristics of the gonadotropin-releasing hormone (GnRH) neurons have been difficult to ascertain due to their scattered…”
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Direct Regulation of Postnatal GnRH Neurons by the Progesterone Derivative Allopregnanolone in the Mouse by Sim, Joan A, Skynner, Michael J, Herbison, Allan E

“…The mechanisms through which gonadal steroids exert critical feedback actions upon the activity of the GnRH neurons are not understood. We have examined here…”
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A critical role of TRPM2 channel in A[beta]42-induced microglial activation and generation of tumor necrosis factor-[alpha] by Alawieyah Syed Mortadza, Sharifah, Sim, Joan A, Neubrand, Veronika E, Jiang, Lin-Hua

“…Amyloid [beta] (A[beta])-induced neuroinflammation plays an important part in Alzheimer's disease (AD). Emerging evidence supports a role for the transient…”
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Detection of Estrogen Receptor α and β Messenger Ribonucleic Acids in Adult Gonadotropin-Releasing Hormone Neurons1 by Skynner, Michael J, Sim, Joan A, Herbison, Allan E

“…The behavior of the gonadotropin-releasing hormones (GnRH) neurons controlling fertility is dependent upon cyclic fluctuations in circulating concentrations of…”
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Purinergic and Store-Operated Ca super(2+) Signaling Mechanisms in Mesenchymal Stem Cells and Their Roles in ATP-Induced Stimulation of Cell Migration by Peng, Hongsen, Hao, Yunjie, Mousawi, Fatema, Roger, Sebastien, Li, Jing, Sim, Joan A, Ponnambalam, Sreenivasan, Yang, Xuebin, Jiang, Lin-Hua

“…ATP is an extrinsic signal that can induce an increase in the cytosolic Ca super(2+) level ([Ca super(2+)] sub(c)) in mesenchymal stem cells (MSCs). However,…”
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Detection of estrogen receptor alpha and beta messenger ribonucleic acids in adult gonadotropin-releasing hormone neurons by Skynner, M J, Sim, J A, Herbison, A E

“…The behavior of the gonadotropin-releasing hormones (GnRH) neurons controlling fertility is dependent upon cyclic fluctuations in circulating concentrations of…”
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