Search Results - "Sim, Joan"

A critical role of TRPM2 channel in Aβ42‐induced microglial activation and generation of tumor necrosis factor‐α by Alawieyah Syed Mortadza, Sharifah, Sim, Joan A., Neubrand, Veronika E., Jiang, Lin‐Hua

“…Amyloid β (Aβ)‐induced neuroinflammation plays an important part in Alzheimer's disease (AD). Emerging evidence supports a role for the transient receptor…”
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Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells by Mortadza, Sharifah Syed, Sim, Joan A., Stacey, Martin, Jiang, Lin-Hua

“…Excessive Zn 2+ causes brain damage via promoting ROS generation. Here we investigated the role of ROS-sensitive TRPM2 channel in H 2 O 2 /Zn 2+ -induced Ca 2+…”
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Signalling mechanisms mediating Zn 2+ -induced TRPM2 channel activation and cell death in microglial cells by Mortadza, Sharifah Syed, Sim, Joan A, Stacey, Martin, Jiang, Lin-Hua

“…Excessive Zn causes brain damage via promoting ROS generation. Here we investigated the role of ROS-sensitive TRPM2 channel in H O /Zn -induced Ca signalling…”
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Oscillometry in Stable Single and Double Lung Allograft Recipients Transplanted for Interstitial Lung Disease: Results of a Multi-Center Australian Study by Sim, Joan P Y, Nilsen, Kristopher, Borg, Brigitte M, Levvey, Bronwyn, Vazirani, Jaideep, Ennis, Samantha, Plit, Marshall, Snell, Gregory I, Darley, David R, Tonga, Katrina O

“…Peak spirometry after single lung transplantation (SLTx) for interstitial lung disease (ILD) is lower than after double lung transplantation (DLTx), however…”
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A catalogue of tools and variables from crisis and routine care to support decision-making about allocation of intensive care beds and ventilator treatment during pandemics: Scoping review by Cardona, Magnolia, Dobler, Claudia C., Koreshe, Eyza, Heyland, Daren K., Nguyen, Rebecca H., Sim, Joan P.Y., Clark, Justin, Psirides, Alex

“…This scoping review sought to identify objective factors to assist clinicians and policy-makers in making consistent, objective and ethically sound decisions…”
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Purinergic and Store‐Operated Ca2+ Signaling Mechanisms in Mesenchymal Stem Cells and Their Roles in ATP‐Induced Stimulation of Cell Migration by Peng, Hongsen, Hao, Yunjie, Mousawi, Fatema, Roger, Sebastien, Li, Jing, Sim, Joan A., Ponnambalam, Sreenivasan, Yang, Xuebin, Jiang, Lin‐Hua

“…ATP is an extrinsic signal that can induce an increase in the cytosolic Ca2+ level ([Ca2+]c) in mesenchymal stem cells (MSCs). However, the cognate intrinsic…”
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Purinergic and Store-Operated Ca(2+) Signaling Mechanisms in Mesenchymal Stem Cells and Their Roles in ATP-Induced Stimulation of Cell Migration by Peng, Hongsen, Hao, Yunjie, Mousawi, Fatema, Roger, Sebastien, Li, Jing, Sim, Joan A, Ponnambalam, Sreenivasan, Yang, Xuebin, Jiang, Lin-Hua

“…ATP is an extrinsic signal that can induce an increase in the cytosolic Ca(2+) level ([Ca(2+) ]c ) in mesenchymal stem cells (MSCs). However, the cognate…”
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Optical control of trimeric P2X receptors and acid-sensing ion channels by Browne, Liam E., Nunes, João P. M., Sim, Joan A., Chudasama, Vijay, Bragg, Laricia, Caddick, Stephen, North, R. Alan

“…P2X receptors are trimeric membrane proteins that function as ion channels gated by extracellular ATP. We have engineered a P2X2 receptor that opens within…”
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AF-6 Protects Against Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson's Disease by Basil, Adeline H, Sim, Joan P L, Lim, Grace G Y, Lin, Shuping, Chan, Hui Ying, Engelender, Simone, Lim, Kah-Leong

“…Afadin 6 (AF-6) is an F-actin binding multidomain-containing scaffolding protein that is known for its function in cell-cell adhesion. Interestingly, besides…”
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Reanalysis of P2X7 Receptor Expression in Rodent Brain by Sim, Joan A, Young, Mark T, Sung, Hye-Youn, North, R. Alan, Surprenant, Annmarie

“…P2X receptors are cationic-selective ion channels gated by extracellular ATP. There are seven subunits (P2X1-7), the first six of which are expressed…”
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Role of P2X4 receptors in synaptic strengthening in mouse CA1 hippocampal neurons by Baxter, Andrew W., Choi, Se Joon, Sim, Joan A., North, R. Alan

“…P2X4 receptors are calcium‐permeable cation channels gated by extracellular ATP. They are found close to subsynaptic sites on hippocampal CA1 neurons. We…”
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Altered Hippocampal Synaptic Potentiation in P2X4 Knock-Out Mice by Sim, Joan A, Chaumont, Severine, Jo, Jihoon, Ulmann, Lauriane, Young, Mark T, Cho, Kwangwook, Buell, Gary, North, R. Alan, Rassendren, Francois

“…P2X4 purinergic receptors are calcium-permeable, ATP-activated ion channels. In the CA1 area of the hippocampus, they are located at the subsynaptic membrane…”
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A critical role of TRPM2 channel in Aβ 42 -induced microglial activation and generation of tumor necrosis factor-α by Alawieyah Syed Mortadza, Sharifah, Sim, Joan A, Neubrand, Veronika E, Jiang, Lin-Hua

“…Amyloid β (Aβ)-induced neuroinflammation plays an important part in Alzheimer's disease (AD). Emerging evidence supports a role for the transient receptor…”
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Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity by Sim, Joan Poh Ling, Ziyin, Wang, Basil, Adeline Henry, Lin, Shuping, Chen, Zhongcan, Zhang, Chengwu, Zeng, Li, Cai, Yu, Lim, Kah-Leong

“…Mutations in LRRK2 are currently recognized as the most common monogenetic cause of Parkinsonism. The elevation of kinase activity of LRRK2 that frequently…”
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Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription by Mok, Sachel, Imwong, Mallika, Mackinnon, Margaret J, Sim, Joan, Ramadoss, Ramya, Yi, Poravuth, Mayxay, Mayfong, Chotivanich, Kesinee, Liong, Kek-Yee, Russell, Bruce, Socheat, Duong, Newton, Paul N, Day, Nicholas P J, White, Nicholas J, Preiser, Peter R, Nosten, François, Dondorp, Arjen M, Bozdech, Zbynek

“…Artemisinin resistance in Plasmodium falciparum malaria has emerged in Western Cambodia. This is a major threat to global plans to control and eliminate…”
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Ectodomain Lysines and Suramin Block of P2X1 Receptors by Sim, Joan A., Broomhead, Helen E., North, R. Alan

“…P2X1 receptors belong to a family of cation channels gated by extracellular ATP; they are found inter alia in smooth muscle, platelets, and immune cells…”
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Functional Properties of Five Dictyostelium discoideum P2X Receptors by Baines, Abigail, Parkinson, Katie, Sim, Joan A., Bragg, Laricia, Thompson, Christopher R.L., North, R. Alan

“…The Dictyostelium discoideum genome encodes five proteins that share weak sequence similarity with vertebrate P2X receptors. Unlike vertebrate P2X receptors,…”
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The BEACH Domain Is Critical for Blue Cheese Function in a Spatial and Epistatic Autophagy Hierarchy by Sim, Joan, Osborne, Kathleen A, Argudo García, Irene, Matysik, Artur S, Kraut, Rachel

“…( ) encodes a BEACH domain adaptor protein that, like its human homolog ALFY, promotes clearance of aggregated proteins through its interaction with Atg5 and…”
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Heterogeneity in the Basic Membrane Properties of Postnatal Gonadotropin-Releasing Hormone Neurons in the Mouse by Sim, Joan A, Skynner, Michael J, Herbison, Allan E

“…The electrophysiological characteristics of unmodified, postnatal gonadotropin-releasing hormone (GnRH) neurons in the female mouse were studied using…”
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Differential Assembly of Rat Purinergic P2X7 Receptor in Immune Cells of the Brain and Periphery by Kim, Miran, Spelta, Valeria, Sim, Joan, North, R. Alan, Surprenant, Annmarie

“…ATP-gated P2X7 purinoceptors are found in most immune cells of the periphery and the brain where their activation leads to multiple downstream events such as…”
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