Search Results - "Sim, Hong May"

Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1) by Chufan, Eduardo E, Kapoor, Khyati, Sim, Hong-May, Singh, Satyakam, Talele, Tanaji T, Durell, Stewart R, Ambudkar, Suresh V

“…P-glycoprotein (Pgp, ABCB1) is an ATP-Binding Cassette (ABC) transporter that is associated with the development of multidrug resistance in cancer cells. Pgp…”
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Human ABCB1 (P-glycoprotein) and ABCG2 mediate resistance to BI 2536, a potent and selective inhibitor of Polo-like kinase 1 by Wu, Chung-Pu, Hsiao, Sung-Han, Sim, Hong-May, Luo, Shi-Yu, Tuo, Wei-Cherng, Cheng, Hsing-Wen, Li, Yan-Qing, Huang, Yang-Hui, Ambudkar, Suresh V.

“…The overexpression of the serine/threonine specific Polo-like kinase 1 (Plk1) has been detected in various types of cancer, and thus has fast become an…”
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Saracatinib (AZD0530) is a potent modulator of ABCB1‐mediated multidrug resistance in vitro and in vivo by Liu, Ke‐Jun, He, Jie‐Hua, Su, Xiao‐Dong, Sim, Hong‐May, Xie, Jing‐Dun, Chen, Xing‐Gui, Wang, Fang, Liang, Yong‐Ju, Singh, Satyakam, Sodani, Kamlesh, Talele, Tanaji T., Ambudkar, Suresh V., Chen, Zhe‐Sheng, Wu, Hai‐Ying, Fu, Li‐Wu

“…Saracatinib, a highly selective, dual Src/Abl kinase inhibitor, is currently in a Phase II clinical trial for the treatment of ovarian cancer. In our study, we…”
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ARRY-334543 Reverses Multidrug Resistance by Antagonizing the Activity of ATP-Binding Cassette Subfamily G Member 2 by Wang, De-Shen, Patel, Atish, Sim, Hong-May, Zhang, Yun-Kai, Wang, Yi-Jun, Kathawala, Rishil J., Zhang, Hui, Talele, Tanaji T., Ambudkar, Suresh V., Xu, Rui-Hua, Chen, Zhe-Sheng

“…ABSTRACT ARRY‐334543 is a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases. We conducted this study to determine whether ARRY‐334543 can enhance…”
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Molecular Basis of the Polyspecificity of P-Glycoprotein (ABCB1): Recent Biochemical and Structural Studies by Chufan, Eduardo E, Sim, Hong-May, Ambudkar, Suresh V

“…ABCB1 (P-glycoprotein/P-gp) is an ATP-binding cassette transporter well known for its association with multidrug resistance in cancer cells. Powered by the…”
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Overexpression of ATP-binding cassette transporter ABCG2 as a potential mechanism of acquired resistance to vemurafenib in BRAF(V600E) mutant cancer cells by Wu, Chung-Pu, Sim, Hong-May, Huang, Yang-Hui, Liu, Yen-Chen, Hsiao, Sung-Han, Cheng, Hsing-Wen, Li, Yan-Qing, Ambudkar, Suresh V., Hsu, Sheng-Chieh

“…Melanoma is the most serious type of skin cancer with a high potential for metastasis and very low survival rates. The discovery of constitutive activation of…”
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A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein-protein interactions identifies a novel putative Mdm2-binding site in p53 by Wong, Jin Huei, Alfatah, Mohammad, Sin, Mei Fang, Sim, Hong May, Verma, Chandra S, Lane, David P, Arumugam, Prakash

“…Protein-protein interactions (PPIs) are fundamental to the growth and survival of cells and serve as excellent targets to develop inhibitors of biological…”
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Dimethoxyaurones: Potent inhibitors of ABCG2 (breast cancer resistance protein) by Sim, Hong-May, Lee, Chong-Yew, Ee, Pui Lai Rachel, Go, Mei-Lin

“…A series of 4,6-dimethoxyaurones were synthesized by reacting 4,6-dimethoxybenzofuran-3(2 H)-one with various benzaldehydes in a base-catalyzed aldol reaction…”
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Conserved Walker A Cysteines 431 and 1074 in Human P‑Glycoprotein Are Accessible to Thiol-Specific Agents in the Apo and ADP-Vanadate Trapped Conformations by Sim, Hong-May, Bhatnagar, Jaya, Chufan, Eduardo E, Kapoor, Khyati, Ambudkar, Suresh V

“…P-Glycoprotein (P-gp) is an ATP-binding cassette efflux transporter involved in the development of multidrug resistance in cancer cells. Although the mechanism…”
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Aurones as Modulators of ABCG2 and ABCB1: Synthesis and Structure-Activity Relationships by Sim, Hong May, Loh, Ker Yun, Yeo, Wee Kiang, Lee, Chong Yew, Go, Mei Lin

“…The ability of aurones to modulate the efflux activities of ABCG2 and ABCB1 was investigated by quantifying their effects on the accumulation of pheophorbide A…”
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In vitro and in vivo modulation of ABCG2 by functionalized aurones and structurally related analogs by Sim, Hong-May, Wu, Chung-Pu, Ambudkar, Suresh V., Go, Mei-Lin

“…Over-expression of ABCG2 is linked to multidrug resistance in cancer chemotherapy. We have previously shown that functionalized aurones effectively reduced the…”
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Synthesis and antimicrobial activity of N-benzyl or N-benzyloxy-1,6-dihydro-1,3,5-triazine-2,4-diamines by XIANG MA, TAN, Soo-Tong, KHOO, Chai-Ling, SIM, Hong-May, CHAN, Lai-Wah, CHUI, Wai-Keung

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Abstract 766: Human ABCB1 and ABCG2 confer acquired resistance to Polo-like kinase 1 inhibitors, BI 2536, volasertib and GSK641364 by Wu, Chung-Pu, Sim, Hong-May, Ambudkar, Suresh V.

“…Abstract The overexpression of the serine/threonine specific polo-like kinase 1 (Plk1) has been detected in various types of cancer, and thus has fast become…”
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Neratinib reverses ATP-binding cassette B1-mediated chemotherapeutic drug resistance in vitro, in vivo, and ex vivo by Zhao, Xiao-qin, Xie, Jing-dun, Chen, Xing-gui, Sim, Hong May, Zhang, Xu, Liang, Yong-ju, Singh, Satyakam, Talele, Tanaji T, Sun, Yueli, Ambudkar, Suresh V, Chen, Zhe-Sheng, Fu, Li-wu

“…Neratinib, an irreversible inhibitor of epidermal growth factor receptor and human epidermal receptor 2, is in phase III clinical trials for patients with…”
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Synthesis and antimicrobial activity of N1-benzyl or N1-benzyloxy-1,6-dihydro-1,3,5-triazine-2,4-diamines by Ma, Xiang, Tan, Soo-Tong, Khoo, Chai-Ling, Sim, Hong-May, Chan, Lai-Wah, Chui, Wai-Keung

“…A series of N1-benzyl and N1-benzyloxy-1,6-dihydro-1,3,5-triazine-2,4-diamine derivatives were synthesized and investigated for their antimicrobial activity…”
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Abstract 898: Probing accessibility and conformational changes in ATP-binding sites during the catalytic cycle of human P-glycoprotein (ABCB1) by Sim, Hong-May, Bhatnagar, Jaya, Green, Samantha A., Gonzalez, Adam, Chufan, Eduardo E., Ambudkar, Suresh V.

“…Abstract P-glycoprotein (P-gp) is an ATP-binding cassette (ABC) efflux transporter implicated in the development of multidrug resistance in cancer cells. The…”
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Abstract LB-222: Chemical and structural flexibility contribute to the broad substrate and modulator specificity of multidrug resistance-linked P-glycoprotein (ABCB1) by Ambudkar, Suresh V., Chufan, Eduardo E., Kapoor, Khyati, Durell, Stewart R., Sim, Hong-May

“…Abstract The human ATP-binding cassette (ABC) transporter ABCB1 (P-glycoprotein, P-gp) mediates efflux of cytotoxic anticancer agents from cells, thereby…”
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Chemical Flexibility of P-Glycoprotein for Interaction with Substrates and Modulators by Chufan, Eduardo E., Kapoor, Khyati, Sim, Hong-May, Durrell, Stewart, Ambudkar, Suresh V.

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Abstract 3398: Overexpression of ATP-binding cassette transporter ABCG2 as a potential mechanism of acquired resistance to vemurafenib in BRAF(V600E) mutant cancer cells by Wu, Chung-Pu, Sim, Hong-May, Huang, Yang-Hui, Liu, Yen-Chen, Hsiao, Sung-Han, Cheng, Hsing-Wen, Li, Yan-Qing, Ambudkar, Suresh, Hsu, Sheng-Chieh

“…Abstract Melanoma is the most serious type of skin cancer with a high potential for metastasis and very low survival rates. The discovery of constitutive…”
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Mapping Conformational Changes Associated with the Catalytic Cycle of Human P-Glycoprotein (ABCB1) by Bhatnagar, Jaya, Sim, Hong-May, Georgieva, Elka, Kapoor, Khyati, Chufan, Eduardo, Ohnuma, Shinobu, Borbat, Peter P., Freed, Jack H., Sauna, Zuben E., Ambudkar, Suresh V.

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