Search Results - "Sim, Fraser J."

Efficient Generation of Myelinating Oligodendrocytes from Primary Progressive Multiple Sclerosis Patients by Induced Pluripotent Stem Cells by Douvaras, Panagiotis, Wang, Jing, Zimmer, Matthew, Hanchuk, Stephanie, O’Bara, Melanie A., Sadiq, Saud, Sim, Fraser J., Goldman, James, Fossati, Valentina

“…Multiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology that affects the CNS. While current therapies are primarily directed against the…”
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CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells by Sim, Fraser J, Goldman, Steven A, McClain, Crystal R, Schanz, Steven J, Protack, Tricia L, Windrem, Martha S

“…Oligodendrocyte progenitors capable of myelination in myelin-deficient mice have been isolated from human fetal brain cells, but at low purity. Sim et al …”
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The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex by Lovatt, Ditte, Sonnewald, Ursula, Waagepetersen, Helle S, Schousboe, Arne, He, Wei, Lin, Jane H.-C, Han, Xiaoning, Takano, Takahiro, Wang, Su, Sim, Fraser J, Goldman, Steven A, Nedergaard, Maiken

“…Protoplasmic astrocytes are critically important to energy metabolism in the CNS. Our current understanding of the metabolic interactions between neurons and…”
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Transcription factor induction of human oligodendrocyte progenitor fate and differentiation by Wang, Jing, Pol, Suyog U, Haberman, Alexa K, Wang, Chunming, O'Bara, Melanie A, Sim, Fraser J

“…Human oligodendrocyte progenitor cell (OPC) specification and differentiation occurs slowly and limits the potential for cell-based treatment of demyelinating…”
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Differential gene expression by endothelial cells under positive and negative streamwise gradients of high wall shear stress by Dolan, Jennifer M, Meng, Hui, Sim, Fraser J, Kolega, John

“…Flow impingement at arterial bifurcations causes high frictional force [or wall shear stress (WSS)], and flow acceleration and deceleration in the branches…”
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Endothelial cells express a unique transcriptional profile under very high wall shear stress known to induce expansive arterial remodeling by Dolan, Jennifer M, Sim, Fraser J, Meng, Hui, Kolega, John

“…Chronic high flow can induce arterial remodeling, and this effect is mediated by endothelial cells (ECs) responding to wall shear stress (WSS). To assess how…”
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Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination by Tripathi, Ajai, Volsko, Christina, Garcia, Jessie P., Agirre, Eneritz, Allan, Kevin C., Tesar, Paul J., Trapp, Bruce D., Castelo-Branco, Goncalo, Sim, Fraser J., Dutta, Ranjan

“…Remyelination requires the generation of new oligodendrocytes (OLs), which are derived from oligodendrocyte progenitor cells (OPCs). Maturation of OPCs into…”
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Oscillatory calcium release and sustained store-operated oscillatory calcium signaling prevents differentiation of human oligodendrocyte progenitor cells by Seidman, Richard A., Khattab, Heba, Polanco, Jessie J., Broome, Jacqueline E., Sim, Fraser J.

“…Endogenous remyelination in demyelinating diseases such as multiple sclerosis is contingent upon the successful differentiation of oligodendrocyte progenitor…”
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Hyaluronan accumulation and arrested oligodendrocyte progenitor maturation in vanishing white matter disease by BUGIANI, Marianna, POSTMA, Nienke, POLDER, Emiel, DIELEMAN, Nikki, SCHEFFER, Peter G, SIM, Fraser J, DER KNAAP, Marjo S. Van, BOOR, Ilja

“…Vanishing white matter disease is a genetic leukoencephalopathy caused by mutations in eukaryotic translation initiation factor 2B. Patients experience a…”
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Anti-muscarinic adjunct therapy accelerates functional human oligodendrocyte repair by Abiraman, Kavitha, Pol, Suyog U, O'Bara, Melanie A, Chen, Guang-Di, Khaku, Zainab M, Wang, Jing, Thorn, David, Vedia, Bansi H, Ekwegbalu, Ezinne C, Li, Jun-Xu, Salvi, Richard J, Sim, Fraser J

“…Therapeutic repair of myelin disorders may be limited by the relatively slow rate of human oligodendrocyte differentiation. To identify appropriate…”
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Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination by Saraswat, Darpan, Shayya, Hani J., Polanco, Jessie J., Tripathi, Ajai, Welliver, R. Ross, Pol, Suyog U., Seidman, Richard A., Broome, Jacqueline E., O’Bara, Melanie A., van Kuppervelt, Toin H., Phillips, Joanna J., Dutta, Ranjan, Sim, Fraser J.

“…Chronic demyelination in the human CNS is characterized by an inhibitory microenvironment that impairs recruitment and differentiation of oligodendrocyte…”
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Paired Related Homeobox Protein 1 Regulates Quiescence in Human Oligodendrocyte Progenitors by Wang, Jing, Saraswat, Darpan, Sinha, Anjali K., Polanco, Jessie, Dietz, Karen, O’Bara, Melanie A., Pol, Suyog U., Shayya, Hani J., Sim, Fraser J.

“…Human oligodendrocyte progenitor cells (hOPCs) persist into adulthood as an abundant precursor population capable of division and differentiation. The…”
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Transcriptional Differences between Normal and Glioma-Derived Glial Progenitor Cells Identify a Core Set of Dysregulated Genes by Auvergne, Romane M., Sim, Fraser J., Wang, Su, Chandler-Militello, Devin, Burch, Jaclyn, Al Fanek, Yazan, Davis, Danielle, Benraiss, Abdellatif, Walter, Kevin, Achanta, Pragathi, Johnson, Mahlon, Quinones-Hinojosa, Alfredo, Natesan, Sridaran, Ford, Heide L., Goldman, Steven A.

“…Glial progenitor cells (GPCs) are a potential source of malignant gliomas. We used A2B5-based sorting to extract tumorigenic GPCs from human gliomas spanning…”
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Histone deacetylase activity is required for human oligodendrocyte progenitor differentiation by Conway, Gregory D., O'Bara, Melanie A., Vedia, Bansi H., Pol, Suyog U., Sim, Fraser J.

“…The molecular mechanisms controlling human oligodendrocyte development are poorly characterized. Microarray analysis of human oligodendrocyte progenitor cells…”
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The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation by Sim, Fraser J, Zhao, Chao, Penderis, Jacques, Franklin, Robin J. M

“…The age-associated decrease in the efficiency of CNS remyelination has clear implications for recovery from demyelinating diseases such as multiple sclerosis…”
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Network-Based Genomic Analysis of Human Oligodendrocyte Progenitor Differentiation by Pol, Suyog U., Polanco, Jessie J., Seidman, Richard A., O'Bara, Melanie A., Shayya, Hani J., Dietz, Karen C., Sim, Fraser J.

“…Impaired human oligodendrocyte progenitor cell (hOPC) differentiation likely contributes to failed remyelination in multiple sclerosis. The characterization of…”
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Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination by Kotter, Mark R., Setzu, Anna, Sim, Fraser J., Van Rooijen, Nico, Franklin, Robin J.M.

“…An association between macrophages and remyelination efficiency has been observed in a variety of different models of CNS demyelination. In order to test…”
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Clemastine Induces Oligodendrocyte Progenitor Pool Exhaustion and Senescence in the Context of Chronic Demyelination in a Rabbit Model by Cooper, James J M, Muthaiah, Rupadevi, Frost, Jon R, Buck, Gregory T, Ravichandar, Roopa, Gadelkarim, Farah, Raymond, Faye D, Sim, Fraser J

“…Clemastine has emerged as a promising therapy for the restoration of neurologic function in patients with multiple sclerosis (MS). However, clemastine and…”
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Dysregulated Cholinergic Signaling Inhibits Oligodendrocyte Maturation Following Demyelination by Ravichandar, Roopa, Gadelkarim, Farah, Muthaiah, Rupadevi, Glynos, Nicolas, Murlanova, Kateryna, Rai, Nagendra K, Saraswat, Darpan, Polanco, Jessie J, Dutta, Ranjan, Pal, Dinesh, Sim, Fraser J

“…Dysregulation of oligodendrocyte progenitor cell (OPC) recruitment and oligodendrocyte differentiation contribute to failure of remyelination in human…”
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p38γ MAPK delays myelination and remyelination and is abundant in multiple sclerosis lesions by Marziali, Leandro N, Hwang, Yoonchan, Palmisano, Marilena, Cuenda, Ana, Sim, Fraser J, Gonzalez, Alberto, Volsko, Christina, Dutta, Ranjan, Trapp, Bruce D, Wrabetz, Lawrence, Feltri, Maria L

“…Multiple sclerosis is a chronic inflammatory disease in which disability results from the disruption of myelin and axons. During the initial stages of the…”
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