Search Results - "Silvio A. Vasconcellos"
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Leptospira interrogans Lsa23 protein recruits plasminogen, factor H and C4BP from normal human serum and mediates C3b and C4b degradation
Published in Microbiology (Society for General Microbiology) (01-02-2016)“…It has been reported that pathogenic Leptospira are resistant to normal human serum (NHS) due to their ability to evade the complement immune system by…”
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2
OmpL1 Is an Extracellular Matrix- and Plasminogen-Interacting Protein of Leptospira spp
Published in Infection and Immunity (01-10-2012)“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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3
New strategies for Leptospira vaccine development based on LPS removal
Published in PloS one (27-03-2020)“…Pathogenic spirochetes from genus Leptospira are etiologic agents of leptospirosis. Cellular vaccines against Leptospira infection often elicit mainly response…”
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4
Immunoprotective Activity Induced by Leptospiral Outer Membrane Proteins in Hamster Model of Acute Leptospirosis
Published in Frontiers in immunology (30-10-2020)“…Leptospirosis is a zoonotic disease of worldwide distribution, affecting both humans and animals. The development of an effective vaccine against leptospirosis…”
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5
Immune response and protective profile elicited by a multi-epitope chimeric protein derived from Leptospira interrogans
Published in International journal of infectious diseases (01-04-2017)“…Summary Introduction Pathogenic Leptospira is the causative agent of leptospirosis, a widely disseminated disease of human and veterinary concern. The…”
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6
Features of two new proteins with OmpA-like domains identified in the genome sequences of Leptospira interrogans
Published in PloS one (07-04-2015)“…Leptospirosis is an acute febrile disease caused by pathogenic spirochetes of the genus Leptospira. It is considered an important re-emerging infectious…”
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The interaction of two novel putative proteins of Leptospira interrogans with E-cadherin, plasminogen and complement components with potential role in bacterial infection
Published in Virulence (01-01-2019)“…Leptospirosis is a worldwide zoonosis caused by pathogenic species of Leptospira. Leptospires are able to adhere to exposed extracellular matrix in injured…”
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Adhesins of Leptospira interrogans mediate the interaction to fibrinogen and inhibit fibrin clot formation in vitro
Published in PLoS neglected tropical diseases (01-08-2013)“…We report in this work that Leptospira strains, virulent L. interrogans serovar Copenhageni, attenuated L. interrogans serovar Copenhageni and saprophytic L…”
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Plasminogen Acquisition and Activation at the Surface of Leptospira Species Lead to Fibronectin Degradation
Published in Infection and Immunity (01-09-2009)“…Pathogenic Leptospira species are the etiological agents of leptospirosis, a widespread disease of human and veterinary concern. In this study, we report that…”
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Characterization of three novel adhesins of Leptospira interrogans
Published in The American journal of tropical medicine and hygiene (01-12-2013)“…We report cloning, expression, purification, and characterization of three predicted leptospiral membrane proteins (LIC11360, LIC11009, and LIC11975). In…”
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In vitro identification of novel plasminogen-binding receptors of the pathogen Leptospira interrogans
Published in PloS one (22-06-2010)“…Leptospirosis is a multisystem disease caused by pathogenic strains of the genus Leptospira. We have reported that Leptospira are able to bind plasminogen…”
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12
Leptospira interrogans reduces fibrin clot formation by modulating human thrombin activity via exosite I
Published in Pathogens and disease (01-06-2015)“…Pathogenic bacteria of the genus Leptospira are the etiological agents of leptospirosis, a disease that affects humans and animals worldwide. Although there…”
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13
Features of two proteins of Leptospira interrogans with potential role in host-pathogen interactions
Published in BMC microbiology (30-03-2012)“…Leptospirosis is considered a re-emerging infectious disease caused by pathogenic spirochaetes of the genus Leptospira. Pathogenic leptospires have the ability…”
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14
Interaction of Leptospira interrogans with Human Proteolytic Systems Enhances Dissemination through Endothelial Cells and Protease Levels
Published in Infection and Immunity (01-05-2013)“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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15
Lsa30, a novel adhesin of Leptospira interrogans binds human plasminogen and the complement regulator C4bp
Published in Microbial pathogenesis (01-09-2012)“…Pathogenic Leptospira is the etiological agent of leptospirosis, a life-threatening disease that affects populations worldwide. Surface proteins have the…”
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Comparative genomics of pathogenic Leptospira interrogans serovar Canicola isolated from swine and human in Brazil
Published in Memórias do Instituto Oswaldo Cruz (01-02-2018)“…Leptospira interrogans serovar Canicola is one of the most important pathogenic serovars for the maintenance of urban leptospirosis. Even though it is…”
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Lsa21, a novel leptospiral protein binding adhesive matrix molecules and present during human infection
Published in BMC microbiology (29-04-2008)“…It has been well documented over past decades that interaction of pathogens with the extracellular matrix (ECM) plays a primary role in host cell attachment…”
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Genomic characterisation of Leptospira inadai serogroup Lyme isolated from captured rat in Brazil and comparative analysis with human reference strain
Published in Memórias do Instituto Oswaldo Cruz (12-03-2018)“…Leptospira inadai is classified as a species of the Leptospira intermediate group that has been poorly studied due to its apparent insignificance to human and…”
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Role of Murine Complement Component C5 in Acute in Vivo Infection by Pathogenic Leptospira interrogans
Published in Frontiers in cellular and infection microbiology (08-03-2018)“…Leptospirosis is considered one of the most important zoonosis worldwide. The activation of the Complement System is important to control dissemination of…”
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Leptospira interrogans serovar copenhageni harbors two lexA genes involved in SOS response
Published in PloS one (03-10-2013)“…Bacteria activate a regulatory network in response to the challenges imposed by DNA damage to genetic material, known as the SOS response. This system is…”
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