Search Results - "Silvin, Aymeric"

Microglia heterogeneity along a spatio–temporal axis: More questions than answers by Silvin, Aymeric, Ginhoux, Florent

“…Microglia are resident macrophages of the central nervous system; they arise during early embryonic development and persist throughout adulthood. These unique…”
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Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development by Utz, Sebastian G., See, Peter, Mildenberger, Wiebke, Thion, Morgane Sonia, Silvin, Aymeric, Lutz, Mirjam, Ingelfinger, Florian, Rayan, Nirmala Arul, Lelios, Iva, Buttgereit, Anne, Asano, Kenichi, Prabhakar, Shyam, Garel, Sonia, Becher, Burkhard, Ginhoux, Florent, Greter, Melanie

“…Central nervous system (CNS) macrophages comprise microglia and border-associated macrophages (BAMs) residing in the meninges, the choroid plexus, and the…”
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Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19 by Silvin, Aymeric, Chapuis, Nicolas, Dunsmore, Garett, Goubet, Anne-Gaëlle, Dubuisson, Agathe, Derosa, Lisa, Almire, Carole, Hénon, Clémence, Kosmider, Olivier, Droin, Nathalie, Rameau, Philippe, Catelain, Cyril, Alfaro, Alexia, Dussiau, Charles, Friedrich, Chloé, Sourdeau, Elise, Marin, Nathalie, Szwebel, Tali-Anne, Cantin, Delphine, Mouthon, Luc, Borderie, Didier, Deloger, Marc, Bredel, Delphine, Mouraud, Severine, Drubay, Damien, Andrieu, Muriel, Lhonneur, Anne-Sophie, Saada, Véronique, Stoclin, Annabelle, Willekens, Christophe, Pommeret, Fanny, Griscelli, Frank, Ng, Lai Guan, Zhang, Zheng, Bost, Pierre, Amit, Ido, Barlesi, Fabrice, Marabelle, Aurélien, Pène, Frédéric, Gachot, Bertrand, André, Fabrice, Zitvogel, Laurence, Ginhoux, Florent, Fontenay, Michaela, Solary, Eric

“…Blood myeloid cells are known to be dysregulated in coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2. It is unknown whether the innate myeloid…”
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Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease by Mulder, Kevin, Patel, Amit Ashok, Kong, Wan Ting, Piot, Cécile, Halitzki, Evelyn, Dunsmore, Garett, Khalilnezhad, Shabnam, Irac, Sergio Erdal, Dubuisson, Agathe, Chevrier, Marion, Zhang, Xiao Meng, Tam, John Kit Chung, Lim, Tony Kiat Hon, Wong, Regina Men Men, Pai, Rhea, Khalil, Ahmed Ibrahim Samir, Chow, Pierce Kah Hoe, Wu, Suny Z., Al-Eryani, Ghamdan, Roden, Daniel, Swarbrick, Alexander, Chan, Jerry Kok Yen, Albani, Salvatore, Derosa, Lisa, Zitvogel, Laurence, Sharma, Ankur, Chen, Jinmiao, Silvin, Aymeric, Bertoletti, Antonio, Blériot, Camille, Dutertre, Charles-Antoine, Ginhoux, Florent

“…Mononuclear phagocytes (MNPs) encompass dendritic cells, monocytes, and macrophages (MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory…”
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Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration by Silvin, Aymeric, Uderhardt, Stefan, Piot, Cecile, Da Mesquita, Sandro, Yang, Katharine, Geirsdottir, Laufey, Mulder, Kevin, Eyal, David, Liu, Zhaoyuan, Bridlance, Cecile, Thion, Morgane Sonia, Zhang, Xiao Meng, Kong, Wan Ting, Deloger, Marc, Fontes, Vasco, Weiner, Assaf, Ee, Rachel, Dress, Regine, Hang, Jing Wen, Balachander, Akhila, Chakarov, Svetoslav, Malleret, Benoit, Dunsmore, Garett, Cexus, Olivier, Chen, Jinmiao, Garel, Sonia, Dutertre, Charles Antoine, Amit, Ido, Kipnis, Jonathan, Ginhoux, Florent

“…Brain macrophage populations include parenchymal microglia, border-associated macrophages, and recruited monocyte-derived cells; together, they control brain…”
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Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration by O’Koren, Emily G., Yu, Chen, Klingeborn, Mikael, Wong, Alicia Y.W., Prigge, Cameron L., Mathew, Rose, Kalnitsky, Joan, Msallam, Rasha A., Silvin, Aymeric, Kay, Jeremy N., Bowes Rickman, Catherine, Arshavsky, Vadim Y., Ginhoux, Florent, Merad, Miriam, Saban, Daniel R.

“…Microglia from different nervous system regions are molecularly and anatomically distinct, but whether they also have different functions is unknown. We…”
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NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation by Lahaye, Xavier, Gentili, Matteo, Silvin, Aymeric, Conrad, Cécile, Picard, Léa, Jouve, Mabel, Zueva, Elina, Maurin, Mathieu, Nadalin, Francesca, Knott, Gavin J., Zhao, Baoyu, Du, Fenglei, Rio, Marlène, Amiel, Jeanne, Fox, Archa H., Li, Pingwei, Etienne, Lucie, Bond, Charles S., Colleaux, Laurence, Manel, Nicolas

“…Detection of viruses by innate immune sensors induces protective antiviral immunity. The viral DNA sensor cyclic GMP-AMP synthase (cGAS) is necessary for…”
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Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing by Decque, Adrien, Joffre, Olivier, Magalhaes, Joao G, Cossec, Jack-Christophe, Blecher-Gonen, Ronnie, Lapaquette, Pierre, Silvin, Aymeric, Manel, Nicolas, Joubert, Pierre-Emmanuel, Seeler, Jacob-Sebastian, Albert, Matthew L, Amit, Ido, Amigorena, Sebastian, Dejean, Anne

“…Sumolyation regulates wide-ranging biological processes, but its influence on innate immunity is unclear. Amigorena and colleagues show that sumoylation…”
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Immune responses during COVID-19 infection by Melenotte, Cléa, Silvin, Aymeric, Goubet, Anne-Gaëlle, Lahmar, Imran, Dubuisson, Agathe, Zumla, Alimuddin, Raoult, Didier, Merad, Mansouria, Gachot, Bertrand, Hénon, Clémence, Solary, Eric, Fontenay, Michaela, André, Fabrice, Maeurer, Markus, Ippolito, Giuseppe, Piacentini, Mauro, Wang, Fu-Sheng, Ginhoux, Florent, Marabelle, Aurélien, Kroemer, Guido, Derosa, Lisa, Zitvogel, Laurence

“…Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV)…”
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Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis by Goubet, Anne-Gaëlle, Dubuisson, Agathe, Geraud, Arthur, Danlos, François-Xavier, Terrisse, Safae, Silva, Carolina Alves Costa, Drubay, Damien, Touri, Lea, Picard, Marion, Mazzenga, Marine, Silvin, Aymeric, Dunsmore, Garett, Haddad, Yacine, Pizzato, Eugenie, Ly, Pierre, Flament, Caroline, Melenotte, Cléa, Solary, Eric, Fontenay, Michaela, Garcia, Gabriel, Balleyguier, Corinne, Lassau, Nathalie, Maeurer, Markus, Grajeda-Iglesias, Claudia, Nirmalathasan, Nitharsshini, Aprahamian, Fanny, Durand, Sylvère, Kepp, Oliver, Ferrere, Gladys, Thelemaque, Cassandra, Lahmar, Imran, Fahrner, Jean-Eudes, Meziani, Lydia, Ahmed-Belkacem, Abdelhakim, Saïdani, Nadia, La Scola, Bernard, Raoult, Didier, Gentile, Stéphanie, Cortaredona, Sébastien, Ippolito, Giuseppe, Lelouvier, Benjamin, Roulet, Alain, Andre, Fabrice, Barlesi, Fabrice, Soria, Jean-Charles, Pradon, Caroline, Gallois, Emmanuelle, Pommeret, Fanny, Colomba, Emeline, Ginhoux, Florent, Kazandjian, Suzanne, Elkrief, Arielle, Routy, Bertrand, Miyara, Makoto, Gorochov, Guy, Deutsch, Eric, Albiges, Laurence, Stoclin, Annabelle, Gachot, Bertrand, Florin, Anne, Merad, Mansouria, Scotte, Florian, Assaad, Souad, Kroemer, Guido, Blay, Jean-Yves, Marabelle, Aurélien, Griscelli, Frank, Zitvogel, Laurence, Derosa, Lisa

“…Patients with cancer are at higher risk of severe coronavirus infectious disease 2019 (COVID-19), but the mechanisms underlying virus–host interactions during…”
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Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication by Lahaye, Xavier, Satoh, Takeshi, Gentili, Matteo, Cerboni, Silvia, Silvin, Aymeric, Conrad, Cécile, Ahmed-Belkacem, Abdelhakim, Rodriguez, Elisa C., Guichou, Jean-François, Bosquet, Nathalie, Piel, Matthieu, Le Grand, Roger, King, Megan C., Pawlotsky, Jean-Michel, Manel, Nicolas

“…During the early phase of replication, HIV reverse transcribes its RNA and crosses the nuclear envelope while escaping host antiviral defenses. The host factor…”
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1510 Multiomic functional biomarkers for cancer prediction and early detection by Fidelle, Marine, Suissa, Deborah, Birebent, Roxanne, Ben-Ahmed, Tarek, de la Varende, Anne-Laure Mallard, Costa Silva, Carolina Alves, Blampey, Quentin, Silvin, Aymeric, Dutertre, Charles-Antoine, Durand, Sylvere, Chen, Hui, Caron, Olivier, Mercier, Olaf, Derosa, Lisa, Kroemer, Guido, Renneville, Aline, Drubay, Damien, Delaloge, Suzette, Boulate, David, Zitvogel, Laurence

“…BackgroundAdulthood cancer results from (epi)genomic cellular changes associated with chronic inflammatory processes and maladaptive immune responses…”
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Expanding cell-to-cell interactions by Silvin, Aymeric, Ginhoux, Florent

“…A new single-cell sequencing approach reveals astrocyte and microglia cross-talk during inflammation High-dimensional single-cell technologies have…”
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Macrophages in health and disease by Park, Matthew D., Silvin, Aymeric, Ginhoux, Florent, Merad, Miriam

“…The heterogeneity of tissue macrophages, in health and in disease, has become increasingly transparent over the last decade. But with the plethora of data…”
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Brain macrophage development, diversity and dysregulation in health and disease by Silvin, Aymeric, Qian, Jiawen, Ginhoux, Florent

“…Brain macrophages include microglia in the parenchyma, border-associated macrophages in the meningeal-choroid plexus-perivascular space, and monocyte-derived…”
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Innate immune sensing of HIV infection by Silvin, Aymeric, Manel, Nicolas

“…Highlights • Innate sensing of HIV-1 is at the interface of viral replication and immune responses. • Innate immune sensing of HIV-1 may contribute to…”
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Cross-presenting CD103+ dendritic cells are protected from influenza virus infection by Helft, Julie, Manicassamy, Balaji, Guermonprez, Pierre, Hashimoto, Daigo, Silvin, Aymeric, Agudo, Judith, Brown, Brian D., Schmolke, Mirco, Miller, Jennifer C., Leboeuf, Marylene, Murphy, Kenneth M., García-Sastre, Adolfo, Merad, Miriam

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Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner by Thion, Morgane Sonia, Low, Donovan, Silvin, Aymeric, Chen, Jinmiao, Grisel, Pauline, Schulte-Schrepping, Jonas, Blecher, Ronnie, Ulas, Thomas, Squarzoni, Paola, Hoeffel, Guillaume, Coulpier, Fanny, Siopi, Eleni, David, Friederike Sophie, Scholz, Claus, Shihui, Foo, Lum, Josephine, Amoyo, Arlaine Anne, Larbi, Anis, Poidinger, Michael, Buttgereit, Anne, Lledo, Pierre-Marie, Greter, Melanie, Chan, Jerry Kok Yen, Amit, Ido, Beyer, Marc, Schultze, Joachim Ludwig, Schlitzer, Andreas, Pettersson, Sven, Ginhoux, Florent, Garel, Sonia

“…Microglia are embryonically seeded macrophages that contribute to brain development, homeostasis, and pathologies. It is thus essential to decipher how…”
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Constitutive Siglec-1 expression confers susceptibility to HIV-1 infection of human dendritic cell precursors by Ruffin, Nicolas, Gea-Mallorquí, Ester, Brouiller, Flavien, Jouve, Mabel, Silvin, Aymeric, See, Peter, Dutertre, Charles-Antoine, Ginhoux, Florent, Benaroch, Philippe

“…The human dendritic cell (DC) lineage has recently been unraveled by high-dimensional mapping, revealing the existence of a discrete new population of blood…”
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Fat‐fated microglial dysfunction by Silvin, Aymeric, Ginhoux, Florent

“…Patients with lysosomal storage disorders (LSDs) exhibit activated microglia in the brain, but the mechanisms underlying microglial activation and contribution…”
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