Search Results - "Silvia CAGGIA"

Sodium L-lactate differently affects brain-derived neurothrophic factor, inducible nitric oxide synthase, and heat shock protein 70 kDa production in human astrocytes and SH-SY5Y cultures by Coco, Marinella, Caggia, Silvia, Musumeci, Giuseppe, Perciavalle, Vincenzo, Graziano, Adriana C.E., Pannuzzo, Giovanna, Cardile, Venera

“…The present study analyzed the in vitro effects induced by sodium L‐lactate on human astrocytes and the SH‐SY5Y cell line, when added at concentrations of 5,…”
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Different mRNA and Protein Expression of Versican in TGF-β1-treated Prostate Cancer Cells by Burak SONER, Eda AÇIKGÖZ, Silvia CAGGIA, Shafiq KHAN, Ayşegül TAŞKIRAN, Gülperi ÖKTEM

“…Objective: Cellular heterogeneity of tumors stems from cell populations expressing a unique set of proteins defective genetic and epigenetic networks. It is…”
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Psoralea glandulosa as a potential source of anticancer agents for melanoma treatment by Madrid, Alejandro, Cardile, Venera, González, César, Montenegro, Ivan, Villena, Joan, Caggia, Silvia, Graziano, Adriana, Russo, Alessandra

“…With the aim of identifying novel agents with antigrowth and pro-apoptotic activity on melanoma cancer, the present study was undertaken to investigate the…”
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New stereoisomeric derivatives of jasmonic acid generated by biotransformation with the fungus Gibberella fujikuroi affect the viability of human cancer cells by Carvajal, Marcela, Espinoza, Luis, Caggia, Silvia, Cardile, Venera, Garbarino, Juan A, Peña-Cortés, Hugo, Russo, Alessandra

“…Background: Several studies have shown that (-)-Jasmonic acid, (+)-7-iso-Jasmonic acid and its methyl ester, methyl jasmonate, have anti-cancer activity in…”
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Development and validation of a sensitive LC-MS/MS assay of GT-14, a novel Gαi2 inhibitor, in rat plasma, and its application in pharmacokinetic study by Sarkar, Mahua, Ma, Jing, Tapadar, Subhasish, Caggia, Silvia, Oyelere, Adegboyega K., Khan, Shafiq A., Xie, Huan

“…A sensitive and selective LC–MS/MS method was developed and validated for the quantitation of a novel Gαi2 inhibitor, GT-14, in rat plasma using a SCIEX 6500+…”
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Development and validation of a sensitive LC-MS/MS assay of GT-14, a novel Gα i 2 inhibitor, in rat plasma, and its application in pharmacokinetic study by Sarkar, Mahua, Ma, Jing, Tapadar, Subhasish, Caggia, Silvia, Oyelere, Adegboyega K, Khan, Shafiq A, Xie, Huan

“…A sensitive and selective LC-MS/MS method was developed and validated for the quantitation of a novel Gα 2 inhibitor, GT-14, in rat plasma using a SCIEX 6500+…”
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Differential roles and activation of mammalian target of rapamycin complexes 1 and 2 during cell migration in prostate cancer cells by Venugopal, Smrruthi Vaidegi, Caggia, Silvia, Gambrell‐Sanders, DaJhnae, Khan, Shafiq A.

“…Background Mammalian target of rapamycin (mTOR) is a downstream substrate activated by PI3K/AKT pathway and it is essential for cell migration. It exists as…”
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Abstract 4596: Synthesis and biological evaluation of small molecules inhibitors targeting heterotrimeric Gαi2 protein by Caggia, Silvia, Garrett, Autumn S., Kumar, Aditi, Tapadar, Subhasish, Oyelere, Adegboyega K., Venugopal, Smrruthi Vaidegi, Khan, Shafiq A.

“…Heterotrimeric G-proteins are ubiquitously expressed in cells, and they transduce signals from activated G-protein coupled receptors. It is well known that…”
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Gα i 2 Protein Inhibition Blocks Chemotherapy- and Anti-Androgen-Induced Prostate Cancer Cell Migration by Caggia, Silvia, Johnston, Alexis, Walunj, Dipak T, Moore, Aanya R, Peer, Benjamin H, Everett, Ravyn W, Oyelere, Adegboyega K, Khan, Shafiq A

“…We have previously shown that heterotrimeric G-protein subunit alphai2 (Gα 2) is essential for cell migration and invasion in prostate, ovarian and breast…”
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Abstract 2669: Chaetoglobosin K, an Akt pathway inhibitor, prevents proliferation and migration of prostate carcinoma cells by Ali, Amna, Caggia, Silvia, Matesic, Diane F., Khan, Shafiq A.

“…Chaetoglobosin K (ChK) is an indolylcytochalasin isolated from the fungus Diplodia macrospora that has shown anti-tumorigenic effects in multiple human lung…”
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Gα[sub.i]2 Protein Inhibition Blocks Chemotherapy- and Anti-Androgen-Induced Prostate Cancer Cell Migration by Caggia, Silvia, Johnston, Alexis, Walunj, Dipak T, Moore, Aanya R, Peer, Benjamin H, Everett, Ravyn W, Oyelere, Adegboyega K, Khan, Shafiq A

“…Chemotherapy is the first line of treatment for malignant tumors. However, recent discoveries have shown that a relapse and the formation of metastatic disease…”
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Mesenchymal stem cells from adipose tissue which have been differentiated into chondrocytes in three-dimensional culture express lubricin by Musumeci, Giuseppe, Lo Furno, Debora, Loreto, Carla, Giuffrida, Rosario, Caggia, Silvia, Leonardi, Rosalia, Cardile, Venera

“…The present study focused on the isolation, cultivation and characterization of human mesenchymal stem cells (MSCs) from adipose tissue and on their…”
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Gαi2 Protein Inhibition Blocks Chemotherapy- and Anti-Androgen-Induced Prostate Cancer Cell Migration by Caggia, Silvia, Johnston, Alexis, Walunj, Dipak T., Moore, Aanya R., Peer, Benjamin H., Everett, Ravyn W., Oyelere, Adegboyega K., Khan, Shafiq A.

“…We have previously shown that heterotrimeric G-protein subunit alphai2 (Gαi2) is essential for cell migration and invasion in prostate, ovarian and breast…”
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Evaluation of monooleine aqueous dispersions as tools for topical administration of curcumin: characterization, in vitro and ex-vivo studies by Puglia, Carmelo, Cardile, Venera, Panico, Anna Maria, Crascì, Lucia, Offerta, Alessia, Caggia, Silvia, Drechsler, Markus, Mariani, Paolo, Cortesi, Rita, Esposito, Elisabetta

“…Curcumin (CUR) is a well-known natural compound showing antioxidant, anti-inflammatory, and antitumor abilities but characterized by poor bioavailability and…”
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Evaluation of new amphiphilic PEG derivatives for preparing stealth lipid nanoparticles by Pignatello, Rosario, Leonardi, Antonio, Pellitteri, Rosalia, Carbone, Claudia, Caggia, Silvia, Graziano, Adriana Carol Eleonora, Cardile, Venera

“…Stealth solid lipid nanoparticles (SLN) were produced using two novel amphiphilic conjugates of mPEG2000 and mPEG5000 carboxylic acids with a C-18 lipoamino…”
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Abstract 4074: Transcription factors involved in the genesis and progression of cancer differently modulated by transforming growth factor-beta3 (TGF-Beta3) in prostate cell lines by Caggia, Silvia, Candido, Saverio, Libra, Massimo, Cardile, Venera

“…Transforming growth factor-beta3 (TGF-β3) is a member of a family of multifunctional cytokines that control different cellular processes including cell…”
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Novel role of Giα2 in cell migration: Downstream of PI3‐kinase–AKT and Rac1 in prostate cancer cells by Caggia, Silvia, Chunduri, HimaBindu, Millena, Ana C., Perkins, Jonathan N., Venugopal, Smrruthi V., Vo, BaoHan T., Li, Chunliang, Tu, Yaping, Khan, Shafiq A.

“…Tumor cell motility is the essential step in cancer metastasis. Previously, we showed that oxytocin and epidermal growth factor (EGF) effects on cell migration…”
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Small Molecule Inhibitors Targeting Gα i 2 Protein Attenuate Migration of Cancer Cells by Caggia, Silvia, Tapadar, Subhasish, Wu, Bocheng, Venugopal, Smrruthi V, Garrett, Autumn S, Kumar, Aditi, Stiffend, Janae S, Davis, John S, Oyelere, Adegboyega K, Khan, Shafiq A

“…Heterotrimeric G-proteins are ubiquitously expressed in several cancers, and they transduce signals from activated G-protein coupled receptors. These proteins…”
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Mineral fibre toxicity: expression of retinoblastoma (Rb) and phospho-retinoblastoma (pRb) protein in alveolar epithelial and mesothelial cell lines exposed to fluoro-edenite fibres by Musumeci, Giuseppe, Cardile, Venera, Fenga, Concettina, Caggia, Silvia, Loreto, Carla

“…Several asbestos-like mineral fibres, including fluoro-edenite, may cause lung cancer and/or other lung diseases. However, biological and molecular mechanisms…”
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Modulation of YY1 and p53 expression by transforming growth factor-β3 in prostate cell lines by Caggia, Silvia, Libra, Massimo, Malaponte, Grazia, Cardile, Venera

“…► TGF-β3 determines the expression of a number of important intracellular signaling pathways in prostate cell lines. ► This study verifies the effects of…”
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