Search Results - "Silvia, C."

Combining radiotherapy and cancer immunotherapy: a paradigm shift by Formenti, Silvia C, Demaria, Sandra

“…The therapeutic application of ionizing radiation has been largely based on its cytocidal power combined with the ability to selectively target tumors…”
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Using immunotherapy to boost the abscopal effect by Ngwa, Wilfred, Irabor, Omoruyi Credit, Schoenfeld, Jonathan D., Hesser, Jürgen, Demaria, Sandra, Formenti, Silvia C.

“…The abscopal effect, which is the regression of metastatic cancer at distant sites during radiotherapy, is somewhat rare but can be promoted by immunotherapy…”
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The abscopal effect 67 years later: from a side story to center stage by Demaria, Sandra, Formenti, Silvia C

“…For over a century, ionising radiation has been used to treat cancer based on its cytotoxic effects on tumour cells. Technical progress has enabled more…”
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Cytosolic DNA Sensing in Organismal Tumor Control by Vanpouille-Box, Claire, Demaria, Sandra, Formenti, Silvia C., Galluzzi, Lorenzo

“…Besides constituting a first layer of defense against microbial challenges, the detection of cytosolic DNA is fundamental for mammalian organisms to control…”
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Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial by Shaverdian, Narek, MD, Lisberg, Aaron E, MD, Bornazyan, Krikor, MD, Veruttipong, Darlene, MPH, Goldman, Jonathan W, MD, Formenti, Silvia C, MD, Garon, Edward B, MD, Lee, Percy, Dr

“…Summary Background Preclinical studies have found radiotherapy enhances antitumour immune responses. We aimed to assess disease control and pulmonary toxicity…”
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The Integration of Radiotherapy with Immunotherapy for the Treatment of Non-Small Cell Lung Cancer by Ko, Eric C, Raben, David, Formenti, Silvia C

“…Five-year survival rates for non-small cell lung cancer (NSCLC) range from 14% to 49% for stage I to stage IIIA disease, and are <5% for stage IIIB/IV disease…”
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Systemic effects of local radiotherapy by Formenti, Silvia C, Dr, Demaria, Sandra, MD

“…Summary Radiotherapy is generally used to treat a localised target that includes cancer. Increasingly, evidence indicates that radiotherapy recruits biological…”
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Immunomodulation by anticancer cell cycle inhibitors by Petroni, Giulia, Formenti, Silvia C., Chen-Kiang, Selina, Galluzzi, Lorenzo

“…Cell cycle proteins that are often dysregulated in malignant cells, such as cyclin-dependent kinase 4 (CDK4) and CDK6, have attracted considerable interest as…”
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Radiation-Induced Chromosomal Aberrations and Immunotherapy: Micronuclei, Cytosolic DNA, and Interferon-Production Pathway by Durante, Marco, Formenti, Silvia C

“…Radiation-induced chromosomal aberrations represent an early marker of late effects, including cell killing and transformation. The measurement of cytogenetic…”
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DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity by Vanpouille-Box, Claire, Alard, Amandine, Aryankalayil, Molykutty J., Sarfraz, Yasmeen, Diamond, Julie M., Schneider, Robert J., Inghirami, Giorgio, Coleman, C. Norman, Formenti, Silvia C., Demaria, Sandra

“…Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. However, the mechanisms by which radiation induces anti-tumour T…”
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Role of Local Radiation Therapy in Cancer Immunotherapy by Demaria, Sandra, Golden, Encouse B, Formenti, Silvia C

“…The recent success of cancer immunotherapy has demonstrated the power of the immune system to clear tumors, generating renewed enthusiasm for identifying ways…”
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Toward Precision Radiotherapy for Use with Immune Checkpoint Blockers by Vanpouille-Box, Claire, Formenti, Silvia C, Demaria, Sandra

“…The first evidence that radiotherapy enhances the efficacy of immune checkpoint blockers (ICB) was obtained a dozen years ago in a mouse model of metastatic…”
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Emerging evidence for adapting radiotherapy to immunotherapy by Galluzzi, Lorenzo, Aryankalayil, Molykutty J., Coleman, C. Norman, Formenti, Silvia C.

“…Immunotherapy has revolutionized the clinical management of many malignancies but is infrequently associated with durable objective responses when used as a…”
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Radiation therapy and anti-tumor immunity: exposing immunogenic mutations to the immune system by Lhuillier, Claire, Rudqvist, Nils-Petter, Elemento, Olivier, Formenti, Silvia C, Demaria, Sandra

“…The expression of antigens that are recognized by self-reactive T cells is essential for immune-mediated tumor rejection by immune checkpoint blockade (ICB)…”
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Cancer and COVID-19 — potentially deleterious effects of delaying radiotherapy by Nagar, Himanshu, Formenti, Silvia C.

“…Radiotherapy can be safely delivered during the coronavirus disease 2019 (COVID-19) pandemic, often through use of hypofractionated regimens, which minimize…”
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Radiation Therapy to Convert the Tumor Into an In Situ Vaccine by Formenti, Silvia C., MD, Demaria, Sandra, MD

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Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer by Petroni, Giulia, Cantley, Lewis C., Santambrogio, Laura, Formenti, Silvia C., Galluzzi, Lorenzo

“…A variety of targeted anticancer agents have been successfully introduced into clinical practice, largely reflecting their ability to inhibit specific…”
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Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control by Lhuillier, Claire, Rudqvist, Nils-Petter, Yamazaki, Takahiro, Zhang, Tuo, Charpentier, Maud, Galluzzi, Lorenzo, Dephoure, Noah, Clement, Cristina C, Santambrogio, Laura, Zhou, Xi Kathy, Formenti, Silvia C, Demaria, Sandra

“…Neoantigens generated by somatic nonsynonymous mutations are key targets of tumor-specific T cells, but only a small number of mutations predicted to be…”
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Optimizing Dose Per Fraction: A New Chapter in the Story of the Abscopal Effect? by Formenti, Silvia C.

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Translational control in cancer by Schneider, Robert J, Silvera, Deborah, Formenti, Silvia C

“…Key Points Alterations in the expression and activity of specific translation factors, and the uncoupling of translational regulation from inhibition by tumour…”
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