Quality of life in osteoporotic women with inadequate clinical response to antiresorptive drugs: results from the ICARO study

Osteoporotic fractures are a major public health problem notably affecting quality of life. The observational, multicenter study ICARO was designed to evaluate inadequate clinical response to antiresorptive drugs. The aim of the present study was to evaluate the impact of the clinical response to tr...

Full description

Saved in:

Bibliographic Details
Published in:	Aging clinical and experimental research Vol. 19; no. 3 Suppl; pp. 24 - 27
Main Authors:	Barbagallo, Mario, Dominguez, Ligia J, Maugeri, Domenico, Isaia, Giancarlo, Silvestri, Santa, Bevilacqua, Maurizio, Adami, Silvano
Format:	Journal Article
Language:	English
Published:	Germany 01-06-2007
Subjects:	Aged Bone Density Conservation Agents - therapeutic use Female Humans Incidence Middle Aged Osteoporosis, Postmenopausal - drug therapy Osteoporosis, Postmenopausal - epidemiology Osteoporosis, Postmenopausal - psychology Patient Compliance Quality of Life Severity of Illness Index Spinal Fractures - epidemiology Spinal Fractures - prevention & control Spinal Fractures - psychology Surveys and Questionnaires Treatment Failure
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Osteoporotic fractures are a major public health problem notably affecting quality of life. The observational, multicenter study ICARO was designed to evaluate inadequate clinical response to antiresorptive drugs. The aim of the present study was to evaluate the impact of the clinical response to treatment on the health-related quality of life in women with postmenopausal osteoporosis. 880 osteoporotic women (mean age 68.0+/-8 years; range 53-79) in treatment with antiresorptive drugs for at least one year were analyzed. All subjects had at least 50% compliance to treatment (i.e., patients took >50% of prescribed doses). The "inadequate clinical response" (ICR), as opposed to "adequate clinical response" (ACR), was defined as the Xrays revealing evident new vertebral or non-vertebral fragility fractures at least 6 months after initiation of antiresorptive therapy. The QUALEFFO- 41 questionnaire was used to evaluate changes in quality of life prospectively. 220 subjects (25%) had an ICR. Non-responders had a higher incidence of multiple vertebral fractures compared with responders. The quality of life data in the study subjects showed a significantly increased score (indicative of lower quality of life) in the total mean score (37.89+/-16.7 vs 45.84+/-18.2, p<0.01), as well as in all the domains/subdomains examined in the QUALEFFO-41 questionnaire in ICR, when compared with ACR. Inadequate clinical response in subjects on antiresorptive drugs is associated with increased severity of the disease and with a significant reduction in the quality of life.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1594-0667