Search Results - "Silverman, michael A."

Impact of Antibiotics on Necrotizing Enterocolitis and Antibiotic-Associated Diarrhea by Silverman, Michael A., MD, PhD, Konnikova, Liza, MD, PhD, Gerber, Jeffrey S., MD, PhD

“…Antibiotic treatment alters the composition and metabolic function of the intestinal microbiota. These alterations may contribute to the pathogenesis of…”
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Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia by Silverman, Michael A, Leroux, Michel R

“…Cilia are organelles that project from most eukaryotic organisms and cell types. Their pervasiveness stems from having remarkably versatile propulsive and…”
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Gene-gene functional relationships in Alzheimer's disease: CELF1 regulates KLC1 alternative splicing by Kikuchi, Masataka, Viet, Justine, Nagata, Kenichi, Sato, Masahiro, David, Geraldine, Audic, Yann, Silverman, Michael A., Yamamoto, Mitsuko, Akatsu, Hiroyasu, Hashizume, Yoshio, Takeda, Shuko, Akamine, Shoshin, Miyamoto, Tesshin, Uozumi, Ryota, Gotoh, Shiho, Mori, Kohji, Ikeda, Manabu, Paillard, Luc, Morihara, Takashi

“…The causes of Alzheimer's disease (AD) are poorly understood, although many genes are known to be involved in this pathology. To gain insights into the…”
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The case for microbial intervention at weaning by Flores, Julia N, Lubin, Jean-Bernard, Silverman, Michael A

“…Weaning, the transition from a milk-based diet to solid food, coincides with the most significant shift in gut microbiome composition in the lifetime of most…”
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Comparison of gnotobiotic communities reveals milk-adapted metabolic functions and unexpected amino acid metabolism by the pre-weaning microbiome by Lubin, Jean-Bernard, Silverman, Michael A, Planet, Paul J

“…The intestinal microbiome during infancy and childhood has distinct metabolic functions and microbial composition compared to adults. We recently published a…”
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Going Too Far Is the Same as Falling Short†: Kinesin-3 Family Members in Hereditary Spastic Paraplegia by Gabrych, Dominik R., Lau, Victor Z., Niwa, Shinsuke, Silverman, Michael A.

“…Proper intracellular trafficking is essential for neuronal development and function, and when any aspect of this process is dysregulated, the resulting…”
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Counter Regulation of Spic by NF-κB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages by Alam, Zahidul, Devalaraja, Samir, Li, Minghong, To, Tsun Ki Jerrick, Folkert, Ian W., Mitchell-Velasquez, Erick, Dang, Mai T., Young, Patricia, Wilbur, Christopher J., Silverman, Michael A., Li, Xinyuan, Chen, Youhai H., Hernandez, Paul T., Bhattacharyya, Aritra, Bhattacharya, Mallar, Levine, Matthew H., Haldar, Malay

“…Activated macrophages must carefully calibrate their inflammatory responses to balance efficient pathogen control with inflammation-mediated tissue damage, but…”
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Pharmacological Inhibition of O‑GlcNAcase Enhances Autophagy in Brain through an mTOR-Independent Pathway by Zhu, Yanping, Shan, Xiaoyang, Safarpour, Farzaneh, Erro Go, Nancy, Li, Nancy, Shan, Alice, Huang, Mina C, Deen, Matthew, Holicek, Viktor, Ashmus, Roger, Madden, Zarina, Gorski, Sharon, Silverman, Michael A, Vocadlo, David J

“…The glycosylation of nucleocytoplasmic proteins with O-linked N-acetylglucosamine residues (O-GlcNAc) is conserved among metazoans and is particularly abundant…”
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Stochastic Subcellular Organization of Dense-Core Vesicles Revealed by Point Pattern Analysis by Robinson, Benjamin J., Stanisavljevic, Bogdan, Silverman, Michael A., Scalettar, Bethe A.

“…Dense-core vesicles (DCVs) are regulated secretory organelles found in many types of neurons. In neurons of the hippocampus, their cargo includes proteins that…”
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Activity-dependent secretion of progranulin from synapses by Petoukhov, Eugenia, Fernando, Sarah, Mills, Fergil, Shivji, Farhan, Hunter, Diana, Krieger, Charles, Silverman, Michael A, Bamji, Shernaz X

“…The secreted growth factor progranulin (PGRN) has been shown to be important for regulating neuronal survival and outgrowth, as well as synapse formation and…”
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Eastern equine encephalitis in children, Massachusetts and New Hampshire,USA, 1970-2010 by Silverman, Michael A, Misasi, John, Smole, Sandra, Feldman, Henry A, Cohen, Adam B, Santagata, Sandro, McManus, Michael, Ahmed, Asim A

“…We describe the clinical, laboratory, and radiographic characteristics of 15 cases of eastern equine encephalitis in children during 1970-2010. The most common…”
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In vivo induction of membrane damage by β-amyloid peptide oligomers by Julien, Carl, Tomberlin, Colson, Roberts, Christine M, Akram, Aumbreen, Stein, Gretchen H, Silverman, Michael A, Link, Christopher D

“…Exposure to the β-amyloid peptide (Aβ) is toxic to neurons and other cell types, but the mechanism(s) involved are still unresolved. Synthetic Aβ oligomers can…”
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Mycalolide B dissociates dynactin and abolishes retrograde axonal transport of dense-core vesicles by Cavolo, Samantha L, Zhou, Chaoming, Ketcham, Stephanie A, Suzuki, Matthew M, Ukalovic, Kresimir, Silverman, Michael A, Schroer, Trina A, Levitan, Edwin S

“…Axonal transport is critical for maintaining synaptic transmission. Of interest, anterograde and retrograde axonal transport appear to be interdependent, as…”
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Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier by Morihara, Takashi, Hayashi, Noriyuki, Yokokoji, Mikiko, Akatsu, Hiroyasu, Silverman, Michael A., Kimura, Nobuyuki, Sato, Masahiro, Saito, Yuhki, Suzuki, Toshiharu, Yanagida, Kanta, Kodama, Takashi S., Tanaka, Toshihisa, Okochi, Masayasu, Tagami, Shinji, Kazui, Hiroaki, Kudo, Takashi, Hashimoto, Ryota, Itoh, Naohiro, Nishitomi, Kouhei, Yamaguchi-Kabata, Yumi, Tsunoda, Tatsuhiko, Takamura, Hironori, Katayama, Taiichi, Kimura, Ryo, Kamino, Kouzin, Hashizume, Yoshio, Takeda, Masatoshi

“…Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ). The genes that govern this process, however, have remained elusive. To this…”
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Home and Community-Based Medicaid Options for Dependent Older Floridians by Golden, Adam G., Roos, Bernard A., Silverman, Michael A., Beers, Mark H.

“…In an era of widespread state budget constraints, Florida has been increasingly challenged to provide long‐term care services to a growing population of older…”
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Cooperation of adapter molecules in proximal signaling cascades during allergic inflammation by Kambayashi, Taku, LaRosa, David F, Silverman, Michael A, Koretzky, Gary A

“…Activation of mast cells through their high-affinity immunoglobulin E receptor (FcεRI) plays an important role in allergic disorders. Other mast…”
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Conversion of Green Fluorescent Protein into a Toxic, Aggregation-prone Protein by C-terminal Addition of a Short Peptide by Link, Christopher D., Fonte, Virginia, Hiester, Brian, Yerg, John, Ferguson, Jmil, Csontos, Susan, Silverman, Michael A., Stein, Gretchen H.

“…A non-natural 16-residue “degron” peptide has been reported to convey proteasome-dependent degradation when fused to proteins expressed in yeast (Gilon, T.,…”
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Arresting microbiome development limits immune system maturation and resistance to infection in mice by Lubin, Jean-Bernard, Green, Jamal, Maddux, Sarah, Denu, Lidiya, Duranova, Tereza, Lanza, Matthew, Wynosky-Dolfi, Meghan, Flores, Julia N., Grimes, Logan P., Brodsky, Igor E., Planet, Paul J., Silverman, Michael A.

“…Disruptions to the intestinal microbiome during weaning lead to negative effects on host immune function. However, the critical host-microbe interactions…”
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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers by Bomfim, Theresa R, Forny-Germano, Leticia, Sathler, Luciana B, Brito-Moreira, Jordano, Houzel, Jean-Christophe, Decker, Helena, Silverman, Michael A, Kazi, Hala, Melo, Helen M, McClean, Paula L, Holscher, Christian, Arnold, Steven E, Talbot, Konrad, Klein, William L, Munoz, Douglas P, Ferreira, Sergio T, De Felice, Fernanda G

“…Defective brain insulin signaling has been suggested to contribute to the cognitive deficits in patients with Alzheimer's disease (AD). Although a connection…”
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Enterococci enhance Clostridioides difficile pathogenesis by Smith, Alexander B., Jenior, Matthew L., Keenan, Orlaith, Hart, Jessica L., Specker, Jonathan, Abbas, Arwa, Rangel, Paula C., Di, Chao, Green, Jamal, Bustin, Katelyn A., Gaddy, Jennifer A., Nicholson, Maribeth R., Laut, Clare, Kelly, Brendan J., Matthews, Megan L., Evans, Daniel R., Van Tyne, Daria, Furth, Emma E., Papin, Jason A., Bushman, Frederic D., Erlichman, Jessi, Baldassano, Robert N., Silverman, Michael A., Dunny, Gary M., Prentice, Boone M., Skaar, Eric P., Zackular, Joseph P.

“…Enteric pathogens are exposed to a dynamic polymicrobial environment in the gastrointestinal tract 1 . This microbial community has been shown to be important…”
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