Search Results - "Silverman, Richard B."

Inducible nitric oxide synthase: Regulation, structure, and inhibition by Cinelli, Maris A., Do, Ha T., Miley, Galen P., Silverman, Richard B.

“…A considerable number of human diseases have an inflammatory component, and a key mediator of immune activation and inflammation is inducible nitric oxide…”
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Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain by Mukherjee, Paramita, Cinelli, Maris A, Kang, Soosung, Silverman, Richard B

“…Nitric oxide (NO) is an important signaling molecule in the human body, playing a crucial role in cell and neuronal communication, regulation of blood…”
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From Basic Science to Blockbuster Drug: The Discovery of Lyrica by Silverman, Richard B

“…The anticonvulsant drug (S)‐(+)‐3‐isobutyl‐γ‐aminobutyric acid ((S)‐(+)‐3‐isobutyl‐GABA, Lyrica; see structure) was developed from a study of fundamental…”
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The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models by Chopra, Vanita, Quinti, Luisa, Kim, Jinho, Vollor, Lorraine, Narayanan, K. Lakshmi, Edgerly, Christina, Cipicchio, Patricia M., Lauver, Molly A., Choi, Soo Hyuk, Silverman, Richard B., Ferrante, Robert J., Hersch, Steven, Kazantsev, Aleksey G.

“…Inhibition of sirtuin 2 (SIRT2) deacetylase mediates protective effects in cell and invertebrate models of Parkinson’s disease and Huntington’s disease (HD)…”
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Potent, Selective, and Membrane Permeable 2‑Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors by Vasu, Dhananjayan, Do, Ha T., Li, Huiying, Hardy, Christine D., Awasthi, Amardeep, Poulos, Thomas L., Silverman, Richard B.

“…A series of potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors (hnNOS), based on a difluorobenzene ring linked to a…”
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CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease by Kang, Soosung, Cooper, Garry, Dunne, Sara F., Dusel, Brendon, Luan, Chi-Hao, Surmeier, D. James, Silverman, Richard B.

“…L-type calcium channels expressed in the brain are heterogeneous. The predominant class of L-type calcium channels has a Ca V 1.2 pore-forming subunit. L-type…”
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The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia by Chen, Xiqun, Wales, Pauline, Quinti, Luisa, Zuo, Fuxing, Moniot, Sébastien, Herisson, Fanny, Rauf, Nazifa Abdul, Wang, Hua, Silverman, Richard B, Ayata, Cenk, Maxwell, Michelle M, Steegborn, Clemens, Schwarzschild, Michael A, Outeiro, Tiago F, Kazantsev, Aleksey G

“…Sirtuin deacetylases regulate diverse cellular pathways and influence disease processes. Our previous studies identified the brain-enriched sirtuin-2 (SIRT2)…”
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Revisiting Heme Mechanisms. A Perspective on the Mechanisms of Nitric Oxide Synthase (NOS), Heme Oxygenase (HO), and Cytochrome P450s (CYP450s) by Zhu, Yaoqiu, Silverman, Richard B

“…Despite the essential biological importance of reactions that involve heme, mechanisms of heme reactions in enzymes like nitric oxide synthase (NOS), heme…”
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Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS) by Tong, Shirley, Cinelli, Maris A., El-Sayed, Naglaa Salem, Huang, He, Patel, Anika, Silverman, Richard B., Yang, Sun

“…Interferon-gamma (IFN-γ) is shown to stimulate melanoma development and progression. However, the underlying mechanism has not been completely defined. Our…”
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Physiological involvement of presynaptic L‐type voltage‐dependent calcium channels in GABA release of cerebellar molecular layer interneurons by Rey, Stéphanie, Maton, Gilliane, Satake, Shin’Ichiro, Llano, Isabel, Kang, Soosung, Surmeier, Dalton James, Silverman, Richard B., Collin, Thibault

“…While high threshold voltage‐dependent Ca2+ channels (VDCCs) of the N and P/Q families are crucial for evoked neurotransmitter release in the mammalian CNS, it…”
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Total Synthesis of Tambromycin Enabled by Indole C–H Functionalization by Miley, Galen P, Rote, Jennifer C, Silverman, Richard B, Kelleher, Neil L, Thomson, Regan J

“…The total synthesis of tambromycin (1), a recently isolated tetrapeptide, is reported. This unusual natural product possesses a highly modified…”
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Stereospecific Total Syntheses of Proteasome Inhibitors Omuralide and Lactacystin by Gu, Wenxin, Silverman, Richard B

“…Omuralide, a transformation product of the microbial metabolite lactacystin, was the first molecule discovered as a specific inhibitor of the proteasome and is…”
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Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule by Trott, Amy, West, James D, Klaić, Lada, Westerheide, Sandy D, Silverman, Richard B, Morimoto, Richard I, Morano, Kevin A

“…Stress response pathways allow cells to sense and respond to environmental changes and adverse pathophysiological states. Pharmacological modulation of…”
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Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3 S ,4 S )-3-Amino-4-fluorocyclopentenecarboxylic Acid by Shen, Sida, Butrin, Arseniy, Beaupre, Brett A, Ferreira, Glaucio M, Doubleday, Peter F, Grass, Daniel H, Zhu, Wei, Kelleher, Neil L, Moran, Graham R, Liu, Dali, Silverman, Richard B

“…Ornithine aminotransferase (OAT) is overexpressed in hepatocellular carcinoma (HCC), and we previously showed that inactivation of OAT inhibits the growth of…”
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Ornithine Aminotransferase versus GABA Aminotransferase: Implications for the Design of New Anticancer Drugs by Lee, Hyunbeom, Juncosa, Jose I., Silverman, Richard B.

“…Ornithine aminotransferase (OAT) and γ‐aminobutyric acid aminotransferase (GABA‐AT) are classified under the same evolutionary subgroup and share a large…”
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NU-9 improves health of hSOD1G93A mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone by Genç, Barış, Gautam, Mukesh, Helmold, Benjamin R., Koçak, Nuran, Günay, Aksu, Goshu, Gashaw M., Silverman, Richard B., Hande Ozdinler, P.

“…Even though amyotrophic lateral sclerosis (ALS) is a disease of the upper and lower motor neurons, to date none of the compounds in clinical trials have been…”
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Hydrophilic, Potent, and Selective 7‑Substituted 2‑Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors by Pensa, Anthony V, Cinelli, Maris A, Li, Huiying, Chreifi, Georges, Mukherjee, Paramita, Roman, Linda J, Martásek, Pavel, Poulos, Thomas L, Silverman, Richard B

“…Neuronal nitric oxide synthase (nNOS) is a target for development of antineurodegenerative agents. Most nNOS inhibitors mimic l-arginine and have poor…”
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Design and Mechanism of GABA Aminotransferase Inactivators. Treatments for Epilepsies and Addictions by Silverman, Richard B

“…When the brain concentration of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) diminishes below a threshold level, the excess neuronal excitation…”
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Structural and biological studies on bacterial nitric oxide synthase inhibitors by Holden, Jeffrey K., Li, Huiying, Jing, Qing, Kang, Soosung, Richo, Jerry, Silverman, Richard B., Poulos, Thomas L.

“…Nitric oxide (NO) produced by bacterial NOS functions as a cytoprotective agent against oxidative stress in Staphylococcus aureus , Bacillus anthracis, and…”
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Celastrols as Inducers of the Heat Shock Response and Cytoprotection[boxs] by Westerheide, Sandy D., Bosman, Joshua D., Mbadugha, Bessie N.A., Kawahara, Tiara L.A., Matsumoto, Gen, Kim, Soojin, Gu, Wenxin, Devlin, John P., Silverman, Richard B., Morimoto, Richard I.

“…Alterations in protein folding and the regulation of conformational states have become increasingly important to the functionality of key molecules in…”
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