Search Results - "Silverman, Richard"

Design and Mechanism of GABA Aminotransferase Inactivators. Treatments for Epilepsies and Addictions by Silverman, Richard B

“…When the brain concentration of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) diminishes below a threshold level, the excess neuronal excitation…”
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Inducible nitric oxide synthase: Regulation, structure, and inhibition by Cinelli, Maris A., Do, Ha T., Miley, Galen P., Silverman, Richard B.

“…A considerable number of human diseases have an inflammatory component, and a key mediator of immune activation and inflammation is inducible nitric oxide…”
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Design of Selective Neuronal Nitric Oxide Synthase Inhibitors for the Prevention and Treatment of Neurodegenerative Diseases by Silverman, Richard B

“…Nitric oxide (NO), which is produced from l-arginine by the nitric oxide synthase (NOS) family of enzymes, is an important second-messenger molecule that…”
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From Basic Science to Blockbuster Drug: The Discovery of Lyrica by Silverman, Richard B

“…The anticonvulsant drug (S)‐(+)‐3‐isobutyl‐γ‐aminobutyric acid ((S)‐(+)‐3‐isobutyl‐GABA, Lyrica; see structure) was developed from a study of fundamental…”
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Inactivators of Ornithine Aminotransferase for the Treatment of Hepatocellular Carcinoma by Silverman, Richard B

“…Hepatocellular carcinoma (HCC) is the second or third leading cause of cancer mortality worldwide (depending on which statistics are used), yet there is no…”
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Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain by Mukherjee, Paramita, Cinelli, Maris A, Kang, Soosung, Silverman, Richard B

“…Nitric oxide (NO) is an important signaling molecule in the human body, playing a crucial role in cell and neuronal communication, regulation of blood…”
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The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia by Chen, Xiqun, Wales, Pauline, Quinti, Luisa, Zuo, Fuxing, Moniot, Sébastien, Herisson, Fanny, Rauf, Nazifa Abdul, Wang, Hua, Silverman, Richard B, Ayata, Cenk, Maxwell, Michelle M, Steegborn, Clemens, Schwarzschild, Michael A, Outeiro, Tiago F, Kazantsev, Aleksey G

“…Sirtuin deacetylases regulate diverse cellular pathways and influence disease processes. Our previous studies identified the brain-enriched sirtuin-2 (SIRT2)…”
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American Academy of Orthopaedic Surgeons Clinical Practice Guideline Case Study: Management of Anterior Cruciate Ligament Injuries by Brophy, Robert H., Silverman, Richard M., Lowry, Kent Jason

“…Considering the frequency of anterior cruciate ligament (ACL) tears, optimal management of these injuries was the subject of a 2022 clinical practice guideline…”
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The 2011 E. B. Hershberg Award for Important Discoveries in Medicinally Active Substances: (1S,3S)-3-Amino-4-difluoromethylenyl-1-cyclopentanoic Acid (CPP-115), a GABA Aminotransferase Inactivator and New Treatment for Drug Addiction and Infantile Spasms by Silverman, Richard B

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The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models by Chopra, Vanita, Quinti, Luisa, Kim, Jinho, Vollor, Lorraine, Narayanan, K. Lakshmi, Edgerly, Christina, Cipicchio, Patricia M., Lauver, Molly A., Choi, Soo Hyuk, Silverman, Richard B., Ferrante, Robert J., Hersch, Steven, Kazantsev, Aleksey G.

“…Inhibition of sirtuin 2 (SIRT2) deacetylase mediates protective effects in cell and invertebrate models of Parkinson’s disease and Huntington’s disease (HD)…”
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Potent, Selective, and Membrane Permeable 2‑Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors by Vasu, Dhananjayan, Do, Ha T., Li, Huiying, Hardy, Christine D., Awasthi, Amardeep, Poulos, Thomas L., Silverman, Richard B.

“…A series of potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors (hnNOS), based on a difluorobenzene ring linked to a…”
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Synthesis of (2R,4S)‑4-Amino-5-hydroxybicyclo[3.1.1]heptane-2-carboxylic Acid via an Asymmetric Intramolecular Mannich Reaction by Dukes, Adrian O., Weerawarna, Pathum M., Devitt, Allison N., Silverman, Richard B.

“…Inhibition of human ornithine aminotransferase interferes with glutamine and proline metabolism in hepatocellular carcinoma, depriving tumors of essential…”
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Improved synthesis and anticancer activity of a potent neuronal nitric oxide synthase inhibitor by Vasu, Dhananjayan, Reidl, Cory T., Wang, Eric, Yang, Sun, Silverman, Richard B.

“…[Display omitted] An improved synthesis of 4-methyl-7-(3-((methylamino)methyl)phenethyl)quinolin-2-amine (1) is reported. A scalable, rapid, and efficient…”
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OV329, a novel highly potent γ‐aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala‐kindled rats by Feja, Malte, Meller, Sebastian, Deking, Lillian S., Kaczmarek, Edith, During, Matthew J., Silverman, Richard B., Gernert, Manuela

“…Summary Objective An attractive target to interfere with epileptic brain hyperexcitability is the enhancement of γ‐aminobutyric acidergic (GABAergic)…”
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Optimization of Blood–Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2‑Aminopyridine Scaffold by Do, Ha T, Li, Huiying, Chreifi, Georges, Poulos, Thomas L, Silverman, Richard B

“…Effective delivery of therapeutic drugs into the human brain is one of the most challenging tasks in central nervous system drug development because of the…”
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2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors by Vasu, Dhananjayan, Li, Huiying, Hardy, Christine D., Poulos, Thomas L., Silverman, Richard B.

“…[Display omitted] A series of potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors (hnNOS) based on the 2-aminopyridine…”
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First Contact: 7‑Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate by Cinelli, Maris A, Reidl, Cory T, Li, Huiying, Chreifi, Georges, Poulos, Thomas L, Silverman, Richard B

“…Inhibition of neuronal nitric oxide synthase (nNOS), an enzyme implicated in neurodegenerative disorders, is an attractive strategy for treating or preventing…”
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CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease by Kang, Soosung, Cooper, Garry, Dunne, Sara F., Dusel, Brendon, Luan, Chi-Hao, Surmeier, D. James, Silverman, Richard B.

“…L-type calcium channels expressed in the brain are heterogeneous. The predominant class of L-type calcium channels has a Ca V 1.2 pore-forming subunit. L-type…”
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Editorial Commentary: Preoperative Patient-Reported Outcomes Measurement Information System Scores Predict Which Patients Will Benefit From Arthroscopic Meniscectomy: To Scope or Not to Scope? by Silverman, Richard M, Matava, Matthew J

“…Despite its widespread use and low complication rates, arthroscopic meniscectomy has not been uniformly successful in all patients, especially in those with…”
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Interaction of Candida albicans Cell Wall Als3 Protein with Streptococcus gordonii SspB Adhesin Promotes Development of Mixed-Species Communities by Silverman, Richard J, Nobbs, Angela H, Vickerman, M. Margaret, Barbour, Michele E, Jenkinson, Howard F

“…Candida albicans colonizes human mucosa and prosthetic surfaces associated with artificial joints, catheters, and dentures. In the oral cavity, C. albicans…”
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