Search Results - "Silverman, Jill"

Animal models for psychiatric research: Novel directions for behavioral neuroscience in translation by Silverman, Jill L.

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Behavioural phenotyping assays for mouse models of autism by Crawley, Jacqueline N, Silverman, Jill L, Yang, Mu, Lord, Catherine

“…Key Points Autism is a neurodevelopmental disorder that is diagnosed by the presence of three categories of behavioural criteria: first, unusual reciprocal…”
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Behavioral and neuroanatomical approaches in models of neurodevelopmental disorders: opportunities for translation by Silverman, Jill L, Ellegood, Jacob

“…This review highlights the invaluable contribution of in-vivo rodent models in dissecting the underlying neurobiology for numerous neurodevelopmental…”
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Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders by Ku, Katherine M, Weir, Ruth K, Silverman, Jill L, Berman, Robert F, Bauman, Melissa D

“…The laboratory rat is emerging as an attractive preclinical animal model of autism spectrum disorder (ASD), allowing investigators to explore genetic,…”
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Repetitive Self-Grooming Behavior in the BTBR Mouse Model of Autism is Blocked by the mGluR5 Antagonist MPEP by SILVERMAN, Jill L, TOLU, Seda S, BARMAN, Charlotte L, CRAWLEY, Jacqueline N

“…Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social interactions, communication deficits, and repetitive behaviors with…”
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Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication by Bozdagi, Ozlem, Sakurai, Takeshi, Papapetrou, Danae, Wang, Xiaobin, Dickstein, Dara L, Takahashi, Nagahide, Kajiwara, Yuji, Yang, Mu, Katz, Adam M, Scattoni, Maria Luisa, Harris, Mark J, Saxena, Roheeni, Silverman, Jill L, Crawley, Jacqueline N, Zhou, Qiang, Hof, Patrick R, Buxbaum, Joseph D

“…SHANK3 is a protein in the core of the postsynaptic density (PSD) and has a critical role in recruiting many key functional elements to the PSD and to the…”
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Autism-relevant social abnormalities and cognitive deficits in engrailed-2 knockout mice by Brielmaier, Jennifer, Matteson, Paul G, Silverman, Jill L, Senerth, Julia M, Kelly, Samantha, Genestine, Matthieu, Millonig, James H, DiCicco-Bloom, Emanuel, Crawley, Jacqueline N

“…ENGRAILED 2 (En2), a homeobox transcription factor, functions as a patterning gene in the early development and connectivity of rodent hindbrain and…”
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The Effects of Chronic Exposure to Ambient Traffic-Related Air Pollution on Alzheimer's Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats by Patten, Kelley T, Valenzuela, Anthony E, Wallis, Christopher, Berg, Elizabeth L, Silverman, Jill L, Bein, Keith J, Wexler, Anthony S, Lein, Pamela J

“…Epidemiological data link traffic-related air pollution (TRAP) to increased risk of Alzheimer's disease (AD). Preclinical data corroborating this association…”
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Germline Chd8 haploinsufficiency alters brain development in mouse by Gompers, Andrea L, Su-Feher, Linda, Ellegood, Jacob, Copping, Nycole A, Riyadh, M Asrafuzzaman, Stradleigh, Tyler W, Pride, Michael C, Schaffler, Melanie D, Wade, A Ayanna, Catta-Preta, Rinaldo, Zdilar, Iva, Louis, Shreya, Kaushik, Gaurav, Mannion, Brandon J, Plajzer-Frick, Ingrid, Afzal, Veena, Visel, Axel, Pennacchio, Len A, Dickel, Diane E, Lerch, Jason P, Crawley, Jacqueline N, Zarbalis, Konstantinos S, Silverman, Jill L, Nord, Alex S

“…Strong genetic evidence points to a significant role for heterozygous mutations to general chromatin remodeling factors, such as CHD8, in autism. Gompers et al…”
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Automated three-chambered social approach task for mice by Yang, Mu, Silverman, Jill L, Crawley, Jacqueline N

“…Autism is diagnosed by three major symptom categories: unusual reciprocal social interactions, impaired communication, and repetitive behaviors with restricted…”
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Modeling fragile X syndrome in the Fmr1 knockout mouse by Kazdoba, Tatiana M., Leach, Prescott T., Silverman, Jill L., Crawley, Jacqueline N.

“…Fragile X Syndrome (FXS) is a commonly inherited form of intellectual disability and one of the leading genetic causes for autism spectrum disorder. Clinical…”
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Quantitative measures of motor development in Angelman syndrome by Duis, Jessica, Skinner, Austin, Carson, Robert, Gouelle, Arnaud, Annoussamy, Melanie, Silverman, Jill L., Apkon, Susan, Servais, Laurent, Carollo, James

“…Angelman Syndrome is a rare neurodevelopmental disorder characterized by developmental delay, lack of speech, seizures, intellectual disability, characteristic…”
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Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication by Guignet, Michelle, Dhakal, Kiran, Flannery, Brenna M., Hobson, Brad A., Zolkowska, Dorota, Dhir, Ashish, Bruun, Donald A., Li, Shuyang, Wahab, Abdul, Harvey, Danielle J., Silverman, Jill L., Rogawski, Michael A., Lein, Pamela J.

“…Current medical countermeasures for organophosphate (OP)-induced status epilepticus (SE) are not effective in preventing long-term morbidity and there is an…”
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Reconsidering animal models used to study autism spectrum disorder: Current state and optimizing future by Silverman, Jill L., Thurm, Audrey, Ethridge, Sarah B., Soller, Makayla M., Petkova, Stela P., Abel, Ted, Bauman, Melissa D., Brodkin, Edward S., Harony‐Nicolas, Hala, Wöhr, Markus, Halladay, Alycia

“…Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and intellectual disability (ID), are pervasive, often lifelong disorders,…”
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Autism-specific maternal autoantibodies produce behavioral abnormalities in an endogenous antigen-driven mouse model of autism by Jones, Karen L., Pride, Michael C., Edmiston, Elizabeth, Yang, Mu, Silverman, Jill L., Crawley, Jacqueline N., Van de Water, Judy

“…Immune dysregulation has been noted consistently in individuals with autism spectrum disorder (ASD) and their families, including the presence of…”
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Emerging Gene and Small Molecule Therapies for the Neurodevelopmental Disorder Angelman Syndrome by Copping, Nycole A., McTighe, Stephanie M., Fink, Kyle D., Silverman, Jill L.

“…Angelman syndrome (AS) is a rare (~1:15,000) neurodevelopmental disorder characterized by severe developmental delay and intellectual disability, impaired…”
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Sociability and motor functions in Shank1 mutant mice by Silverman, Jill L, Turner, Sarah M, Barkan, Charlotte L, Tolu, Seda S, Saxena, Roheeni, Hung, Albert Y, Sheng, Morgan, Crawley, Jacqueline N

“…Abstract Autism is a neurodevelopmental disorder characterized by aberrant reciprocal social interactions, impaired communication, and repetitive behaviors…”
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Impact of School Closures, Precipitated by COVID-19, on Weight and Weight-Related Risk Factors among Schoolteachers: A Cross-Sectional Study by Silverman, Jill R, Wang, Branden Z

“…The school closures, precipitated by the COVID-19 pandemic, required teachers to convert their entire classroom curricula to online formats, taught from home…”
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Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice by Yang, Mu, Bozdagi, Ozlem, Scattoni, Maria Luisa, Wöhr, Markus, Roullet, Florence I, Katz, Adam M, Abrams, Danielle N, Kalikhman, David, Simon, Harrison, Woldeyohannes, Leuk, Zhang, James Y, Harris, Mark J, Saxena, Roheeni, Silverman, Jill L, Buxbaum, Joseph D, Crawley, Jacqueline N

“…Mutations in the synaptic scaffolding protein gene SHANK3 are strongly implicated in autism and Phelan-McDermid 22q13 deletion syndrome. The precise location…”
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Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism by Silverman, Jill L, Smith, Daniel G, Rizzo, Stacey J Sukoff, Karras, Michael N, Turner, Sarah M, Tolu, Seda S, Bryce, Dianne K, Smith, Deborah L, Fonseca, Kari, Ring, Robert H, Crawley, Jacqueline N

“…Neurodevelopmental disorders such as autism and fragile X syndrome were long thought to be medically untreatable, on the assumption that brain dysfunctions…”
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