Determination of phenolic and triterpenic compounds in Jatropha gossypiifolia L by Ultra-high performance liquid chromatography-tandem mass spectrometric (UHPLC-MS/MS)

This work describes the chemical characterization of extracts of Jatropha gossypiifolia (from Amazonia region) concerning the presence of phenolic and triterpenic compounds using Ultra High Perfomance Liquid chromatography coupled to Mass Spectrometry in Tandem (UHPLC-MS/MS) methods. The studied com...

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Bibliographic Details
Published in:	Brazilian Journal of Pharmaceutical Sciences Vol. 56
Main Authors:	Silveira, Rudinei da Silva, Leal, Gabriela Camera, Molin, Thais Ramos Dal, Faccin, Henrique, Gobo, Luciana Assis, Silveira, Géssica Domingos da, Souza, Mariana Tatsch da Silva, Lameira, Osmar Alves, Carvalho, Leandro Machado de, Viana, Carine
Format:	Journal Article
Language:	English
Published:	Sao Paulo Universidade de Sao Paulo Faculdade de Ciencias 01-01-2020 Universidade de São Paulo, Faculdade de Ciências Farmacêuticas Universidade de São Paulo
Subjects:	Acids Alternative medicine Antihypertensives Chromatography Herbal medicine Jatropha gossypiifolia L PHARMACOLOGY & PHARMACY Phenolic compounds Public health Triterpenic compounds UHPLC-MS/MS Brazil St Louis Missouri United States > US Germany UHPLC-MS/MS Phenolic compounds Jatropha gossypiifolia L Triterpenic compounds
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Summary:	This work describes the chemical characterization of extracts of Jatropha gossypiifolia (from Amazonia region) concerning the presence of phenolic and triterpenic compounds using Ultra High Perfomance Liquid chromatography coupled to Mass Spectrometry in Tandem (UHPLC-MS/MS) methods. The studied compounds belong to the most frequently found classes in medicinal plants (triterpenes, flavonoids, flavones, hydroxycinnamic acids, coumarins, catechins and stilbenes), which have been analyzed as chemical and bioactive markers in hydroethanolic and aqueous extracts. Several polyphenolic compounds identified herein are unprecedented in the scientific literature for this species. The chemical markers identified and quantified in the studied extracts of J. gossypiifolia were gallic acid, chlorogenic acid, catechin, caffeic acid, vanillic acid, p-coumaric acid, ferullic acid, rutin, quercitrin, 3-acetylcoumarin, trans-cinnamic acid, quercetin, luteolin, apigenin, kaempferol, chrysin. α-amyrin, β-amyrin and lupeol. As the majority compounds, (+)-catechin, p-coumaric acid, ferulic acid, luteolin, α-amyrin and β-amyrin were found to be present at mg kg-1 levels. J. gossypiifolia extracts presented a high in vitro activity against different reactive oxygen species (hydroxyl, peroxyl, and superoxide anion radicals). Several polyphenolic compound data presented herein are unprecedented in the scientific literature for this plant species. As a result, this plant can be a new source of bioactive molecules for therapeutic purposes.
ISSN:	2175-9790 1984-8250 2175-9790
DOI:	10.1590/s2175-97902019000417262