Search Results - "Silveira, Pablo A"

CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential by Li, Ziduo, Ju, Xinsheng, Silveira, Pablo A, Abadir, Edward, Hsu, Wei-Hsun, Hart, Derek N J, Clark, Georgina J

“…CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety…”
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A Subset of Interleukin-21 + Chemokine Receptor CCR9 + T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity by McGuire, Helen M., Vogelzang, Alexis, Ma, Cindy S., Hughes, William E., Silveira, Pablo A., Tangye, Stuart G., Christ, Daniel, Fulcher, David, Falcone, Marika, King, Cecile

“…This study describes a CD4 + T helper (Th) cell subset marked by coexpression of the cytokine interleukin 21 (IL-21) and the gut-homing chemokine receptor…”
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Anti-Mouse CD83 Monoclonal Antibody Targeting Mature Dendritic Cells Provides Protection Against Collagen Induced Arthritis by Silveira, Pablo A, Kupresanin, Fiona, Romano, Adelina, Hsu, Wei-Hsun, Lo, Tsun-Ho, Ju, Xinsheng, Chen, Hsiao-Ting, Roberts, Helen, Baker, Daniel G, Clark, Georgina J

“…Antibodies targeting the activation marker CD83 can achieve immune suppression by targeting antigen-presenting mature dendritic cells (DC). This study…”
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Dihydrotestosterone (DHT) Enhances Wound Healing of Major Burn Injury by Accelerating Resolution of Inflammation in Mice by Shi, Huaikai, Lo, Tsun-Ho, Ma, Duncan, Condor, Brenton, Lesmana, Brian, Parungao, Roxanne J, Tsai, Kevin H-Y, Kim, Sarah, Chen, Hsiao-Ting, Silveira, Pablo A, Li, Zhe, Cooper, Mark S, Simanainen, Ulla, Handelsman, David J, Maitz, Peter K, Wang, Yiwei

“…Androgens have been known to inhibit cutaneous wound healing in men and male mice. However, in children with major burn injuries, a synthetic androgen was…”
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CD83 is a new potential biomarker and therapeutic target for Hodgkin lymphoma by Li, Ziduo, Ju, Xinsheng, Lee, Kenneth, Clarke, Candice, Hsu, Jennifer L, Abadir, Edward, Bryant, Christian E, Pears, Suzanne, Sunderland, Neroli, Heffernan, Scott, Hennessy, Annemarie, Lo, Tsun-Ho, Pietersz, Geoffrey A, Kupresanin, Fiona, Fromm, Phillip D, Silveira, Pablo A, Tsonis, Con, Cooper, Wendy A, Cunningham, Ilona, Brown, Christina, Clark, Georgina J, Hart, Derek N J

“…Chemotherapy and hematopoietic stem cell transplantation are effective treatments for most Hodgkin lymphoma patients, however there remains a need for better…”
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Examination of CD302 as a potential therapeutic target for acute myeloid leukemia by Lo, Tsun-Ho, Abadir, Edward, Gasiorowski, Robin E, Kabani, Karieshma, Ramesh, Murari, Orellana, Daniel, Fromm, Phillip D, Kupresanin, Fiona, Newman, Elizabeth, Cunningham, Ilona, Hart, Derek N J, Silveira, Pablo A, Clark, Georgina J

“…Acute myeloid leukemia (AML) is the most common form of adult acute leukemia with ~20,000 new cases yearly. The disease develops in people of all ages, but is…”
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On the Other Side: Manipulating the Immune Checkpoint Landscape of Dendritic Cells to Enhance Cancer Immunotherapy by Kong, Benjamin Y, Bolton, Holly, Kim, Julius W, Silveira, Pablo A, Fromm, Phillip D, Clark, Georgina J

“…Monoclonal antibodies targeting co-inhibitory immune checkpoint molecules have been successful in clinical trials of both solid and hematological malignancies…”
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CD300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation by Abadir, Edward, Gasiorowski, Robin E., Lai, Kaitao, Kupresanin, Fiona, Romano, Adelina, Silveira, Pablo A., Lo, Tsun‐Ho, Fromm, Phillip D., Kennerson, Marina L., Iland, Harry J., Ho, P. Joy, Hogarth, P. Mark, Bradstock, Kenneth, Hart, Derek N.J., Clark, Georgina J.

“…Antibody‐based therapy in acute myeloid leukemia (AML) has been marred by significant hematologic toxicity due to targeting of both hematopoietic stem and…”
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The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self‐antigen‐specific immunoglobulin receptors by Silveira, Pablo A., Johnson, Ellis, Chapman, Harold D., Bui, Thi, Tisch, Roland M., Serreze, David V.

“…B lymphocytes partially contribute to autoimmune type 1 diabetes (T1D) as a subset of APC with a preferential ability to trigger pathogenic CD4 T cells. We…”
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Targeting CD300f to enhance hematopoietic stem cell transplantation in acute myeloid leukemia by Abadir, Edward, Silveira, Pablo A., Gasiorowski, Robin E., Ramesh, Murari, Romano, Adelina, Mekkawy, Ahmed H., Lo, Tsun-Ho, Kabani, Karieshma, Sutherland, Sarah, Pietersz, Geoffrey A., Ho, P. Joy, Bryant, Christian E., Larsen, Stephen R., Clark, Georgina J.

“…Allogeneic hematopoietic stem cell transplantation (allo-HSCT) significantly reduces the rate of relapse in acute myeloid leukemia (AML) but comes at the cost…”
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Targeting CD83 in mantle cell lymphoma with anti‐human CD83 antibody by Li, Ziduo, Abadir, Edward, Lee, Kenneth, Clarke, Candice, Bryant, Christian E, Cooper, Wendy, Pietersz, Geoffrey, Favaloro, James, Silveira, Pablo A, NJ Hart, Derek, Ju, Xinsheng, Clark, Georgina J

“…Objectives Effective antibody–drug conjugates (ADCs) provide potent targeted cancer therapies. CD83 is expressed on activated immune cells including B cells…”
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The cell surface phenotype of human dendritic cells by Clark, Georgina J., Silveira, Pablo A., Hogarth, P. Mark, Hart, Derek N.J.

“…Dendritic cells (DC) are bone marrow derived leucocytes that are part of the mononuclear phagocytic system. These are surveillance cells found in all tissues…”
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B-cell tolerance: mechanisms and implications by Basten, Antony, Silveira, Pablo A

“…Advances in our knowledge of the spectrum of B-cell activities combined with the remarkable clinical efficacy of B-cell inhibitors in autoimmunity and…”
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B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling by Mackay, Fabienne, Silveira, Pablo A, Brink, Robert

“…B-cell activation factor from the tumor necrosis factor family (BAFF) is a key survival factor during B-cell maturation — a delicate immune checkpoint for B…”
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Tropoelastin modulates systemic and local tissue responses to enhance wound healing by Wang, Ziyu, Shi, Huaikai, Silveira, Pablo A., Mithieux, Suzanne M., Wong, Wai Cheng, Liu, Linyang, Pham, Nguyen T.H., Hawkett, Brian S., Wang, Yiwei, Weiss, Anthony S.

“…Wound healing is facilitated by biomaterials-based grafts and substantially impacted by orchestrated inflammatory responses that are essential to the normal…”
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CD300f signalling induces inhibitory human monocytes/macrophages by Sutherland, Sarah I.M., Ju, Xinsheng, Silveira, Pablo A., Kupresanin, Fiona, Horvath, Lisa G., Clark, Georgina J.

“…•CD300f signalling on human monocytes/macrophages increases PD-L1 expression.•CD300f activates Akt/PI3K on human monocytes.•CD300f induces immune suppressive…”
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Cellular Expression Requirements for Inhibition of Type 1 Diabetes by a Dominantly Protective Major Histocompatibility Complex Haplotype by CHEN, Yi-Guang, SILVEIRA, Pablo A, OSBORNE, Melissa A, CHAPMAN, Harold D, SERREZE, David V

“…Cellular Expression Requirements for Inhibition of Type 1 Diabetes by a Dominantly Protective Major Histocompatibility Complex Haplotype Yi-Guang Chen 1 ,…”
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B cell-directed therapies in type 1 diabetes by Mariño, Eliana, Silveira, Pablo A, Stolp, Jessica, Grey, Shane T

“…B cells play a pathogenic role as antigen-presenting cells and autoantibody secretors in the lead up to T cell-mediated autoimmune destruction of…”
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Invasion of the killer B's in type 1 diabetes by Silveira, Pablo A, Serreze, David V, Grey, Shane T

“…Type 1 Diabetes (T1D) is an autoimmune disease requiring contributions from effectors in both CD4+ and CD8+ T cell compartments in order to destroy insulin…”
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The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population by Ju, Xinsheng, Silveira, Pablo A, Hsu, Wei-Hsun, Elgundi, Zehra, Alingcastre, Renz, Verma, Nirupama D, Fromm, Phillip D, Hsu, Jennifer L, Bryant, Christian, Li, Ziduo, Kupresanin, Fiona, Lo, Tsun-Ho, Clarke, Candice, Lee, Kenneth, McGuire, Helen, Fazekas de St Groth, Barbara, Larsen, Stephen R, Gibson, John, Bradstock, Kenneth F, Clark, Georgina J, Hart, Derek N J

“…CD83 is a member of the Ig gene superfamily, first identified in activated lymphocytes. Since then, CD83 has become an important marker for defining activated…”
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