Search Results - "Silveira, Linda Earnest"

HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research models by Torresi, Joseph, Tran, Bang Manh, Christiansen, Dale, Earnest-Silveira, Linda, Schwab, Renate Hilda Marianne, Vincan, Elizabeth

“…Hepatitis B virus (HBV) is the leading cause of liver cancer, but the mechanisms by which HBV causes liver cancer are poorly understood and chemotherapeutic…”
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A Hepatitis C Virus DNA Vaccine Encoding a Secreted, Oligomerized Form of Envelope Proteins Is Highly Immunogenic and Elicits Neutralizing Antibodies in Vaccinated Mice by Masavuli, Makutiro Ghislain, Wijesundara, Danushka K, Underwood, Alexander, Christiansen, Dale, Earnest-Silveira, Linda, Bull, Rowena, Torresi, Joseph, Gowans, Eric J, Grubor-Bauk, Branka

“…Hepatitis C virus (HCV) persistently infects approximately 71 million people globally. To prevent infection a vaccine which elicits neutralizing antibodies…”
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Modulation of MAPK pathways and cell cycle by replicating hepatitis B virus: Factors contributing to hepatocarcinogenesis by Chin, Ruth, Earnest-Silveira, Linda, Koeberlein, Bernd, Franz, Susanne, Zentgraf, Hanswalter, Dong, Xuebin, Gowans, Eric, Bock, C.-Thomas, Torresi, Joseph

“…Background/Aims Chronic infection with the hepatitis B virus (HBV) is strongly associated with the development of hepatocellular carcinoma but the mechanism by…”
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Hepatitis C VLPs delivered to dendritic cells by a TLR2 targeting lipopeptide results in enhanced antibody and cell-mediated responses by Chua, Brendon Y, Johnson, Douglas, Tan, Amabel, Earnest-Silveira, Linda, Sekiya, Toshiki, Chin, Ruth, Torresi, Joseph, Jackson, David C

“…Although many studies provide strong evidence supporting the development of HCV virus-like particle (VLP)-based vaccines, the fact that heterologous viral…”
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A self‐adjuvanting multiepitope immunogen that induces a broadly cross‐reactive antibody to hepatitis C virus by Torresi, Joseph, Stock, Owen M., Fischer, Alexandra E., Grollo, Lara, Drummer, Heidi, Boo, Irene, Zeng, Weiguang, Earnest‐Silveira, Linda, Jackson, David C.

“…We describe a peptide‐based strategy for HCV vaccine design that addresses the problem of variability in hypervariable region 1 (HVR1). Peptides representing…”
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Probing and pressing surfaces of hepatitis C virus-like particles by Collett, Simon, Torresi, Joseph, Earnest-Silveira, Linda, Christiansen, Dale, Elbourne, Aaron, Ramsland, Paul A.

“…[Display omitted] Hepatitis C virus-like particles (VLPs) are being developed as a quadrivalent vaccine candidate, eliciting both humoral and cellular immune…”
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Investigating virus–host cell interactions: Comparative binding forces between hepatitis C virus-like particles and host cell receptors in 2D and 3D cell culture models by Collett, Simon, Torresi, Joseph, Silveira, Linda Earnest, Truong, Vi Khanh, Christiansen, Dale, Tran, Bang M., Vincan, Elizabeth, Ramsland, Paul A., Elbourne, Aaron

“…[Display omitted] Cell cultures have been successfully used to study hepatitis C virus (HCV) for many years. However, most work has been done using…”
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Hepatitis C virus-induced hepatocyte cell death and protection by inhibition of apoptosis by Lim, Eu Jin, El Khobar, Korri, Chin, Ruth, Earnest-Silveira, Linda, Angus, Peter W, Bock, C-Thomas, Nachbur, Ueli, Silke, John, Torresi, Joseph

“…Chronic hepatitis C virus (HCV) infection results in progressive liver fibrosis leading to cirrhosis and liver cancer. The mechanism for this remains unclear…”
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Antibody Responses to a Quadrivalent Hepatitis C Viral-Like Particle Vaccine Adjuvanted with Toll-Like Receptor 2 Agonists by Christiansen, Dale, Earnest-Silveira, Linda, Chua, Brendon, Boo, Irene, Drummer, Heidi E, Grubor-Bauk, Branka, Gowans, Eric J, Jackson, David C, Torresi, Joseph

“…The development of an effective preventative hepatitis C virus (HCV) vaccine will reside, in part, in its ability to elicit neutralizing antibodies (NAbs). We…”
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Reduced Antigenicity of the Hepatitis B Virus HBsAg Protein Arising as a Consequence of Sequence Changes in the Overlapping Polymerase Gene That Are Selected by Lamivudine Therapy by Torresi, Joseph, Earnest-Silveira, Linda, Deliyannis, Georgia, Edgtton, Kristy, Zhuang, Hui, Locarnini, Stephen A, Fyfe, Janet, Sozzi, Tina, Jackson, David C

“…The prevalence of hepatitis B virus vaccine escape mutants has increased as a consequence of the introduction of global vaccination programs. Furthermore and…”
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Restoration of Replication Phenotype of Lamivudine-Resistant Hepatitis B Virus Mutants by Compensatory Changes in the “Fingers” Subdomain of the Viral Polymerase Selected as a Consequence of Mutations in the Overlapping S Gene by Torresi, Joseph, Earnest-Silveira, Linda, Civitico, Gilda, Walters, Tomos E., Lewin, Sharon R., Fyfe, Janet, Locarnini, Stephen A., Manns, Michael, Trautwein, Christian, Bock, Thomas C.

“…The introduction of lamivudine (LMV) for the treatment of chronic hepatitis B infection has been an important advance in the management of this disease…”
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Dysregulation of hepatocyte cell cycle and cell viability by hepatitis B virus by Chin, Ruth, Nachbur, Ulrich, Earnest-Silveira, Linda, Bankovacki, Aleksandra, Koeberlein, Bernd, Zentgraf, Hanswalter, Bock, C.-Thomas, Silke, John, Torresi, Joseph

“…Dysregulation of the cell cycle is frequently associated with tumor development. Hepatitis B virus (HBV) is associated with a significant risk of developing…”
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Fiber-modified recombinant adenoviral constructs encoding hepatitis C virus proteins induce potent HCV-specific T cell response by Thammanichanond, Duangtawan, Moneer, Sarah, Yotnda, Patricia, Aitken, Campbell, Earnest-Silveira, Linda, Jackson, David, Hellard, Margaret, McCluskey, James, Torresi, Joseph, Bharadwaj, Mandvi

“…Abstract Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes (CTLs) play an important role in HCV clearance. The frequency of HCV-specific TCD8 in…”
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Failure of lamivudine to reverse hepatitis B virus-associated changes in ERK, Akt and cell cycle regulatory proteins by CHIN, Ruth, EARNEST-SILVEIRA, Linda, KOEBERLEIN, Bernd, FRANZ, Susanne, ZENTGRAF, Hanswalter, BOWDEN, Scott, BOCK, C-Thomas, TORRESI, Joseph

“…Chronic infection with hepatitis B virus (HBV) is a major factor associated with the development of hepatocellular carcinoma, but the mechanism by which this…”
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Severe hepatitis and prolonged hepatitis B virus-specific CD8 T-cell response after selection of hepatitis B virus YMDD variant in an HIV/hepatitis B virus-co-infected patient by GOUSKOS, Theo, WIGHTMAN, Fiona, CHANGE, Judy, EARNEST-SILVEIRA, Linda, SASADEUSZ, Joseph, LEWIN, Sharon R, TORRESI, Joseph

“…We describe here a severe flare of hepatitis caused by lamivudine-resistant hepatitis B virus(HBV) in an HIV/HBV co-infected individual.Lamivudine-resistant…”
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