Search Results - "Silveira, Leonardo R"

Exercise therapy normalizes BDNF upregulation and glial hyperactivity in a mouse model of neuropathic pain by Almeida, Cayo, DeMaman, Aline, Kusuda, Ricardo, Cadetti, Flaviane, Ravanelli, Maria Ida, Queiroz, André L., Sousa, Thais A., Zanon, Sonia, Silveira, Leonardo R., Lucas, Guilherme

“…Treatment of neuropathic pain is a clinical challenge likely because of the time-dependent changes in many neurotransmitter systems, growth factors, ionic…”
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Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function by Martins, Amanda R, Nachbar, Renato T, Gorjao, Renata, Vinolo, Marco A, Festuccia, William T, Lambertucci, Rafael H, Cury-Boaventura, Maria F, Silveira, Leonardo R, Curi, Rui, Hirabara, Sandro M

“…Insulin resistance condition is associated to the development of several syndromes, such as obesity, type 2 diabetes mellitus and metabolic syndrome. Although…”
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Melatonin prevents mitochondrial dysfunction and insulin resistance in rat skeletal muscle by Teodoro, Bruno G., Baraldi, Flavia G., Sampaio, Igor H., Bomfim, Lucas H. M., Queiroz, André L., Passos, Madla A., Carneiro, Everardo M., Alberici, Luciane C., Gomis, Ramon, Amaral, Fernanda G., Cipolla-Neto, José, Araújo, Michel B., Lima, Tanes, Akira Uyemura, Sérgio, Silveira, Leonardo R., Vieira, Elaine

“…Melatonin has a number of beneficial metabolic actions and reduced levels of melatonin may contribute to type 2 diabetes. The present study investigated the…”
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ARHGAP21 as a master regulator of multiple cellular processes by Rosa, Lucas R. O., Soares, Gabriela M., Silveira, Leonardo R., Boschero, Antonio C., Barbosa‐Sampaio, Helena C. L.

“…The cellular cytoskeleton is involved with multiple biological processes and is tightly regulated by multiple proteins and effectors. Among these, the…”
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Role of NCoR1 in mitochondrial function and energy metabolism by Lima, Tanes I., Valentim, Rafael R., Araújo, Hygor N., Oliveira, André G., Favero, Bianca C., Menezes, Eveline S., Araújo, Rafaela, Silveira, Leonardo R.

“…Mitochondrial number and shape are constantly changing in response to increased energy demands. The ability to synchronize mitochondrial pathways to respond to…”
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Concerted regulation of skeletal muscle metabolism and contractile properties by the orphan nuclear receptor Nr2f6 by Guimarães, Dimitrius Santiago P. S. F., Barrios, Ninon M. F., Oliveira, André Gustavo, Rizo‐Roca, David, Jollet, Maxence, Smith, Jonathon A.B., Araujo, Thiago R., Cruz, Marcos Vinicius, Marconato, Emilio, Hirabara, Sandro M., Vieira, André S., Krook, Anna, Zierath, Juleen R., Silveira, Leonardo R.

“…Background The maintenance of skeletal muscle plasticity upon changes in the environment, nutrient supply, and exercise depends on regulatory mechanisms that…”
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The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1α inhibition by Queiroz, André L., Lessard, Sarah J., Ouchida, Amanda T., Araujo, Hygor N., Gonçalves, Dawit A., Simões Fróes Guimarães, Dimitrius Santiago P., Teodoro, Bruno G., So, Kawai, Espreafico, Enilza M., Hirshman, Michael F., Alberici, Luciane C., Kettelhut, Isis do Carmo, Goodyear, Laurie J., Silveira, Leonardo R.

“…MicroRNAs (miRNA) are known to regulate the expression of genes involved in several physiological processes including metabolism, mitochondrial biogenesis,…”
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In Vivo Electrical Stimulation for the Assessment of Skeletal Muscle Contractile Function in Murine Models by Vitzel, Kaio F, Fortes, Marco A, Marzuca-Nassr, Gabriel Nasri, Scervino, Maria V M, Pinheiro, Carlos H, Silveira, Leonardo R, Curi, Rui

“…Skeletal muscle electrical stimulation is commonly used for clinical purposes, assisting recovery, preservation, or even improvement of muscle mass and…”
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Updating the effects of fatty acids on skeletal muscle by Silveira, Leonardo R., Fiamoncini, Jarlei, Hirabara, Sandro M., Procópio, Joaquim, Cambiaghi, Tavane D., Pinheiro, Carlos Hermano J., Lopes, Lúcia R., Curi, Rui

“…In this review we updated the fatty acid (FA) effects on skeletal muscle metabolism. Abnormal FA availability induces insulin resistance and accounts for…”
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Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity by Bassit, Reinaldo Abunasser, Pinheiro, Carlos Hermano da Justa, Vitzel, Kaio Fernando, Sproesser, Antônio José, Silveira, Leonardo R., Curi, Rui

“…The protective effect of short-term creatine supplementation (CrS) upon markers of strenuous contractile activity-induced damage in human and rat skeletal…”
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Abnormal brown adipose tissue mitochondrial structure and function in IL10 deficiency by de-Lima-Júnior, José C., Souza, Gabriela F., Moura-Assis, Alexandre, Gaspar, Rodrigo S., Gaspar, Joana M., Rocha, Andréa L., Ferrucci, Danilo L., Lima, Tanes I., Victório, Sheila C., Bonfante, Ivan L.P., Cavaglieri, Claudia R., Pareja, José C., Brunetto, Sérgio Q., Ramos, Celso D., Geloneze, Bruno, Mori, Marcelo A., Silveira, Leonardo R., Segundo, Gesmar R.S., Ropelle, Eduardo R., Velloso, Lício A.

“…Inflammation is the most relevant mechanism linking obesity with insulin-resistance and metabolic disease. It impacts the structure and function of tissues and…”
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Endurance training inhibits insulin clearance and IDE expression in Swiss mice by Costa-Júnior, José M, Ferreira, Sandra M, Protzek, André O, Santos, Gustavo J, Cappelli, Ana P, Silveira, Leonardo R, Zoppi, Cláudio, de Oliveira, Camila A M, Boschero, Antonio C, Carneiro, Everardo M, Rezende, Luiz F

“…Endurance training improves peripheral insulin sensitivity in the liver and the skeletal muscle, but the mechanism for this effect is poorly understood…”
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Transcriptional profile in rat muscle: down-regulation networks in acute strenuous exercise by Felipe, Stela Mirla da Silva, de Freitas, Raquel Martins, Penha, Emanuel Diego Dos Santos, Pacheco, Christina, Martins, Danilo Lopes, Alves, Juliana Osório, Soares, Paula Matias, Loureiro, Adriano César Carneiro, Lima, Tanes, Silveira, Leonardo R, Ferraz, Alex Soares Marreiros, de Souza, Jorge Estefano Santana, Leal-Cardoso, Jose Henrique, Carvalho, Denise P, Ceccatto, Vania Marilande

“…Physical exercise is a health promotion factor regulating gene expression and causing changes in phenotype, varying according to exercise type and intensity…”
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Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway by Filiputti, Eliane, Rafacho, Alex, Araújo, Eliana P, Silveira, Leonardo R, Trevisan, Amon, Batista, Thiago M, Curi, Rui, Velloso, Lício A, Quesada, Ivan, Boschero, Antonio C, Carneiro, Everardo M

“…Abstract A regimen of low-protein diet induces a reduction of pancreatic islet function that is associated with development of metabolic disorders including…”
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Involvement of eukaryotic translation initiation factor 5A (eIF5A) in skeletal muscle stem cell differentiation by Luchessi, Augusto D., Cambiaghi, Tavane D., Hirabara, Sandro M., Lambertucci, Rafael H., Silveira, Leonardo R., Baptista, Igor L., Moriscot, Anselmo S., Costa-Neto, Claudio M., Curi, Rui

“…The eukaryotic translation initiation factor 5A (eIF5A) contains a special amino acid residue named hypusine that is required for its activity, being produced…”
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Insulin release, peripheral insulin resistance and muscle function in protein malnutrition: a role of tricarboxylic acid cycle anaplerosis by Zoppi, Claudio C, Silveira, Leonardo R, Oliveira, Camila A. M, Boschero, Antonio C, Curi, Rui, Carneiro, Everardo M

“…Pancreatic β-cells and skeletal muscle act in a synergic way in the control of systemic glucose homeostasis. Several pyruvate-dependent and -independent…”
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Exercise training enhances rat pancreatic islets anaplerotic enzymes content despite reduced insulin secretion by Zoppi, Claudio C., Calegari, Vivian C., Silveira, Leonardo R., Carneiro, Everardo M., Boschero, Antonio C.

“…Endurance exercise has been shown to reduce pancreatic islets glucose-stimulated insulin secretion (GSIS). Anaplerotic/cataplerotic pathways are directly…”
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Essential role of the PGC‐1α/PPARβ axis in Ucp3 gene induction by Lima, Tanes I., Guimarães, Dimitrius, Sponton, Carlos H., Bajgelman, Marcio C., Palameta, Soledad, Toscaro, Jessica M., Reis, Osvaldo, Silveira, Leonardo R.

“…Key points We report that the peroxisome proliferator‐activated receptor (PPAR)γ coactivator 1‐α (PGC‐1α)/PPARβ axis is a crucial mediator of uncoupling…”
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HSP72 as a complementary protection against oxidative stress induced by exercise in the soleus muscle of rats by Smolka, M B, Zoppi, C C, Alves, A A, Silveira, L R, Marangoni, S, Pereira-Da-Silva, L, Novello, J C, Macedo, D V

“…Given the potential of reactive oxygen species to damage intracellular proteins during subsequent bouts of muscle contractions, it was suggested that, when…”
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Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging by Lima, Tanes I, Laurila, Pirkka-Pekka, Wohlwend, Martin, Morel, Jean David, Goeminne, Ludger J E, Li, Hao, Romani, Mario, Li, Xiaoxu, Oh, Chang-Myung, Park, Dohyun, Rodríguez-López, Sandra, Ivanisevic, Julijana, Gallart-Ayala, Hector, Crisol, Barbara, Delort, Florence, Batonnet-Pichon, Sabrina, Silveira, Leonardo R, Sankabattula Pavani Veera Venkata, Lakshmi, Padala, Anil K, Jain, Suresh, Auwerx, Johan

“…Disruption of mitochondrial function and protein homeostasis plays a central role in aging. However, how these processes interact and what governs their…”
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