Search Results - "Silvander, Camilla"

Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design by Rahm, Fredrik, Viklund, Jenny, Trésaugues, Lionel, Ellermann, Manuel, Giese, Anja, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Günther, Judith, Hallberg, Kenth, Lindström, Johan, Persson, Lars Boukharta, Silvander, Camilla, Talagas, Antoine, Díaz-Sáez, Laura, Fedorov, Oleg, Huber, Kilian V. M, Panagakou, Ioanna, Siejka, Paulina, Gorjánácz, Mátyás, Bauser, Marcus, Andersson, Martin

“…Recent literature has both suggested and questioned MTH1 as a novel cancer target. BAY-707 was just published as a target validation small molecule probe for…”
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Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases by Trésaugues, Lionel, Silvander, Camilla, Flodin, Susanne, Welin, Martin, Nyman, Tomas, Gräslund, Susanne, Hammarström, Martin, Berglund, Helena, Nordlund, Pär

“…SHIP2, OCRL, and INPP5B belong to inositol polyphosphate 5-phophatase subfamilies involved in insulin regulation and Lowes syndrome. The structural basis for…”
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Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target by Ellermann, Manuel, Eheim, Ashley, Rahm, Fredrik, Viklund, Jenny, Guenther, Judith, Andersson, Martin, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Lindström, Johan, Silvander, Camilla, Trésaugues, Lionel, Giese, Anja, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Bauser, Marcus, Haegebarth, Andrea, Gorjánácz, Mátyás

“…MTH1 is a hydrolase responsible for sanitization of oxidized purine nucleoside triphosphates to prevent their incorporation into replicating DNA. Early tool…”
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Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate by Trésaugues, Lionel, Lundbäck, Thomas, Welin, Martin, Flodin, Susanne, Nyman, Tomas, Silvander, Camilla, Gräslund, Susanne, Nordlund, Pär

“…Human NUDT16 is a member of the NUDIX hydrolase superfamily. After having been initially described as an mRNA decapping enzyme, recent studies conferred it a…”
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Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti‐tumor efficacy by Yu, Yasmin, Bogdan, Madhumita, Noman, Muhammad Zaeem, Parpal, Santiago, Bartolini, Elisabetta, Van Moer, Kris, Kleinendorst, Simone Caroline, Bilgrav Saether, Kristine, Trésaugues, Lionel, Silvander, Camilla, Lindström, Johan, Simeon, Jodi, Timson, Mary Jane, Al‐Hashimi, Hikmat, Smith, Bryan D., Flynn, Daniel L., Alexeyenko, Andrey, Viklund, Jenny, Andersson, Martin, Martinsson, Jessica, Pokrovskaja Tamm, Katja, De Milito, Angelo, Janji, Bassam

“…An immunosuppressive tumor microenvironment promotes tumor growth and is one of the main factors limiting the response to cancer immunotherapy. We have…”
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Abstract 689: Identification and optimization of novel chemical matter via a structure-based approach resulting in a probe for MTH1 by Bauser, Marcus, Giese, Anja, Ellermann, Manuel, Guenther, Judith, Eheim, Ashley, Bunse, Stefanie, Neuhaus, Roland, Weiske, Joerg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Haegebarth, Andrea, Gorjanacz, Matyas, Tresaugues, Lionel, Ginman, Tobias, Rahm, Fredrik, Andersson, Martin, Ericsson, Ulrica, Forsblom, Rickard, Lindstroem, Johan, Silvander, Camilla, Vicklund, Jenny

“…Abstract Cancer cells can form reactive oxygen species (ROS) due to altered redox regulation that affect desoxynucleosides triphosphates (dNTP) in particular…”
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Crystal Structures of Type-II Inositol Polyphosphate 5‑Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5‑Phosphatase Family by Mills, Stephen J, Silvander, Camilla, Cozier, Gyles, Trésaugues, Lionel, Nordlund, Pär, Potter, Barry V. L

“…The inositol polyphosphate 5-phosphatase INPP5B hydrolyzes the 5-phosphate group from water- and lipid-soluble signaling messengers. Two synthetic benzene and…”
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