Search Results - "Silva‐Lima, Beatriz"

Anti‐inflammatory Effect of Rosmarinic Acid and an Extract of Rosmarinus officinalis in Rat Models of Local and Systemic Inflammation by Rocha, Joao, Eduardo‐Figueira, Maria, Barateiro, Andreia, Fernandes, Adelaide, Brites, Dora, Bronze, Rosario, Duarte, Catarina MM, Serra, Ana Teresa, Pinto, Rui, Freitas, Marisa, Fernandes, Eduarda, Silva‐Lima, Beatriz, Mota‐Filipe, Helder, Sepodes, Bruno

“…Rosmarinic acid is a polyphenolic compound and main constituent of Rosmarinus officinalis and has been shown to possess antioxidant and anti‐inflammatory…”
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Identification of Marker Compounds and In Vitro Toxicity Evaluation of Two Portuguese Asphodelus Leaf Extracts by Malmir, Maryam, Lima, Katelene, Póvoas Camões, Sérgio, Manageiro, Vera, Duarte, Maria Paula, Paiva Miranda, Joana, Serrano, Rita, Moreira da Silva, Isabel, Silva Lima, Beatriz, Caniça, Manuela, Silva, Olga

“…The leaves of subsp. , an endemic Portuguese species, and subsp. have been used as food, and traditionally as medicine, for treating ulcers, urinary tract, and…”
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Next-generation nanomedicines and nanosimilars: EU regulators' initiatives relating to the development and evaluation of nanomedicines by Ehmann, Falk, Sakai-Kato, Kumiko, Duncan, Ruth, Hernán Pérez de la Ossa, Dolores, Pita, Ruben, Vidal, Jean-Marc, Kohli, Ashish, Tothfalusi, Laszlo, Sanh, Alan, Tinton, Sandrine, Robert, Jean-Louis, Silva Lima, Beatriz, Amati, Marisa Papaluca

“…Over the last three decades many first-generation nanomedicines have successfully entered routine clinical use and it is now important for medicines regulatory…”
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Stem cell–derived models to improve mechanistic understanding and prediction of human drug‐induced liver injury by Goldring, Christopher, Antoine, Daniel J., Bonner, Frank, Crozier, Jonathan, Denning, Chris, Fontana, Robert J., Hanley, Neil A., Hay, David C., Ingelman‐Sundberg, Magnus, Juhila, Satu, Kitteringham, Neil, Silva‐Lima, Beatriz, Norris, Alan, Pridgeon, Chris, Ross, James A., Young, Rowena Sison, Tagle, Danilo, Tornesi, Belen, van de Water, Bob, Weaver, Richard J., Zhang, Fang, Park, B. Kevin

“…Current preclinical drug testing does not predict some forms of adverse drug reactions in humans. Efforts at improving predictability of drug‐induced tissue…”
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Toxicology and Biodistribution: The Clinical Value of Animal Biodistribution Studies by Silva Lima, Beatriz, Videira, Mafalda Ascensão

“…Since the human genome decoding, understanding and identification of genetic disturbances behind many diseases, including cancer, are intensively increasing…”
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Monographic Quality Parameters and Genotoxicity Assessment of Asphodelus bento-rainhae and Asphodelus macrocarpus Root Tubers as Herbal Medicines by Malmir, Maryam, Serrano, Rita, Lima, Katelene, Duarte, Maria Paula, Moreira da Silva, Isabel, Silva Lima, Beatriz, Caniça, Manuela, Silva, Olga

“…Root tubers of subsp. (AbR), an endemic species with relevant interest due to conservation concerns, and subsp. (AmR) have been traditionally used for culinary…”
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Oral supplementation with fish oil reduces dryness and pruritus in the acetone-induced dry skin rat model by Barcelos, Raquel C.S, de Mello-Sampayo, Cristina, Antoniazzi, Caren T.D, Segat, Hecson J, Silva, Henrique, Veit, Juliana C, Piccolo, Jaqueline, Emanuelli, Tatiana, Bürger, Marilise E, Silva- Lima, Beatriz, Rodrigues, Luis M

“…Highlights • Fish oil supplementation improves skin n -6/ n -3 ratio. • Skin barrier dynamics seem to be positively influenced by skin n -6/ n -3 ratio…”
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Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop by Buesen, Roland, Chorley, Brian N., da Silva Lima, Beatriz, Daston, George, Deferme, Lize, Ebbels, Timothy, Gant, Timothy W., Goetz, Amber, Greally, John, Gribaldo, Laura, Hackermüller, Jörg, Hubesch, Bruno, Jennen, Danyel, Johnson, Kamin, Kanno, Jun, Kauffmann, Hans-Martin, Laffont, Madeleine, McMullen, Patrick, Meehan, Richard, Pemberton, Mark, Perdichizzi, Stefania, Piersma, Aldert H., Sauer, Ursula G., Schmidt, Kerstin, Seitz, Hervé, Sumida, Kayo, Tollefsen, Knut E., Tong, Weida, Tralau, Tewes, van Ravenzwaay, Ben, Weber, Ralf J.M., Worth, Andrew, Yauk, Carole, Poole, Alan

“…Prevailing knowledge gaps in linking specific molecular changes to apical outcomes and methodological uncertainties in the generation, storage, processing, and…”
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Regulatory acceptance of animal models of disease to support clinical trials of medicines and advanced therapy medicinal products by Cavagnaro, Joy, Silva Lima, Beatriz

“…The utility of animal models of disease for assessing the safety of novel therapeutic modalities has become an increasingly important topic of discussion as…”
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Ineffective health management in hemodialysis patients: content analysis by Paiva, Maria das Graças Mariano Nunes de, Tinôco, Jéssica Dantas de Sá, Silva, Fernanda Beatriz Batista Lima E, Dantas, Juliane Rangel, Lopes, Marcos Venícios de Oliveira, Lira, Ana Luisa Brandão de Carvalho

“…To analyze the content of the nursing diagnosis Ineffective Health Management in hemodialysis patients. The Nursing Diagnoses Validation Model by Lopes, Silva…”
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Critical analysis of carcinogenicity study outcomes. Relationship with pharmacological properties by van der Laan, Jan Willem, Kasper, Peter, Silva Lima, Beatriz, Jones, David R., Pasanen, Markku

“…Predicting the outcome of life-time carcinogenicity studies in rats based on chronic (6-month) toxicity studies in this species is possible in some instances…”
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Challenges with advanced therapy medicinal products and how to meet them by Schneider, Christian K, Salmikangas, Paula, Jilma, Bernd, Flamion, Bruno, Todorova, Lyubina Racheva, Paphitou, Anna, Haunerova, Ivana, Maimets, Toivo, Trouvin, Jean-Hugues, Flory, Egbert, Tsiftsoglou, Asterios, Sarkadi, Balázs, Gudmundsson, Kolbeinn, O'Donovan, Maura, Migliaccio, Giovanni, Ancāns, Jānis, Maciulaitis, Romaldas, Robert, Jean-Louis, Samuel, Anthony, Ovelgönne, Johannes H, Hystad, Marit, Fal, Andrzej Mariusz, Lima, Beatriz Silva, Moraru, Anca Stela, Turcáni, Peter, Zorec, Robert, Ruiz, Sol, Akerblom, Lennart, Narayanan, Gopalan, Kent, Alastair, Bignami, Fabrizia, Dickson, J George, Niederwieser, Dietger, Figuerola-Santos, María-Angeles, Reischl, Ilona G, Beuneu, Claire, Georgiev, Rosen, Vassiliou, Maria, Pychova, Alena, Clausen, Mette, Methuen, Taina, Lucas, Sophie, Schüssler-Lenz, Martina, Kokkas, Vasilios, Buzás, Zsuzsanna, MacAleenan, Niall, Galli, Maria Cristina, Linē, Aija, Gulbinovic, Jolanta, Berchem, Guy, Fraczek, Mariusz, Menezes-Ferreira, Margarida, Vilceanu, Nela, Hrubisko, Mikulás, Marinko, Petra, Timón, Marcos, Cheng, Wing, Crosbie, George Andrew, Meade, Nick, di Paola, Michelino Lipucci, VandenDriessche, Thierry, Ljungman, Per, D'Apote, Lucia, Oliver-Diaz, Olga, Büttel, Isabel, Celis, Patrick

“…Advanced therapy medicinal products (ATMPs) offer hope for the treatment of diseases for which therapeutic options are currently lacking. This article…”
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Bioguided Identification of Active Antimicrobial Compounds from Asphodelus bento-rainhae and Asphodelus macrocarpus Root Tubers by Malmir, Maryam, Lima, Katelene, Camões, Sérgio Póvoas, Manageiro, Vera, Duarte, Maria Paula, Miranda, Joana Paiva, Serrano, Rita, da Silva, Isabel Moreira, Lima, Beatriz Silva, Caniça, Manuela, Silva, Olga

“…Root tubers of subsp. (AbR), a vulnerable endemic species, and subsp. (AmR) have traditionally been used in Portugal to treat inflammatory and infectious skin…”
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Non-biological Complex Drugs (NBCDs): Complex Pharmaceuticals in Need of Individual Robust Clinical Assessment Before Any Therapeutic Equivalence Decision by Gaspar, Rogério Sá, Silva-Lima, Beatriz, Magro, Fernando, Alcobia, Armando, da Costa, Fernando Leal, Feio, José

“…Non-Biological Complex Drugs (NBCDs) are complex non-biological drugs comprised of large high molecular weight molecules and, often, nanoparticular structures…”
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A Comprehensive Review on the Medicinal Plants from the Genus Asphodelus by Malmir, Maryam, Serrano, Rita, Caniça, Manuela, Silva-Lima, Beatriz, Silva, Olga

“…Plant-based systems continue to play an essential role in healthcare, and their use by different cultures has been extensively documented. L. ( ) is a genus of…”
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Scientific Advances in Diabetes: The Impact of the Innovative Medicines Initiative by Brito, Maria de Fátima, Torre, Carla, Silva-Lima, Beatriz

“…Diabetes Mellitus is one of the World Health Organization's priority diseases under research by the first and second programmes of Innovative Medicines…”
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The European and American Use of Exploratory Approaches for First-in-Human Studies by Silva-Lima, Beatriz, Carlson, David, Jones, David R., Laurie, David, Stahl, Elke, Maria, Vasco, Janssens, Walter, Robinson, William T.

“…Exploratory approaches for first‐in‐human clinical studies have evolved over the last few years and have stimulated the issuance of national regulatory…”
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An Integrated Approach to the Anti-Inflammatory, Antioxidant, and Genotoxic Potential of Portuguese Traditional Preparations from the Bark of Anacardium occidentale L by Encarnação, Sofia, Lima, Katelene, Malú, Quintino, Caldeira, Gonçalo I, Duarte, Maria Paula, Rocha, João, Lima, Beatriz Silva, Silva, Olga

“…L. stem bark Traditional Herbal Preparations (AoBTHPs) are widely used in traditional medicine to treat inflammatory conditions, such as diabetes. The present…”
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Evaluation of Marine Microalga Diacronema vlkianum Biomass Fatty Acid Assimilation in Wistar Rats by de Mello-Sampayo, Cristina, Paterna, Angela, Polizzi, Ambra, Duarte, Diana, Batista, Irineu, Pinto, Rui, Gonçalves, Patrícia, Raymundo, Anabela, Batista, Ana P, Gouveia, Luísa, Silva-Lima, Beatriz, Bandarra, Narcisa M

“…is a marine microalgae for which supposed health promoting effects have been claimed based on its phytochemical composition. The potential use of its biomass…”
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Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorindeia juglandifolia Leaves by Malú, Quintino, Lima, Katelene, Malmir, Maryam, Pinto, Rui, da Silva, Isabel Moreira, Catarino, Luís, Duarte, Maria Paula, Serrano, Rita, Rocha, João, Lima, Beatriz Silva, Silva, Olga

“…Dried leaves of A. Rich. and (A. Rich.) Planch. ex Oliv. (family Anacardiaceae) are used in African traditional medicine. Although these medicinal plants have…”
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