Search Results - "Silva, Victor Diogenes A."

Role of Microgliosis and NLRP3 Inflammasome in Parkinson’s Disease Pathogenesis and Therapy by de Araújo, Fillipe M., Cuenca-Bermejo, Lorena, Fernández-Villalba, Emiliano, Costa, Silvia L., Silva, Victor Diogenes A., Herrero, Maria Trinidad

“…Parkinson's disease (PD) is a neurodegenerative disorder marked primarily by motor symptoms such as rigidity, bradykinesia, postural instability and resting…”
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The Flavonoid Agathisflavone Directs Brain Microglia/Macrophages to a Neuroprotective Anti-Inflammatory and Antioxidant State via Regulation of NLRP3 Inflammasome by Dos Santos, Balbino Lino, Dos Santos, Cleonice Creusa, Soares, Janaina R P, da Silva, Karina C, de Oliveira, Juciele Valeria R, Pereira, Gabriele S, de Araújo, Fillipe M, Costa, Maria de Fátima D, David, Jorge Mauricio, da Silva, Victor Diogenes A, Butt, Arthur Morgan, Costa, Silvia Lima

“…Agathisflavone, purified from (Tul.) has been shown to be neuroprotective in in vitro models of glutamate-induced excitotoxicity and inflammatory damage…”
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Assessment of neurotoxicity of monocrotaline, an alkaloid extracted from Crotalaria retusa in astrocyte/neuron co-culture system by Pitanga, Bruno P.S., Silva, Victor Diógenes A., Souza, Cleide S., Junqueira, Huiara A., Fragomeni, Breno O.N., Nascimento, Ravena P., Silva, Ana Rita, Costa, Maria de Fátima D., El-Bachá, Ramon S., Costa, Silvia L.

“…► Alkaloid monocrotalina (MCT) from Crotalaria retusa, is cytotoxic to cortical neurons and astrocytes. ► Neuron/glial cell in co-cultures MCT changes the…”
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Three New Polyprenylated Benzophenone Derivatives Isolated from Clusia burle-marxii by C Silva, Maria do Carmo, V Carvalho, Fernanda, G Ferreira, Antonio, Venâncio, Tiago, G F da Silva, Maria Fátima, A Silva, Victor Diogenes, L Costa, Silvia, G Ferraz, Caline G, Ribeiro, Paulo Roberto

“…Three new polyprenylated benzophenone derivatives named burlemarxione G-I (1-3) were isolated from C. burle-marxii trunks (compound 1) and leaves (compounds 2…”
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Combination of a multiplatform metabolite profiling approach and chemometrics as a powerful strategy to identify bioactive metabolites in Lepidium meyenii (Peruvian maca) by Carvalho, Fernanda V., Fonseca Santana, Lucia, Diogenes A. da Silva, Victor, Costa, Silvia L., Zambotti-Villelae, Leonardo, Colepicolo, Pio, Ferraz, Caline G., Ribeiro, Paulo R.

“…[Display omitted] •The chemical profile and bioactivity of L. meyenii extracts were assessed.•Seventy-five metabolites were identified in the extracts by…”
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Agathisflavone as a Single Therapy or in Association With Mesenchymal Stem Cells Improves Tissue Repair in a Spinal Cord Injury Model in Rats by do Nascimento, Ravena P, de Jesus, Lívia B, Oliveira-Junior, Markley S, Almeida, Aurea M, Moreira, Eduardo L T, Paredes, Bruno D, David, Jorge M, Souza, Bruno S F, de Fátima D Costa, Maria, Butt, Arthur M, Silva, Victor Diogenes A, Costa, Silvia L

“…Agathisflavone is a flavonoid with anti-neuroinflammatory and myelinogenic properties, being also capable to induce neurogenesis. This study evaluated the…”
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Involvement of astrocytic CYP1A1 isoform in the metabolism and toxicity of the alkaloid pyrrolizidine monocrotaline by Nascimento, Ravena P., Oliveira, Joana L., Carvalho, José Leilton C., Santos, William A., Pires, Thyago Rubens C., Batatinha, Maria José M., El-Bachá, Ramon S., Silva, Victor Diógenes A., Costa, Silvia L.

“…Monocrotaline (MCT) and its pyrrole derivative, dehydromonocrotaline (DHMC), interact with molecular targets in cells of the central nervous system. DHMC…”
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Identification of bioactive metabolites from corn silk extracts by a combination of metabolite profiling, univariate statistical analysis and chemometrics by da Hora, Natan R.S., Santana, Lucia F., da Silva, Victor Diogenes A., Costa, Silvia L., Zambotti-Villela, Leonardo, Colepicolo, Pio, Ferraz, Caline G., Ribeiro, Paulo R.

“…[Display omitted] •The composition and bioactivity of corn silk extracts were assessed.•Thirty-four metabolites were identified in the extracts by HPLC-MS and…”
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The Role of Astrocytes in Metabolism and Neurotoxicity of the Pyrrolizidine Alkaloid Monocrotaline, the Main Toxin of Crotalaria retusa by Pitanga, Bruno Penas Seara, Nascimento, Ravena P, Silva, Victor Diógenes A, Costa, Silvia L

“…The metabolic interactions and signaling between neurons and glial cells are necessary for the development and maintenance of brain functions and structures…”
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The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination by de Almeida, Monique Marylin Alves, Pieropan, Francesca, de Mattos Oliveira, Larissa, dos Santos Junior, Manoelito Coelho, David, Jorge Mauricio, David, Juceni Pereira, da Silva, Victor Diógenes A., dos Santos Souza, Cleide, Costa, Silvia Lima, Butt, Arthur Morgan

“…[Display omitted] •Agathisflavone enhances remyelination through modulating neuroinflammation.•Agathisflavone induces a polarization in microglia from an M1 to…”
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Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression by Santos, Balbino L., Oliveira, Mona N., Coelho, Paulo L.C., Pitanga, Bruno P.S., da Silva, Alessandra B., Adelita, Taís, Silva, Victor Diógenes A., Costa, Maria de F.D., El-Bachá, Ramon S., Tardy, Marcienne, Chneiweiss, Hervé, Junier, Marie-Pierre, Moura-Neto, Vivaldo, Costa, Silvia L.

“…The malignant gliomas are very common primary brain tumors with poor prognosis, which require more effective therapies than the current used, such as with…”
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Aminochrome induces microglia and astrocyte activation by Santos, Cleonice C., Araújo, Fillipe M., Ferreira, Rafael S., Silva, Vanessa B., Silva, Juliana H.C., Grangeiro, Maria S., Soares, Érica N., Pereira, Érica Patricia L., Souza, Cleide S., Costa, Silvia L., Segura-Aguilar, Juan, Silva, Victor Diogenes A.

“…Aminochrome has been suggested as a more physiological preclinical model capable of inducing five of the six mechanisms of Parkinson's Disease (PD). Until now,…”
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Monocrotaline induces acutely cerebrovascular lesions, astrogliosis and neuronal degeneration associated with behavior changes in rats: A model of vascular damage in perspective by Silva, Adriana L., Oliveira, Joana L., do Nascimento, Ravena P., Santos, Letícia O., de Araújo, Fillipe M., dos Santos, Balbino L., Santana, Rejane C., Moreira, Eduardo Luiz T., Batatinha, Maria José M., Alves, Iura M., Velozo, Eudes S., Victor, Mauricio M., Assis, Adriano M., Almeida, Roberto F., de Souza, Diogo O.G., Silva, Victor Diógenes A., Costa, Silvia L.

“…Pyrrolizidine alkaloids (PAs) are secondary plant metabolites playing an important role as phytotoxins in the plant defense mechanisms and can be present as…”
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Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures by de Araújo, Fillipe M., Ferreira, Rafael S., Souza, Cleide S., dos Santos, Cleonice Creusa, Rodrigues, Tácio L.R.S., e Silva, Juliana Helena C., Gasparotto, Juciano, Gelain, Daniel Pens, El-Bachá, Ramon S., D. Costa, Maria de Fátima, Fonseca, José Claudio M., Segura-Aguilar, Juan, Costa, Silvia L., Silva, Victor Diogenes A.

“…•Aminochrome induces toxicity in midbrain slice cultures.•Aminochrome induces neuroinflammation in midbrain slice cultures.•Aminochrome reduces NGF and GDNF…”
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Juliprosopine and Juliprosine from Prosopis juliflora Leaves Induce Mitochondrial Damage and Cytoplasmic Vacuolation on Cocultured Glial Cells and Neurons by Silva, Victor Diogenes A, Pitanga, Bruno P. S, Nascimento, Ravena P, Souza, Cleide S, Coelho, Paulo Lucas C, Menezes-Filho, Noélio, Silva, André Mário M, Costa, Maria de Fátima D, El-Bachá, Ramon S, Velozo, Eudes S, Costa, Silvia L

“…Prosopis juliflora is a shrub largely used for animal and human consumption. However, ingestion has been shown to induce intoxication in animals, which is…”
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Saponin-rich fraction from Agave sisalana: effect against malignant astrocytic cells and its chemical characterisation by ESI-MS/MS by de Oliveira, João Victor A., Botura, Mariana B., dos Santos, Jener D. G., Argolo, Deivison S., da Silva, Victor Diogenes A., da Silva, Gisele D., de Lima, Hélimar G., Braz Filho, Raimundo, Vieira, Ivo Jose C., Branco, Alexsandro, Batatinha, Maria José M., Costa, Silvia L.

“…Astrocytic tumour cells derived from human (GL-15) and rat (C6) gliomas, as well as non-tumoural astrocytic cells, were exposed to the saponin-rich fraction…”
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Flavonoids Modulate the Proliferation of Neospora caninum in Glial Cell Primary Cultures by Matos, Rosan Barbosa De, Braga-de-Souza, Suzana, Pitanga, Bruno Pena Seara, Silva, Victor Diogenes Amaral Da, Jesus, Erica Etelvina Viana De, Pinheiro, Alexandre Morales, Costa, Maria De Fatima Dias, El-Bacha, Ramon Dos Santos, Ribeiro, Catia Suse De Oliveira, Costa, Silvia Lima

“…Neospora caninum (Apicomplexa; Sarcocystidae) is a protozoan that causes abortion in cattle, horses, sheep, and dogs as well as neurological and dermatological…”
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