Role of Adenosine on Intestinal Ischemia-Reperfusion Injury in Rabbits

Abstract To study if the treatment with adenosine (ADO), an agonist of adenosine receptors, attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), we treated rabbits with ADO (15 mg · kg−1 , intravenously) or saline solution (SS) to I (60 minutes) before occlusion of superior...

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Published in:	Transplantation proceedings Vol. 42; no. 2; pp. 454 - 456
Main Authors:	Taha, M.O, Miranda-Ferreira, R, Simões, R.S, Abrão, M.S, Oliveira-Junior, I.S, Monteiro, H.P, Santos, J.M, Rodrigues, P.H, Rodrigues, J.V, Alves, A.E.M, Nascimento, E.C, Silva, T.L.B, Zeviani, W.M, Caricati-Neto, A
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Amsterdam Elsevier Inc 01-03-2010 Elsevier
Subjects:	Adenosine - pharmacology Animals Biological and medical sciences Blood Circulation Electric Stimulation Femoral Vein - drug effects Femoral Vein - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Gastroenterology. Liver. Pancreas. Abdomen Intestines - blood supply Jejunum - blood supply Jejunum - drug effects Jejunum - physiology Male Medical sciences Mesenteric Artery, Superior - physiology Muscle Contraction - drug effects Muscle Contraction - physiology Other diseases. Semiology Potassium Chloride - pharmacology Purinergic P1 Receptor Agonists Rabbits Reperfusion Injury - drug therapy Sodium Chloride - pharmacology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology Purine nucleoside Temperature Adenosine Cold Rabbit Environmental factor Transplantation Lagomorpha Medicine Vertebrata Mammalia Reperfusion Treatment Surgery Animal Intestinal ischemia Digestive diseases Intestinal disease Graft
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Summary:	Abstract To study if the treatment with adenosine (ADO), an agonist of adenosine receptors, attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), we treated rabbits with ADO (15 mg · kg−1 , intravenously) or saline solution (SS) to I (60 minutes) before occlusion of superior mesenteric artery and/or R (120 min). After I or I/R, isolated jejunal segments (2 cm) were mounted in an organ bath to study nerve-mediated contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained (hematoxylin and eosin) for analysis by optical microscopy. Compared to the sham group, the jejunal contractions were similar in I + ADO, but reduced in I + SS, I/R + SS, and I/R + ADO groups. We concluded that the jejunal enteric nerves were damaged in I + SS, I/R + SS, and I/R + ADO, but not in I + ADO group. These results suggested that ADO attenuated intestinal dysfunction due to I, but not to R.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0041-1345 1873-2623
DOI:	10.1016/j.transproceed.2010.01.019