Remission in Crohn’s disease is accompanied by alterations in the gut microbiota and mucins production

Previous studies have demonstrated that patients with Crohn’s disease (CD) in remission do not exhibit an improvement in gut microbiota composition, which might trigger relapses. The present study investigated the dysbiosis and mucins production in CD patients during remission. We performed an analy...

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Bibliographic Details
Published in:	Scientific reports Vol. 9; no. 1; pp. 13263 - 10
Main Authors:	Magro, Daniéla Oliveira, Santos, Andrey, Guadagnini, Dioze, de Godoy, Flavia Moreira, Silva, Sylvia Helena Monteiro, Lemos, Wilson José Fernandes, Vitulo, Nicola, Torriani, Sandra, Pinheiro, Lilian Vital, Martinez, Carlos Augusto Real, Saad, Mario José Abdalla, Coy, Claudio Saddy Rodrigues
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13-09-2019 Nature Publishing Group
Subjects:	692/4020/1503/257/1402 692/4020/1503/2745 Adult Bacteria Bacteria - classification Bacteria - genetics Bacteria - isolation & purification Case-Control Studies Crohn Disease - microbiology Crohn Disease - therapy Cross-Sectional Studies Dysbacteriosis Dysbiosis - prevention & control Environmental factors Female Gastrointestinal Microbiome Humanities and Social Sciences Humans Intestinal microflora Male Microbiota Middle Aged Mucin Mucins Mucins - metabolism multidisciplinary Remission Remission Induction Saccharomyces cerevisiae Science Science (multidisciplinary) Sulfate reduction Sulfate-reducing bacteria Yeast Yeasts Young Adult
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Summary:	Previous studies have demonstrated that patients with Crohn’s disease (CD) in remission do not exhibit an improvement in gut microbiota composition, which might trigger relapses. The present study investigated the dysbiosis and mucins production in CD patients during remission. We performed an analytical cross-sectional single center study, which recruited 18 CD patients and 18 healthy controls (CG) residing in the same home, meaning that all of the participants experienced the same environmental factors, with similar hygiene status, diet, pollution and other common lifestyle characteristics that may influence the composition of the gut microbiota. When compared to healthy controls, the CD patients exhibited lower microbial α-diversity (p = 0.047), a greater abundance of the Proteobacteria phylum (p = 0.037) and a reduction in the Deltaproteobacteria class (p = 0.0006). There was also a reduction in the Akkermansia (p = 0.002) and Oscillospira (p = 0.024) genera and in the proportion of the yeast Saccharomyces cerevisiae (p = 0.01). Additionally, CD patients in remission presented increased neutral (p = 0.001) and acid mucin (p = 0.002) concentrations. The reductions in the proportions of Oscollospira and Akkermansia genera, sulfate-reducing bacteria and Saccharomyces cerevisiae , observed in the CD group, may account for the increased mucins production observed in these patients.
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-019-49893-5