Search Results - "Silva, Sara Duarte"

Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts by Esteves, Sofia, Silva, Sara Carina Duarte, Maciel, P.

“…Polyglutamine (PolyQ) diseases are a group of neurodegenerative disorders caused by the expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats in…”
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Neuroprotective effects of creatine in the CMVMJD135 mouse model of Spinocerebellar Ataxia type 3 by Silva, Sara Carina Duarte, Carvalho, Andreia Alexandra Neves, Cunha, Carina Isabel Soares, Silva, Joana M., Castro, Andreia Cristiana Teixeira, Vieira, Rita, Fernandes, Anabela Silva, Maciel, P.

“…Background and Objective: Mitochondrial dysfunction has been implicated in several neurodegenerative diseases. Creatine administration increases concentration…”
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IP3R2 null mice display a normal acquisition of somatic and neurological development milestones by Guerra‐Gomes, Sónia, Cunha‐Garcia, Daniela, Marques Nascimento, Diana Sofia, Duarte‐Silva, Sara, Loureiro‐Campos, Eduardo, Morais Sardinha, Vanessa, Viana, João Filipe, Sousa, Nuno, Maciel, Patrícia, Pinto, Luísa, Oliveira, João Filipe

“…Astrocytes are key players in the regulation of brain development and function. They sense and respond to the surrounding activity by elevating their…”
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Unilateral intrastriatal 6-hydroxydopamine lesion in mice: a closer look into non-motor phenotype and glial response by Pinheiro, Bárbara Filipa Mendes, Cunha, Carina Isabel Soares, Marote, Ana Maria Franco Aveiro, Loureiro-Campos, Eduardo, Campos, Jonas Oliveira, Barata-Antunes, Sandra, Fernandes, Daniela Monteiro, Santos, Diogo Jorge Ferreira, Silva, Sara Carina Duarte, Pinto, Luísa, Salgado, A. J.

“…Parkinson’s disease (PD) is a prevalent movement disorder characterized by the progressive loss of dopaminergic neurons in substantia nigra pars compacta…”
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Absence of Tau triggers age-dependent sciatic nerve morphofunctional deficits and motor impairment by Lopes, Sofia Oliveira, Lopes, André Teixeira, Pinto, Vítor Manuel Silva, Guimarães, Marco Rafael, Sardinha, Vanessa Alexandra Morais, Silva, Sara Duarte, Pinheiro, Sara Isabel Santos, Pizarro, João Pedro Rodrigues, Oliveira, João F., Sousa, Nuno, Leite-Almeida, Hugo, Sotiropoulos, Ioannis

“…Dementia is the cardinal feature of Alzheimer's disease (AD), yet the clinical symptoms of this disorder also include a marked loss of motor function. Tau…”
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Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells by Neves-Carvalho, Andreia, Logarinho, Elsa, Freitas, Ana, Duarte-Silva, Sara, Costa, Maria do Carmo, Silva-Fernandes, Anabela, Martins, Margarida, Serra, Sofia Cravino, Lopes, André T, Paulson, Henry L, Heutink, Peter, Relvas, João B, Maciel, Patrícia

“…The physiological function of Ataxin-3 (ATXN3), a deubiquitylase (DUB) involved in Machado-Joseph Disease (MJD), remains elusive. In this study, we demonstrate…”
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Genetic ablation of inositol 1,4,5-Trisphosphate receptor type 2 (IP3R2) fails to modify disease progression in a mouse model of Spinocerebellar Ataxia type 3 by Garcia, Daniela Raquel Cunha, Fernandes, Daniela Monteiro, Correia, Joana Sofia, Carvalho, Andreia Alexandra Neves, Ferreira, Ana Catarina Coutinho Vilaça, Gomes, Sónia Isabel Nunes Guerra, Viana, João Filipe Oliveira, Oliveira, João F., Castro, Andreia Cristiana Teixeira, Maciel, P., Silva, Sara Carina Duarte

“…Spinocerebellar ataxia type 3 (SCA3) is a rare neurodegenerative disease caused by an abnormal polyglutamine expansion within the ataxin-3 protein (ATXN3)…”
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Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease by Esteves, Sofia, Duarte-Silva, Sara, Naia, Luana, Neves-Carvalho, Andreia, Teixeira-Castro, Andreia, Rego, Ana Cristina, Silva-Fernandes, Anabela, Maciel, Patrícia

“…Machado-Joseph disease (MJD) is an inherited neurodegenerative disease, caused by a CAG repeat expansion within the coding region of ATXN3 gene, and which…”
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Profiling microglia in a mouse model of Machado–Joseph disease by Campos, Ana Bela, Silva, Sara Duarte, Fernandes, Bruno, Neves, Sofia Pereira das, Marques, Fernanda, Castro, Andreia Teixeira, Carvalho, Andreia Neves, Fernandes, Daniela Monteiro, Portugal, Camila Cabral, Socodato, Renato, Summavielle, Teresa, Ambrósio, António Francisco, Relvas, João Bettencourt, Maciel, Patrícia

“…Microglia have been increasingly implicated in neurodegenerative diseases (NDs), and specific disease associated microglia (DAM) profiles have been defined for…”
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Intrathecal injection of the secretome from ALS motor neurons regulated for miR-124 expression prevents disease outcomes in SOD1-G93A mice by Barbosa, Marta, Santos, Marta, de Sousa, Nídia, Silva, Sara Carina Duarte, Vaz, Ana Rita, Salgado, A. J., Brites, Dora

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with short life expectancy and no effective therapy. We previously identified upregulated…”
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Microglial depletion has no impact on disease progression in a mouse model of machado–joseph disease by Campos, Ana Bela, Silva, Sara Carina Duarte, Fernandes, Bruno, Coimbra, Bárbara, Campos, Jonas, Monteiro-Fernandes, Daniela, Teixeira-Castro, Andreia, Ambrósio, António Francisco, Maciel, P.

“…Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is an autosomal dominant neurodegenerative disorder (ND). While most research…”
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Motor uncoordination and neuropathology in a transgenic mouse model of Machado–Joseph disease lacking intranuclear inclusions and ataxin-3 cleavage products by Silva-Fernandes, Anabela, Costa, Maria do Carmo, Duarte-Silva, Sara, Oliveira, Pedro, Botelho, Claudia M, Martins, Luís, Mariz, José António, Ferreira, Tiago, Ribeiro, Filipa, Correia-Neves, Margarida, Costa, Cristina, Maciel, Patrícia

“…Abstract Machado–Joseph disease (MJD) is a late-onset neurodegenerative disorder caused by a polyglutamine (polyQ) expansion in the ataxin-3 protein. We…”
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Preclinical assessment of mesenchymal-stem-cell-based therapies in spinocerebellar ataxia type 3 by Correia, Joana Sofia Silva, Carvalho, Andreia Alexandra Neves, Pinheiro, Bárbara Filipa Mendes, Pires, Joel Pereira, Teixeira, Fábio Gabriel Rodrigues, Lima, Rui Augusto Ribeiro, Monteiro, Susana Isabel Gonçalves, Silva, Nuno André Martins, Cunha, Carina Isabel Soares, Serra, Sofia Cravino, Silva, Sara Carina Duarte, Castro, Andreia Cristiana Teixeira, Salgado, A. J., Maciel, P.

“…The low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies for…”
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Cerebellar neuronal dysfunction accompanies early motor symptoms in spinocerebellar ataxia type 3 by Mayoral-Palarz, Kristin, Neves-Carvalho, Andreia, Duarte-Silva, Sara, Monteiro-Fernandes, Daniela, Maciel, Patrícia, Khodakhah, Kamran

“…Spinocerebellar Ataxia Type 3 (SCA3) is an adult-onset, progressive ataxia. SCA3 presents with ataxia before any gross neuropathology. A feature of many…”
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Chronic Treatment with 17-DMAG Improves Balance and Coordination in A New Mouse Model of Machado-Joseph Disease by Silva-Fernandes, Anabela, Duarte-Silva, Sara, Neves-Carvalho, Andreia, Amorim, Marina, Soares-Cunha, Carina, Oliveira, Pedro, Thirstrup, Kenneth, Teixeira-Castro, Andreia, Maciel, Patrícia

“…Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disease currently with no treatment. We describe a novel mouse…”
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Human platelet lysate supports SH‐SY5Y neuroblastoma cell proliferation and differentiation into a dopaminergic‐like neuronal phenotype under xenogeneic‐free culture conditions by Ribeiro, Miguel, Campos, Jonas, Pinho, Tiffany S., Sampaio‐Marques, Belém, Barata‐Antunes, Sandra, Cibrão, Jorge Ribeiro, Araújo, Ricardo, Duarte‐Silva, Sara, Moreira, Elsa, Sousa, Rui A., Costa, Pedro M., Salgado, António J.

“…SH‐SY5Y is a human neuroblastoma cell line that can be differentiated into several neuronal phenotypes, depending on culture conditions. For this reason, this…”
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Cell-based therapeutic strategies for treatment of spinocerebellar ataxias: an update by Correia, Joana, Duarte-Silva, Sara, Salgado, António, Maciel, Patrícia

“…Spinocerebellar ataxias are heritable neurodegenerative diseases caused by a cytosine-adenine-guanine expansion, which encodes a long glutamine tract…”
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Splenic sympathetic signaling contributes to acute neutrophil infiltration of the injured spinal cord by Monteiro, Susana, Pinho, Andreia G, Macieira, Mara, Serre-Miranda, Cláudia, Cibrão, Jorge R, Lima, Rui, Soares-Cunha, Carina, Vasconcelos, Natália L, Lentilhas-Graça, José, Duarte-Silva, Sara, Miranda, Alice, Correia-Neves, Margarida, Salgado, António J, Silva, Nuno A

“…Abstract Background Alterations in the immune system are a complication of spinal cord injury (SCI) and have been linked to an excessive sympathetic outflow to…”
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Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson's Disease by Rosa, Alexandra Isabel, Silva, Sara Carina Duarte, Silva-Fernandes, Anabela, Nunes, Maria João, Carvalho, Andreia Neves, Rodrigues, Elsa, Gama, Maria João, Rodrigues, Cecília Maria Pereira, Maciel, P., Castro-Caldas, Margarida

“…Parkinson's disease (PD) is characterized by severe motor symptoms, and currently there is no treatment that retards disease progression or reverses damage…”
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Mitochondrial Dysfunction and Decreased Cytochrome c in Cell and Animal Models of Machado–Joseph Disease by Almeida, Filipa, Ferreira, Ildete L., Naia, Luana, Marinho, Daniela, Vilaça-Ferreira, Ana Catarina, Costa, Marta D., Duarte-Silva, Sara, Maciel, Patrícia, Rego, A. Cristina

“…Mitochondrial dysfunction has been described in many neurodegenerative disorders; however, there is less information regarding mitochondrial deficits in…”
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