Search Results - "Silva, Rui FM"

Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro by Pogačnik, Lea, Pirc, Katja, Palmela, Inês, Skrt, Mihaela, Kwang, Kim S, Brites, Dora, Brito, Maria Alexandra, Ulrih, Nataša Poklar, Silva, Rui F.M

“…Abstract Natural food sources constitute a promising source of new compounds with neuroprotective properties, once they have the ability to reach the brain…”
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Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10 by Silva, Sandra L., Vaz, Ana R., Diógenes, Maria J., van Rooijen, Nico, Sebastião, Ana M., Fernandes, Adelaide, Silva, Rui F.M., Brites, Dora

“…Neuronal oxidative damage and cell death by unconjugated bilirubin (UCB) showed to be mediated by overstimulation of glutamate receptors and nitric oxide (NO)…”
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Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study by Palmela, Inês, Correia, Leonor, Silva, Rui F M, Sasaki, Hiroyuki, Kim, Kwang S, Brites, Dora, Brito, Maria A

“…Ursodeoxycholic acid and its main conjugate glycoursodeoxycholic acid are bile acids with neuroprotective properties. Our previous studies demonstrated their…”
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Features of bilirubin-induced reactive microglia: From phagocytosis to inflammation by Silva, Sandra L, Vaz, Ana R, Barateiro, Andreia, Falcão, Ana S, Fernandes, Adelaide, Brito, Maria A, Silva, Rui F.M, Brites, Dora

“…Abstract Microglia constitute the brain's immunocompetent cells and are intricately implicated in numerous inflammatory processes included in neonatal brain…”
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Cross-Talk Between Neurons and Astrocytes in Response to Bilirubin: Early Beneficial Effects by Falcão, Ana Sofia, Silva, Rui F. M., Vaz, Ana Rita, Silva, Sandra Leitão, Fernandes, Adelaide, Brites, Dora

“…Hyperbilirubinemia remains one of the most frequent clinical diagnoses in the neonatal period. This condition may lead to the deposition of unconjugated…”
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Axonal elongation and dendritic branching is enhanced by adenosine A sub(2A) receptors activation in cerebral cortical neurons by Ribeiro, Filipa F, Neves-Tome, Raquel, Assaife-Lopes, Natalia, Santos, Telma E, Silva, Rui FM, Brites, Dora, Ribeiro, Joaquim A, Sousa, Monica M, Sebastiao, Ana M

“…Axon growth and dendrite development are key processes for the establishment of a functional neuronal network. Adenosine, which is released by neurons and…”
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MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes by Fernandes, Adelaide, Falcão, Ana S., Silva, Rui F. M., Brito, Maria A., Brites, Dora

“…When activated by unconjugated bilirubin (UCB), astrocytes are important sources of inflammatory mediators such as TNF‐α, IL‐1β and IL‐6, which may contribute…”
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N-Methyl-d-Aspartate Receptor and Neuronal Nitric Oxide Synthase Activation Mediate Bilirubin-Induced Neurotoxicity by Brito, Maria A, Vaz, Ana R, Silva, Sandra L, Falcão, Ana S, Fernandes, Adelaide, Silva, Rui FM, Brites, Dora

“…Hyperbilirubinemia may lead to neurotoxicity and neuronal death. Although the mechanisms of nerve cell damage by unconjugated bilirubin (UCB) appear to involve…”
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Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin by Fernandes, Adelaide, Falcão, Ana S., Silva, Rui F. M., Gordo, Ana C., Gama, Maria J., Brito, Maria A., Brites, Dora

“…During neonatal hyperbilirubinaemia, astrocytes activated by unconjugated bilirubin (UCB) may contibute to brain toxicity through the production of cytokines…”
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Cross-Talk Between Neurons and Astrocytes in Response to Bilirubin: Adverse Secondary Impacts by Falcão, Ana Sofia, Silva, Rui F. M., Vaz, Ana Rita, Gomes, Cátia, Fernandes, Adelaide, Barateiro, Andreia, Tiribelli, Claudio, Brites, Dora

“…Previous studies using monotypic nerve cell cultures have shown that bilirubin-induced neurological dysfunction (BIND) involves apoptosis and necrosis-like…”
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Dynamics of neuronaglia interplay upon exposure to unconjugated bilirubin by Silva, Sandra L, OsA3rio, Catarina, Vaz, Ana R, Barateiro, Andreia, FalcALo, Ana S, Silva, Rui FM, Brites, Dora

“…Microglia are the main players of the brain immune response. They act as active sensors that rapidly respond to injurious insults by shifting into different…”
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