Search Results - "Silva, Rui F.M"

Features of bilirubin-induced reactive microglia: From phagocytosis to inflammation by Silva, Sandra L, Vaz, Ana R, Barateiro, Andreia, Falcão, Ana S, Fernandes, Adelaide, Brito, Maria A, Silva, Rui F.M, Brites, Dora

“…Abstract Microglia constitute the brain's immunocompetent cells and are intricately implicated in numerous inflammatory processes included in neonatal brain…”
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Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cells by Brito, Maria A, Rosa, Alexandra I, Falcão, Ana S, Fernandes, Adelaide, Silva, Rui F.M, Butterfield, D. Allan, Brites, Dora

“…Abstract We investigated whether nerve cell damage by unconjugated bilirubin (UCB) is mediated by oxidative stress and ascertained the neuronal and astroglial…”
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Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro by Pogačnik, Lea, Pirc, Katja, Palmela, Inês, Skrt, Mihaela, Kwang, Kim S, Brites, Dora, Brito, Maria Alexandra, Ulrih, Nataša Poklar, Silva, Rui F.M

“…Abstract Natural food sources constitute a promising source of new compounds with neuroprotective properties, once they have the ability to reach the brain…”
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Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation by Garcia, Gonçalo, Nanni, Sara, Figueira, Inês, Ivanov, Ines, McDougall, Gordon J., Stewart, Derek, Ferreira, Ricardo B., Pinto, Paula, Silva, Rui F.M., Brites, Dora, Santos, Cláudia N.

“…[Display omitted] •Raspberry digested metabolites protect neurons and microglia towards H2O2 and LPS insults.•Neuroprotection is independent of intracellular…”
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Poyphenols – between neuroprotection and neurotoxicity by POGAČNIK, Lea, SILVA, Rui F.M.

“…Polyphenols are a group of secondary metabolites found in a wide variety of foods, such as fruits, vegetables, wine, tea, olive oil and chocolate. These…”
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Food, polyphenols and neuroprotection by Silva, Rui F M, Pogačnik, Lea

“…Neuron loss and neurodegeneration are the common denom- inators of what are known as neurodegenerative diseases. Although the clinical manifestations of some…”
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Bilirubin toxicity to human erythrocytes: A review by Alexandra Brito, Maria, Silva, Rui F.M., Brites, Dora

“…Neonatal jaundice, a physiologic condition reflecting the interplay between developmentally modulated changes in bilirubin production and metabolism, affects…”
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Unconjugated bilirubin activates and damages microglia by Gordo, Ana C., Falcão, Ana S., Fernandes, Adelaide, Brito, Maria A., Silva, Rui F.M., Brites, Dora

“…Microglia are the resident immune cells of the brain and are the principal source of cytokines produced during central nervous system inflammation. We have…”
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Bilirubin-induced inflammatory response, glutamate release, and cell death in rat cortical astrocytes are enhanced in younger cells by Falcão, Ana S., Fernandes, Adelaide, Brito, Maria A., Silva, Rui F.M., Brites, Dora

“…Unconjugated bilirubin (UCB) encephalopathy is a predominantly early life condition resulting from the impairment of several cellular functions in the brain of…”
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Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS by Fernandes, Adelaide, Silva, Rui F.M, Falcão, Ana S, Brito, Maria A, Brites, Dora

“…In hyperbilirubinemic newborns, sepsis is considered a risk factor for kernicterus. Evidence shows that injury to astrocytes triggers cytokine release. We…”
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Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid by Silva, R F, Rodrigues, C M, Brites, D

“…Unconjugated bilirubin (UCB) can be neurotoxic in jaundiced neonates and in patients with Crigler-Najjar syndrome. UCB toxicity may culminate in cell death,…”
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Influence of hypoxia and ischemia preconditioning on bilirubin damage to astrocytes by Falcão, Ana S, Silva, Rui F.M, Fernandes, Adelaide, Brito, Maria A, Brites, Dora

“…Abstract Hypoxia–ischemia in the perinatal period is a common cause of neurologic disability in children and is often associated with neonatal morbidity and…”
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Polyphenols from Food and Natural Products: Neuroprotection and Safety by Silva, Rui F M, Pogačnik, Lea

“…Polyphenols are naturally occurring micronutrients that are present in many food sources. Besides being potent antioxidants, these molecules may also possess…”
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Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10 by Silva, Sandra L., Vaz, Ana R., Diógenes, Maria J., van Rooijen, Nico, Sebastião, Ana M., Fernandes, Adelaide, Silva, Rui F.M., Brites, Dora

“…Neuronal oxidative damage and cell death by unconjugated bilirubin (UCB) showed to be mediated by overstimulation of glutamate receptors and nitric oxide (NO)…”
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Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons by Ribeiro, Filipa F., Neves-Tomé, Raquel, Assaife-Lopes, Natália, Santos, Telma E., Silva, Rui F. M., Brites, Dora, Ribeiro, Joaquim A., Sousa, Mónica M., Sebastião, Ana M.

“…Axon growth and dendrite development are key processes for the establishment of a functional neuronal network. Adenosine, which is released by neurons and…”
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Neuroprotective Properties of Food-Borne Polyphenols in Neurodegenerative Diseases by Silva, Rui F. M., Pogačnik, Lea

“…Fruits and vegetables are the richest source of polyphenols in the regular human diet [...]…”
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Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study by Palmela, Inês, Correia, Leonor, Silva, Rui F M, Sasaki, Hiroyuki, Kim, Kwang S, Brites, Dora, Brito, Maria A

“…Ursodeoxycholic acid and its main conjugate glycoursodeoxycholic acid are bile acids with neuroprotective properties. Our previous studies demonstrated their…”
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Cross-Talk Between Neurons and Astrocytes in Response to Bilirubin: Early Beneficial Effects by Falcão, Ana Sofia, Silva, Rui F. M., Vaz, Ana Rita, Silva, Sandra Leitão, Fernandes, Adelaide, Brites, Dora

“…Hyperbilirubinemia remains one of the most frequent clinical diagnoses in the neonatal period. This condition may lead to the deposition of unconjugated…”
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MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes by Fernandes, Adelaide, Falcão, Ana S., Silva, Rui F. M., Brito, Maria A., Brites, Dora

“…When activated by unconjugated bilirubin (UCB), astrocytes are important sources of inflammatory mediators such as TNF‐α, IL‐1β and IL‐6, which may contribute…”
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Bilirubin injury to neurons: Contribution of oxidative stress and rescue by glycoursodeoxycholic acid by Brito, Maria A., Lima, Sílvia, Fernandes, Adelaide, Falcão, Ana S., Silva, Rui F.M., Butterfield, D. Allan, Brites, Dora

“…It is well established that high levels of unconjugated bilirubin (UCB) can be toxic to the central nervous system, and oxidative stress is emerging as a…”
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