Search Results - "Silva, Ricardo R"
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Propagating annotations of molecular networks using in silico fragmentation
Published in PLoS computational biology (01-04-2018)“…The annotation of small molecules is one of the most challenging and important steps in untargeted mass spectrometry analysis, as most of our biological…”
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Feature-based molecular networking in the GNPS analysis environment
Published in Nature methods (01-09-2020)“…Molecular networking has become a key method to visualize and annotate the chemical space in non-targeted mass spectrometry data. We present feature-based…”
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Comprehensive mass spectrometry‐guided phenotyping of plant specialized metabolites reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae
Published in The Plant journal : for cell and molecular biology (01-06-2019)“…Summary Plants produce a myriad of specialized metabolites to overcome their sessile habit and combat biotic as well as abiotic stresses. Evolution has shaped…”
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Illuminating the dark matter in metabolomics
Published in Proceedings of the National Academy of Sciences - PNAS (13-10-2015)Get full text
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5
Improved virus purification processes for vaccines and gene therapy
Published in Biotechnology and bioengineering (01-05-2015)“…ABSTRACT The downstream processing of virus particles for vaccination or gene therapy is becoming a critical bottleneck as upstream titers keep improving…”
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Distinct photo-oxidation-induced cell death pathways lead to selective killing of human breast cancer cells
Published in Cell death & disease (14-12-2020)“…Lack of effective treatments for aggressive breast cancer is still a major global health problem. We have previously reported that photodynamic therapy using…”
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Combination of GC-MS Molecular Networking and Larvicidal Effect against Aedes aegypti for the Discovery of Bioactive Substances in Commercial Essential Oils
Published in Molecules (Basel, Switzerland) (28-02-2022)“…Dengue is a neglected disease, present mainly in tropical countries, with more than 5.2 million cases reported in 2019. Vector control remains the most…”
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Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols
Published in Journal of natural products (Washington, D.C.) (24-03-2017)“…In order to expedite the rapid and efficient discovery and isolation of novel specialized metabolites, while minimizing the waste of resources on rediscovery…”
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Coupling Targeted and Untargeted Mass Spectrometry for Metabolome-Microbiome-Wide Association Studies of Human Fecal Samples
Published in Analytical chemistry (Washington) (18-07-2017)“…Increasing appreciation of the gut microbiome’s role in health motivates understanding the molecular composition of human feces. To analyze such complex…”
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Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages
Published in Food chemistry (01-01-2020)“…•First large-scale food composition analysis using mass spectral molecular networking.•A methodological pipeline for compound discovery applicable to diverse…”
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Lifestyle chemistries from phones for individual profiling
Published in Proceedings of the National Academy of Sciences - PNAS (29-11-2016)“…Imagine a scenario where personal belongings such as pens, keys, phones, or handbags are found at an investigative site. It is often valuable to the…”
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Computational Removal of Undesired Mass Spectral Features Possessing Repeat Units via a Kendrick Mass Filter
Published in Journal of the American Society for Mass Spectrometry (01-02-2019)“…Polymers are a common component of chemical background which complicates data analysis and can impair interpretation. Undesired chemical background cannot…”
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Assessing Specialized Metabolite Diversity in the Cosmopolitan Plant Genus Euphorbia L
Published in Frontiers in plant science (02-07-2019)“…Coevolutionary theory suggests that an arms race between plants and herbivores yields increased plant specialized metabolite diversity and the geographic…”
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Metabolomics Analysis of Bacterial Pathogen Burkholderia thailandensis and Mammalian Host Cells in Co-culture
Published in ACS infectious diseases (12-08-2022)“…The Tier 1 HHS/USDA Select Agent Burkholderia pseudomallei is a bacterial pathogen that is highly virulent when introduced into the respiratory tract and…”
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Anthocyanin Profile of Elderberry Juice: A Natural-Based Bioactive Colouring Ingredient with Potential Food Application
Published in Molecules (Basel, Switzerland) (26-06-2019)“…Elderberry ( L.) is a widely disseminated plant that produces bright black berries containing high quantities of anthocyanins, acknowledged for their…”
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Rosemary ( Rosmarinus officinalis L.) Glycolic Extract Protects Liver Mitochondria from Oxidative Damage and Prevents Acetaminophen-Induced Hepatotoxicity
Published in Antioxidants (01-03-2023)“…L. (rosemary) is an aromatic culinary herb. Native to the Mediterranean region, it is currently cultivated worldwide. In addition to its use as a condiment in…”
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Novel Pseudomonas Species Prevent the Growth of the Phytopathogenic Fungus Aspergillus flavus
Published in Biotech (Basel) (30-03-2024)“…In response to the escalating demand for sustainable agricultural methodologies, the utilization of microbial volatile organic compounds (VOCs) as antagonists…”
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Metabolic Profiling of Interspecies Interactions During Sessile Bacterial Cultivation Reveals Growth and Sporulation Induction in Paenibacillus amylolyticus in Response to Xanthomonas retroflexus
Published in Frontiers in cellular and infection microbiology (29-03-2022)“…The toolbox available for microbiologists to study interspecies interactions is rapidly growing, and with continuously more advanced instruments, we are able…”
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Differences in Cystic Fibrosis-Associated Burkholderia spp. Bacteria Metabolomes after Exposure to the Antibiotic Trimethoprim
Published in ACS infectious diseases (08-05-2020)“…The Burkholderia cepacia complex is a group of closely related bacterial species with large genomes that infect immunocompromised individuals and those living…”
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Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
Published in Nature biotechnology (01-08-2016)“…GNPS is an open-access community-curated analysis platform for sharing natural product mass spectrometry data that enables continuous, automatic reanalysis of…”
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