Search Results - "Silva, Raquel Lima"

Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature by Shen, Jikui, Frye, Maike, Lee, Bonnie L, Reinardy, Jessica L, McClung, Joseph M, Ding, Kun, Kojima, Masashi, Xia, Huiming, Seidel, Christopher, Lima e Silva, Raquel, Dong, Aling, Hackett, Sean F, Wang, Jiangxia, Howard, Brian W, Vestweber, Dietmar, Kontos, Christopher D, Peters, Kevin G, Campochiaro, Peter A

“…Retinal and choroidal neovascularization (NV) and vascular leakage contribute to visual impairment in several common ocular diseases. The angiopoietin/TIE2…”
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Sustained delivery of acriflavine from the suprachoroidal space provides long term suppression of choroidal neovascularization by Hackett, Sean F., Fu, Jie, Kim, Yoo Chun, Tsujinaka, Hiroki, Shen, Jikui, Lima e Silva, Raquel, Khan, Mahmood, Hafiz, Zibran, Wang, Tao, Shin, Matthew, Anders, Nicole M., He, Ping, Ensign, Laura M., Hanes, Justin, Campochiaro, Peter A.

“…Hypoxia-inducible factor-1 (HIF-1) has been implicated in the pathogenesis of choroidal neovascularization (NV) and is an appealing target because it increases…”
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AAV8-vectored suprachoroidal gene transfer produces widespread ocular transgene expression by Ding, Kun, Shen, Jikui, Hafiz, Zibran, Hackett, Sean F, Silva, Raquel Lima E, Khan, Mahmood, Lorenc, Valeria E, Chen, Daiqin, Chadha, Rishi, Zhang, Minie, Van Everen, Sherri, Buss, Nicholas, Fiscella, Michele, Danos, Olivier, Campochiaro, Peter A

“…There has been great progress in ocular gene therapy, but delivery of viral vectors to the retinal pigmented epithelium (RPE) and retina can be challenging…”
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Gelling hypotonic polymer solution for extended topical drug delivery to the eye by Kim, Yoo Chun, Shin, Matthew D., Hackett, Sean F., Hsueh, Henry T., Lima e Silva, Raquel, Date, Abhijit, Han, Hyounkoo, Kim, Byung-Jin, Xiao, Amy, Kim, Youngwook, Ogunnaike, Laolu, Anders, Nicole M., Hemingway, Avelina, He, Ping, Jun, Albert S., McDonnell, Peter J., Eberhart, Charles, Pitha, Ian, Zack, Donald J., Campochiaro, Peter A., Hanes, Justin, Ensign, Laura M.

“…Eye-drop formulations should hold as high a concentration of soluble drug in contact with ocular epithelium for as long as possible. However, eye tears and…”
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Tyrosine kinase blocking collagen IV-derived peptide suppresses ocular neovascularization and vascular leakage by Silva, Raquel Lima E, Kanan, Yogita, Mirando, Adam C, Kim, Jayoung, Shmueli, Ron B, Lorenc, Valeria E, Fortmann, Seth D, Sciamanna, Jason, Pandey, Niranjan B, Green, Jordan J, Popel, Aleksander S, Campochiaro, Peter A

“…Vascular endothelial growth factor (VEGF)-neutralizing proteins provide benefit in several retinal and choroidal vascular diseases, but some patients still…”
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Mecamylamine Suppresses Basal and Nicotine-Stimulated Choroidal Neovascularization by Kiuchi, Katsuji, Matsuoka, Masato, Wu, Jenny C, Lima e Silva, Raquel, Kengatharan, Muralitharan, Verghese, Mary, Ueno, Shinji, Yokoi, Katsutoshi, Khu, Naw Htee, Cooke, John P, Campochiaro, Peter A

“…Nicotinic acetylcholine receptors (nAChR) are best known for their role in neurotransmission, but they have recently been demonstrated on vascular endothelial…”
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A collagen IV-derived peptide disrupts α5β1 integrin and potentiates Ang2/Tie2 signaling by Mirando, Adam C, Shen, Jikui, Silva, Raquel Lima E, Chu, Zenny, Sass, Nicholas C, Lorenc, Valeria E, Green, Jordan J, Campochiaro, Peter A, Popel, Aleksander S, Pandey, Niranjan B

“…The angiopoietin (Ang)/Tie2 signaling pathway is essential for maintaining vascular homeostasis, and its dysregulation is associated with several diseases…”
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Topical pazopanib blocks VEGF-induced vascular leakage and neovascularization in the mouse retina but is ineffective in the rabbit by Iwase, Takeshi, Oveson, Brian C, Hashida, Noriyasu, Lima e Silva, Raquel, Shen, Jikui, Krauss, Achim H, Gale, David C, Adamson, Peter, Campochiaro, Peter A

“…To test the effect of pazopanib, a tyrosine kinase inhibitor that blocks VEGF and platelet-derived growth factor (PDGF) receptors and c-Kit, on vascular…”
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VEGF-TRAPR1R2 suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrier by Saishin, Yoshitsugu, Saishin, Yumiko, Takahashi, Kyoichi, Silva, Raquel Lima e, Hylton, Donna, Rudge, John S., Wiegand, Stanley J., Campochiaro, Peter A.

“…Vascular endothelial growth factor (VEGF) plays a central role in the development of retinal neovascularization and diabetic macular edema. There is also…”
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Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling by Mirando, Adam C, Lima E Silva, Raquel, Chu, Zenny, Campochiaro, Peter A, Pandey, Niranjan B, Popel, Aleksander S

“…Persistent inflammation is a complication associated with many ocular diseases. Changes in ocular vessels can amplify disease responses and contribute to…”
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SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization by Lima e Silva, Raquel, Shen, Jikui, Hackett, Sean F, Kachi, Shu, Akiyama, Hideo, Kiuchi, Katsuji, Yokoi, Katsutoshi, Hatara, Maria C, Lauer, Thomas, Aslam, Sadia, Gong, Yuan Yuan, Xiao, Wei-Hong, Khu, Naw Htee, Thut, Catherine, Campochiaro, Peter A

“…Hypoxia causes increased expression of several proteins that have the potential to promote neovascularization. Vascular endothelial growth factor (VEGF) is…”
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Hepatocyte growth factor is upregulated in ischemic retina and contributes to retinal vascular leakage and neovascularization by Lorenc, Valeria E., Lima e Silva, Raquel, Hackett, Sean F., Fortmann, Seth D., Liu, Yuanyuan, Campochiaro, Peter A.

“…In patients with macular edema due to ischemic retinopathy, aqueous levels of hepatocyte growth factor (HGF) correlate with edema severity. We tested whether…”
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Intraocular injection of an aptamer that binds PDGF-B: A potential treatment for proliferative retinopathies by Akiyama, Hideo, Kachi, Shu, E Silva, Raquel Lima, Umeda, Naoyasu, Hackett, Sean F., McCauley, Dilara, McCauley, Thomas, Zoltoski, Anna, Epstein, David M., Campochiaro, Peter A.

“…Platelet‐derived growth factor‐B (PDGF‐B) has been implicated in the pathogenesis of proliferative retinopathies and other scarring disorders in the eye. In…”
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Three-Dimensional Transport Model for Intravitreal and Suprachoroidal Drug Injection by Zhang, Yu, Bazzazi, Hojjat, Lima E Silva, Raquel, Pandey, Niranjan B, Green, Jordan J, Campochiaro, Peter A, Popel, Aleksander S

“…Quantitative understanding of the transport of therapeutic macromolecules following intraocular injections is critical for the design of efficient strategies…”
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Handgrip strength accuracy as discriminator of functional independence in centenarian women by Fortunato, Artur Rodrigues, Silva, Raquel Ester Lima da, Mazo, Giovana Zarpellon

“…Abstract The aim of this study was to verify and compare handgrip strength (HS) with activities of the daily living (ADL) and to identify the cutoff point of…”
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Anisotropic poly(lactic-co-glycolic acid) microparticles enable sustained release of a peptide for long-term inhibition of ocular neovascularization by Kim, Jayoung, Lima e Silva, Raquel, Shmueli, Ron B., Mirando, Adam C., Tzeng, Stephany Y., Pandey, Niranjan B., Ben-Akiva, Elana, Popel, Aleksander S., Campochiaro, Peter A., Green, Jordan J.

“…[Display omitted] Leading causes of vision loss include neovascular age-related macular degeneration (NVAMD) and macular edema (ME), which both require…”
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Sustained delivery of a HIF-1 antagonist for ocular neovascularization by Iwase, Takeshi, Fu, Jie, Yoshida, Tsunehiko, Muramatsu, Daisuke, Miki, Akiko, Hashida, Noriyasu, Lu, Lili, Oveson, Brian, Lima e Silva, Raquel, Seidel, Christopher, Yang, Ming, Connelly, Sheila, Shen, Jikui, Han, Bing, Wu, Mingsheng, Semenza, Gregg L., Hanes, Justin, Campochiaro, Peter A.

“…Doxorubicin (DXR) and daunorubicin (DNR) inhibit hypoxia-inducible factor-1 (HIF-1) transcriptional activity by blocking its binding to DNA. Intraocular…”
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Suppression and Regression of Choroidal Neovascularization by Polyamine Analogues by Silva, Raquel Lima e, Saishin, Yoshitsugu, Saishin, Yumiko, Akiyama, Hideo, Kachi, Shu, Aslam, Sadia, Rogers, Brian, Deering, Tye, Gong, Yuan Yuan, Hackett, Sean F, Lai, Hong, Frydman, Benjamin J, Valasinas, Aldonia, Marton, Laurence J, Campochiaro, Peter A

“…Polyamine analogues inhibit tumor growth in vitro and in vivo, and oligoamines with a chain length of 10, 12, or 14 are particularly potent. This study was…”
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Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide by Shmueli, Ron B, Ohnaka, Masayuki, Miki, Akiko, Pandey, Niranjan B, Lima e Silva, Raquel, Koskimaki, Jacob E, Kim, Jayoung, Popel, Aleksander S, Campochiaro, Peter A, Green, Jordan J

“…Abstract Aberrant angiogenesis can cause or contribute to a number of diseases such as neovascular age-related macular degeneration (NVAMD). While current…”
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A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization by Wojnarowicz, Paulina M., Lima e Silva, Raquel, Ohnaka, Masayuki, Lee, Sang Bae, Chin, Yvette, Kulukian, Anita, Chang, Sung-Hee, Desai, Bina, Garcia Escolano, Marta, Shah, Riddhi, Garcia-Cao, Marta, Xu, Sijia, Kadam, Rashmi, Goldgur, Yehuda, Miller, Meredith A., Ouerfelli, Ouathek, Yang, Guangli, Arakawa, Tsutomu, Albanese, Steven K., Garland, William A., Stoller, Glenn, Chaudhary, Jaideep, Norton, Larry, Soni, Rajesh Kumar, Philip, John, Hendrickson, Ronald C., Iavarone, Antonio, Dannenberg, Andrew J., Chodera, John D., Pavletich, Nikola, Lasorella, Anna, Campochiaro, Peter A., Benezra, Robert

“…Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive…”
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