Therapeutic Effects of Probiotic Minas Frescal Cheese on the Attenuation of Ulcerative Colitis in a Murine Model

Inflammatory bowel diseases (IBDs) constitute disturbances of gastrointestinal tract that cause irreversible changes in the structure and function of tissues. Ulcerative colitis (UC), the most frequent IBD in the population, is characterized by prominent inflammation of the human colon. Functional f...

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Published in:	Frontiers in microbiology Vol. 12; p. 623920
Main Authors:	Cordeiro, Bárbara F, Alves, Juliana L, Belo, Giovanna A, Oliveira, Emiliano R, Braga, Marina P, da Silva, Sara H, Lemos, Luisa, Guimarães, Jonas T, Silva, Ramon, Rocha, Ramon S, Jan, Gwénaël, Le Loir, Yves, Silva, Marcia Cristina, Freitas, Mônica Q, Esmerino, Erick A, Gala-García, Alfonso, Ferreira, Enio, Faria, Ana Maria C, Cruz, Adriano G, Azevedo, Vasco, do Carmo, Fillipe L R
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media 02-03-2021 Frontiers Media S.A
Subjects:	cheese colitis functional food Human health and pathology inflammatory bowel disease Lactococcus lactis Life Sciences Microbiology Microbiology and Parasitology probiotic Lactococcus lactis probiotic functional food colitis inflammatory bowel disease cheese
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Summary:	Inflammatory bowel diseases (IBDs) constitute disturbances of gastrointestinal tract that cause irreversible changes in the structure and function of tissues. Ulcerative colitis (UC), the most frequent IBD in the population, is characterized by prominent inflammation of the human colon. Functional foods containing probiotic bacteria have been studied as adjuvants to the treatment or prevention of IBDs. The selected probiotic strain NCDO 2118 ( NCDO 2118) exhibits immunomodulatory effects, with promising results in UC mouse model induced by dextran sodium sulfate (DSS). Additionally, cheese is a dairy food that presents high nutritional value, besides being a good delivery system that can be used to improve survival and enhance the therapeutic effects of probiotic bacteria in the host. Therefore, this work investigated the probiotic therapeutic effects of an experimental Minas Frescal cheese containing NCDO 2118 in DSS-induced colitis in mice. During colitis induction, mice that consumed the probiotic cheese exhibited reduced in the severity of colitis, with attenuated weight loss, lower disease activity index, limited shortening of the colon length, and reduced histopathological score. Moreover, probiotic cheese administration increased gene expression of tight junctions' proteins , , , and in the colon and increase IL-10 release in the spleen and lymph nodes. In this way, this work demonstrates that consumption of probiotic Minas Frescal cheese, containing NCDO 2118, prevents the inflammatory process during DSS-induced colitis in mice, opening perspectives for the development of new probiotic functional foods for personalized nutrition in the context of IBD.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors share senior authorship Reviewed by: Marcello Chieppa, National Institute of Gastroenterology S. de Bellis Research Hospital (IRCCS), Italy; Guillaume Sarrabayrouse, Vall d'Hebron Research Institute (VHIR), Spain This article was submitted to Food Microbiology, a section of the journal Frontiers in Microbiology Edited by: Paola Lavermicocca, Italian National Research Council, Italy
ISSN:	1664-302X 1664-302X
DOI:	10.3389/fmicb.2021.623920