Search Results - "Silva, Rafaela José"
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Cyclooxygenase (COX)-2 modulates Toxoplasma gondii infection, immune response and lipid droplets formation in human trophoblast cells and villous explants
Published in Scientific reports (16-06-2021)“…Congenital toxoplasmosis is represented by the transplacental passage of Toxoplasma gondii from the mother to the fetus. Our studies demonstrated that T…”
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Trypanosoma cruzi P21 recombinant protein modulates Toxoplasma gondii infection in different experimental models of the human maternal–fetal interface
Published in Frontiers in immunology (16-10-2023)“…Introduction Toxoplasma gondii is the etiologic agent of toxoplasmosis, a disease that affects about one-third of the human population. Most infected…”
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Pravastatin and simvastatin inhibit the adhesion, replication and proliferation of Toxoplasma gondii (RH strain) in HeLa cells
Published in Acta tropica (01-03-2017)“…[Display omitted] •Simvastatin and pravastatin evaluated in cells infected with Toxoplasma gondii.•Analyzed adhesion, cell infection and proliferation of T…”
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Increased Toxoplasma gondii Intracellular Proliferation in Human Extravillous Trophoblast Cells (HTR8/SVneo Line) Is Sequentially Triggered by MIF, ERK1/2, and COX-2
Published in Frontiers in microbiology (24-04-2019)“…Macrophage migration inhibitory factor (MIF) is a potent pro-inflammatory cytokine, which mediates the regulation of diverse cellular functions. It is produced…”
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Systematic Review and Meta-Analysis of Congenital Toxoplasmosis Diagnosis: Advances and Challenges
Published in Journal of tropical medicine (21-02-2024)“…Objective. To understand how congenital toxoplasmosis (CT) diagnosis has evolved over the years, we performed a systematic review and meta-analysis to…”
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Cyclooxygenase (COX)-2 Inhibitors Reduce Toxoplasma gondii Infection and Upregulate the Pro-inflammatory Immune Response in Calomys callosus Rodents and Human Monocyte Cell Line
Published in Frontiers in microbiology (12-02-2019)“…is able to infect a wide range of vertebrates, including humans. Studies show that cyclooxygenase-2 (COX-2) is a modulator of immune response in multiple types…”
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Biogenic Silver Nanoparticles Can Control Toxoplasma gondii Infection in Both Human Trophoblast Cells and Villous Explants
Published in Frontiers in microbiology (21-01-2021)“…The combination of sulfadiazine and pyrimethamine plus folinic acid is the conventional treatment for congenital toxoplasmosis. However, this classical…”
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Rottlerin-mediated inhibition of Toxoplasma gondii growth in BeWo trophoblast-like cells
Published in Scientific reports (28-04-2017)“…Autophagy is a crucial and physiological process for cell survival from yeast to mammals, including protozoan parasites. Toxoplasma gondii , an intracellular…”
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BEWO trophoblast cells and Toxoplasma gondii infection modulate cell death mechanisms in THP-1 monocyte cells by interference in the expression of death receptor and intracellular proteins
Published in Tissue & cell (01-12-2021)“…•T. gondii infection induces cell death and inhibits apoptosis in THP-1 cells.•Soluble factors secreted by BeWo cells induces cell death and apoptosis in THP-1…”
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Brazilian strains of Toxoplasma gondii are controlled by azithromycin and modulate cytokine production in human placental explants
Published in Journal of biomedical science (21-01-2019)“…Toxoplasma gondii is a protozoan parasite that causes congenital toxoplasmosis by transplacental transmission. Parasite strains are genetically diverse and…”
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Predicted impacts of government policies and actions on the SARS-CoV-2 disease in the northwestern Himalayan region, India
Published in Journal of public health (01-04-2023)“…Aim The outbreak of the new coronavirus pandemic (SARS-CoV-2) was initiated in December 2019, and within a couple of months it became a global health…”
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Macrophage Migration Inhibitory Factor contributes to drive phenotypic and functional macrophages activation in response to Toxoplasma gondii infection
Published in Immunobiology (1979) (01-05-2023)“…Cytokines are small molecules secreted by numerous cells. Macrophage Migration Inhibitory Factor (MIF) is a cytokine initially described due to its function of…”
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Experimental models of maternal–fetal interface and their potential use for nanotechnology applications
Published in Cell biology international (01-01-2020)“…During pregnancy, the placenta regulates the transfer of oxygen, nutrients, and residual products between the maternal and fetal bloodstreams and is a key…”
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Azithromycin treatment is able to control the infection by two genotypes of Toxoplasma gondii in human trophoblast BeWo cells
Published in Experimental parasitology (01-10-2017)“…Trophoblast infection by Toxoplasma gondii plays a pivotal role in the vertical transmission of toxoplasmosis. Here, we investigate whether the antibiotic…”
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Anti-parasitic effect on Toxoplasma gondii induced by BnSP-7, a Lys49-phospholipase A2 homologue from Bothrops pauloensis venom
Published in Toxicon (Oxford) (01-09-2016)“…Toxoplasmosis affects a third of the global population and presents high incidence in tropical areas. Its great relevance in public health has led to a search…”
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Polyalthic acid and oleoresin from Copaifera trapezifolia Hayne reduce Toxoplasma gondii growth in human villous explants, even triggering an anti-inflammatory profile
Published in Experimental parasitology (01-07-2023)“…Due to the lack of efficient antiparasitic therapy and vaccines, as well as emerging resistance strains, congenital toxoplasmosis is still a public health…”
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LPS-mediated activation of TLR4 controls Toxoplasma gondii growth in human trophoblast cell (BeWo) and human villous explants in a dependent-manner of TRIF, MyD88, NF-κB and cytokines
Published in Tissue & cell (01-10-2022)“…We evaluated the influence of the Toll-like receptor (TLR)-4 pathways on BeWo, JEG-3 and HTR-8/SVneo cells, as well as in human villous explants infected with…”
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Macrophage migration inhibitory factor (MIF) and pregnancy may impact the balance of intestinal cytokines and the development of intestinal pathology caused by Toxoplasma gondii infection
Published in Cytokine (Philadelphia, Pa.) (01-12-2020)“…•MIF is up-regulated in gut of pregnant and infected mice.•Pregnancy increases T. gondii parasitism in small intestine.•T. gondii infection changes gut…”
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Insights into anti-parasitism induced by a C-type lectin from Bothrops pauloensis venom on Toxoplasma gondii
Published in International journal of biological macromolecules (01-03-2015)“…Here we evaluate the effects of BpLec, a C-type lectin isolated from Bothrops pauloensis snake venom, on Toxoplasma gondii parasitism. BpLec (0.195–12.5μg/mL)…”
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Immunological mechanisms, parasite-host interaction and alternative treatments for toxoplasmosis at maternal-fetal interface: An update
Published in Placenta (Eastbourne) (01-08-2024)Get full text
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