Search Results - "Silva, Rafael G G"

Human 2′‐Deoxynucleoside 5′‐Phosphate N‐Hydrolase 1: The Catalytic Roles of Tyr24 and Asp80 by Carberry, Anna E., Devi, Suneeta, Harrison, David J., Silva, Rafael G.

“…The human enzyme 2′‐deoxynucleoside 5′‐phosphate N‐hydrolase 1 (HsDNPH1) catalyses the hydrolysis of 5‐hydroxymethyl‐2′‐deoxyuridine 5′‐phosphate to generate…”
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Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme by Silva, Rafael G, Murkin, Andrew S, Schramm, Vern L

“…Contributions of fast (femtosecond) dynamic motion to barrier crossing at enzyme catalytic sites is in dispute. Human purine nucleoside phosphorylase (PNP)…”
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Anthers in blue: A hidden rhapsody in Amazonian Eriocaulaceae by Andrino, Caroline O., Santana, Pamela C., Lovo, Juliana, Barbosa‐Silva, Rafael G., Albuquerque‐Lima, Sinzinando, Zappi, Daniela C.

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Structure, dynamics, and molecular inhibition of the Staphylococcus aureus m1A22-tRNA methyltransferase TrmK by Sweeney, Pamela, Galliford, Ashleigh, Kumar, Abhishek, Raju, Dinesh, Krishna, Naveen B., Sutherland, Emmajay, Leo, Caitlin J., Fisher, Gemma, Lalitha, Roopa, Muthuraj, Likith, Sigamani, Gladstone, Oehler, Verena, Synowsky, Silvia, Shirran, Sally L., Gloster, Tracey M., Czekster, Clarissa M., Kumar, Pravin, da Silva, Rafael G.

“…The enzyme m1A22-tRNA methyltransferase (TrmK) catalyzes the transfer of a methyl group to the N1 of adenine 22 in bacterial tRNAs. TrmK is essential for…”
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Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation by Fisher, Gemma, Corbella, Marina, Alphey, Magnus S., Nicholson, John, Read, Benjamin J., Kamerlin, Shina C. L., da Silva, Rafael G.

“…ATP phosphoribosyltransferase catalyses the first step of histidine biosynthesis and is controlled via a complex allosteric mechanism where the regulatory…”
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A new species of Bonnetia Mart. (Bonnetiaceae) from the Pantepui of South America by Barbosa-Silva, Rafael G, Torke, Benjamin M, Viana, Pedro L

“…is the most representative genus of the Pantepui woody flora and is among the groups with the greatest endemism in the local flora. The genus has 28 currently…”
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Allosteric activation unveils protein-mass modulation of ATP phosphoribosyltransferase product release by Read, Benjamin J., Mitchell, John B. O., da Silva, Rafael G.

“…Heavy-isotope substitution into enzymes slows down bond vibrations and may alter transition-state barrier crossing probability if this is coupled to fast…”
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Preliminary placement and new records of an overlooked Amazonian tree, Christiana mennegae (Malvaceae) by Barbosa-Silva, Rafael G, Coutinho, Thales Silva, Vasconcelos, Santelmo, da Silva, Delmo Fonseca, Oliveira, Guilherme, Zappi, Daniela C

“…is a phylogenetically enigmatic taxon and represents a case in point of a species whose presence escaped the radar of the Amazon lists and the Brazilian Flora…”
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Expanding the Distribution of Prosthechea jauana (Orchidaceae) in the Pantepui and Highlighting the Urgent Need for Conservation Strategies in the Region in Face of Climate Change by Vieira, Tiago L, Barbosa-Silva, Rafael G, Acosta, André L, van den Berg, Cássio

“…has been recognized as an orchid species endemic to the Venezuelan tepui. The first record of in Brazil is presented here, also from a tepui in the Southern…”
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Superhydrophobic Surfaces Based on Nickel Stearate: An Innovative Approach to Coatings on 7050 Aeronautical Aluminum Alloy by Silva, Jedaías J. da, Guimarães, Ana L. C., Silva Filho, Walter L. C. da, Silva, Rafael G. C. da, Malta, Maria I. C., Morais, Dayanne D. S., Urtiga Filho, Severino L., Vieira, Magda R. S.

“…A metallic surface can exhibit low wettability through the formation of a rough structure with micro/nanometric dimensions combined with a surface…”
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An Exceptionally Potent Inhibitor of Human CD73 by Bowman, Christine E, da Silva, Rafael G, Pham, Amber, Young, Stephen W

“…We recently reported the initiation of a Phase I clinical trial with AB680, a potent human CD73 inhibitor, being developed for the treatment of solid tumors…”
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Synergistic Antifungal Activity of Synthetic Peptides and Antifungal Drugs against Candida albicans and C. parapsilosis Biofilms by Bezerra, Leandro P, Freitas, Cleverson D T, Silva, Ayrles F B, Amaral, Jackson L, Neto, Nilton A S, Silva, Rafael G G, Parra, Aura L C, Goldman, Gustavo H, Oliveira, Jose T A, Mesquita, Felipe P, Souza, Pedro F N

“…and are biofilm-forming yeasts responsible for bloodstream infections that can cause death. Synthetic antimicrobial peptides (SAMPs) are considered to be new…”
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Human 2′-Deoxynucleoside 5′-Phosphate N‑Hydrolase 1: Mechanism of 2′-Deoxyuridine 5′-Monophosphate Hydrolysis by Devi, Suneeta, Carberry, Anna E., Zickuhr, Greice M., Dickson, Alison L., Harrison, David J., da Silva, Rafael G.

“…The enzyme 2′-deoxynucleoside 5′-phosphate N-hydrolase 1 (DNPH1) catalyzes the N-ribosidic bond cleavage of 5-hydroxymethyl-2′-deoxyuridine 5′-monophosphate to…”
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Crystal Structure, Steady-State, and Pre-Steady-State Kinetics of Acinetobacter baumannii ATP Phosphoribosyltransferase by Read, Benjamin J., Cadzow, Andrew F., Alphey, Magnus S., Mitchell, John B. O., da Silva, Rafael G.

“…The first step of histidine biosynthesis in Acinetobacter baumannii, the condensation of ATP and 5-phospho-α-d-ribosyl-1-pyrophosphate to produce N…”
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Snapshots of the Reaction Coordinate of a Thermophilic 2′-Deoxyribonucleoside/ribonucleoside Transferase by Tang, Peijun, Harding, Christopher J., Dickson, Alison L., da Silva, Rafael G., Harrison, David J., Czekster, Clarissa Melo

“…Nucleosides are ubiquitous to life and are required for the synthesis of DNA, RNA, and other molecules crucial for cell survival. Despite the notoriously…”
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Mapping the Structural Path for Allosteric Inhibition of a Short-Form ATP Phosphoribosyltransferase by Histidine by Thomson, Catherine M, Alphey, Magnus S, Fisher, Gemma, da Silva, Rafael G

“…ATP phosphoribosyltransferase (ATPPRT) catalyzes the first step of histidine biosynthesis, being allosterically inhibited by the final product of the pathway…”
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Mass-Dependent Bond Vibrational Dynamics Influence Catalysis by HIV-1 Protease by Kipp, D. Randal, Silva, Rafael G, Schramm, Vern L

“…Protein motions that occur on the microsecond to millisecond time scale have been linked to enzymatic rates observed for catalytic turnovers, but not to…”
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Transition States for Psychrophilic and Mesophilic (R)‑3-Hydroxybutyrate Dehydrogenase-Catalyzed Hydride Transfer at Sub-zero Temperatures by Machado, Teresa F. G, Purg, Miha, Åqvist, Johan, da Silva, Rafael G

“…(R)-3-Hydroxybutyrate dehydrogenase (HBDH) catalyzes the NADH-dependent reduction of 3-oxocarboxylates to (R)-3-hydroxycarboxylates. The active sites of a pair…”
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Catalytic Cycle of the Bifunctional Enzyme Phosphoribosyl-ATP Pyrophosphohydrolase/Phosphoribosyl-AMP Cyclohydrolase by Fisher, Gemma, Pečaver, Ennio, Read, Benjamin J., Leese, Susannah K., Laing, Erin, Dickson, Alison L., Czekster, Clarissa M., da Silva, Rafael G.

“…The bifunctional enzyme phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-AMP cyclohydrolase (HisIE) catalyzes the second and third steps of histidine…”
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Linear Eyring Plots Conceal a Change in the Rate-Limiting Step in an Enzyme Reaction by Machado, Teresa F. G, Gloster, Tracey M, da Silva, Rafael G

“…The temperature dependence of psychrophilic and mesophilic (R)-3-hydroxybutyrate dehydrogenase steady-state rates yields nonlinear and linear Eyring plots,…”
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