Associations of human papillomavirus (HPV) genotypes and related risk factors in a cohort of women living with HIV in a Brazilian countryside city

Associations of human papillomavirus (HPV) genotypes and related risk factors in a cohort of women living with HIV in a Brazilian countryside city

The human papillomavirus (HPV) is associated with cervical abnormalities. People living with HIV are more susceptible to HPV. Campos dos Goytacazes implemented the quadrivalent HPV vaccine (4vHPV) for women living with HIV (WLWH) in 2011, 4 years before the Brazilian public vaccination program. We a...

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Bibliographic Details
Published in:Journal of medical virology Vol. 94; no. 6; pp. 2802 - 2810
Main Authors: Kury, Charbell M. H., Guimaraes, Gabriela R., Leandro, Cinthia G., Fernandes, Lorena A., Silva, Paulo Ricardo T., Petraglia, Tania Cristina, Cruz, Oswaldo G., Carneiro, Rodrigo, Cavalcanti, Silvia M. B.
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01-06-2022
Subjects:
Abnormalities
Adult
Alphapapillomavirus
Brazil - epidemiology
CD4 antigen
Cervical cancer
Child
Children
Cohort Studies
Female
Genotype
Genotypes
Genotyping
HIV
HIV Infections - complications
HIV Infections - epidemiology
Human immunodeficiency virus
human immunodeficiency virus (HIV)
Human papillomavirus
human papillomavirus (HPV)
Humans
Immunization
Infections
Middle Aged
molecular typing
Multivariate analysis
Papillomaviridae - genetics
Papillomavirus Infections - epidemiology
Papillomavirus Infections - prevention & control
Papillomavirus Vaccines
Prospective Studies
quadrivalent vaccine against HPV
Risk analysis
Risk Factors
Rural areas
Sexual partners
Sexually transmitted diseases
STD
Vaccination
Vaccines
Virology
Brazil
human papillomavirus (HPV)
human immunodeficiency virus (HIV)
quadrivalent vaccine against HPV
molecular typing
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Summary:The human papillomavirus (HPV) is associated with cervical abnormalities. People living with HIV are more susceptible to HPV. Campos dos Goytacazes implemented the quadrivalent HPV vaccine (4vHPV) for women living with HIV (WLWH) in 2011, 4 years before the Brazilian public vaccination program. We aimed to characterize the genomic diversity and predictors of HPV infection in WLWH through a prospective cohort study. After the consent form was received, a questionnaire was applied and an endocervical sample was collected. For genotyping, a microarray HPV technique was performed. Two intervention moments were performed: T1, the initial moment, with collection and vaccination; T2 moment, 2 years after T1. Univariate and multivariate analyses were performed. The T1 moment cohort was formed by 146 women,107 belonging to Group 1(HPV‐negative) and 39 to Group 2 (HPV‐positive). The variables age, marital status, number of children, number of sexual partners, and CD4 count were protective against HPV. The variables number of sexual partners, marital status, and the number of children lost significance in multivariate analysis. Concerning T2 moment, 42 patients were followed with three positive cases. The use of 4vHPV is beneficial for this population and should also be recommended at an age from 26 to 45 years inside the public vaccination program. Key Points/Highlights The prevalence of human papillomavirus (HPV) infection in women living with HIV (WLWH) was 26.7% (39 women). Of 35 WLWH infected with recognized HPV types, 88.5% had a genotype included in 4vHPV included in the public program. Brazilian Government should recommend 4vHPV for WLWH up to45 years.
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ISSN:0146-6615
1096-9071
1096-9071
DOI:10.1002/jmv.27582