Search Results - "Silva, Patrícia M M"

Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research by Pinto, Bárbara, Henriques, Ana C, Silva, Patrícia M A, Bousbaa, Hassan

“…Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture techniques to test in vitro anti-tumor drugs prior to in vivo testing…”
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Robotic assisted gait as a tool for rehabilitation of individuals with spinal cord injury: a systematic review by Holanda, Ledycnarf J, Silva, Patrícia M M, Amorim, Thiago C, Lacerda, Matheus O, Simão, Camila R, Morya, Edgard

“…Spinal cord injury (SCI) is characterized by a total or partial deficit of sensory and motor pathways. Impairments of this injury compromise muscle recruitment…”
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BP-M345 as a Basis for the Discovery of New Diarylpentanoids with Promising Antimitotic Activity by Moreira, Joana, Silva, Patrícia M A, Castro, Eliseba, Saraiva, Lucília, Pinto, Madalena, Bousbaa, Hassan, Cidade, Honorina

“…Recently, the diarylpentanoid ( ) has been identified as a potent in vitro growth inhibitor of cancer cells, with a GI value between 0.17 and 0.45 µM, showing…”
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Antagonizing the spindle assembly checkpoint silencing enhances paclitaxel and Navitoclax-mediated apoptosis with distinct mechanistic by Henriques, Ana C., Silva, Patrícia M. A., Sarmento, Bruno, Bousbaa, Hassan

“…Antimitotic drugs arrest cells in mitosis through chronic activation of the spindle assembly checkpoint (SAC), leading to cell death. However, drug-treated…”
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Second-Generation Antimitotics in Cancer Clinical Trials by Novais, Pedro, Silva, Patrícia M. A., Amorim, Isabel, Bousbaa, Hassan

“…Mitosis represents a promising target to block cancer cell proliferation. Classical antimitotics, mainly microtubule-targeting agents (MTAs), such as taxanes…”
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Targeting Glucose Metabolism in Cancer Cells as an Approach to Overcoming Drug Resistance by Cunha, Andrea, Silva, Patrícia M. A, Sarmento, Bruno, Queirós, Odília

“…The “Warburg effect” consists of a metabolic shift in energy production from oxidative phosphorylation to glycolysis. The continuous activation of glycolysis…”
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Evaluation of Antitumor Activity of Xanthones Conjugated with Amino Acids by Barbosa, Flávia, Araújo, Joana, Gonçalves, Virgínia M F, Palmeira, Andreia, Cunha, Andrea, Silva, Patrícia M A, Fernandes, Carla, Pinto, Madalena, Bousbaa, Hassan, Queirós, Odília, Tiritan, Maria Elizabeth

“…Cancer is a complex disease characterized by several alterations, which confer, to the cells, the capacity to proliferate uncontrollably and to resist cellular…”
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Combination Therapy as a Promising Way to Fight Oral Cancer by Silva, João P N, Pinto, Bárbara, Monteiro, Luís, Silva, Patrícia M A, Bousbaa, Hassan

“…Oral cancer is a highly aggressive tumor with invasive properties that can lead to metastasis and high mortality rates. Conventional treatment strategies, such…”
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Exploring the Therapeutic Implications of Co-Targeting the EGFR and Spindle Assembly Checkpoint Pathways in Oral Cancer by Calheiros-Lobo, Mafalda, Silva, João P N, Pinto, Bárbara, Monteiro, Luís, Silva, Patrícia M A, Bousbaa, Hassan

“…Head and neck cancer (HNC), the sixth most common cancer worldwide, is increasing in incidence, with oral squamous cell carcinoma (OSCC) as the predominant…”
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BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity by Novais, Pedro, Silva, Patrícia M A, Moreira, Joana, Palmeira, Andreia, Amorim, Isabel, Pinto, Madalena, Cidade, Honorina, Bousbaa, Hassan

“…Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on human cancer cells. Nevertheless, at that time, the cellular…”
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Discovery of a New Chalcone-Trimethoxycinnamide Hybrid with Antimitotic Effect: Design, Synthesis, and Structure-Activity Relationship Studies by Moreira, Joana, Silva, Patrícia M A, Barros, Matilde, Saraiva, Lucília, Pinto, Madalena, Bousbaa, Hassan, Cidade, Honorina

“…In this work, the design and synthesis of a new chalcone-trimethoxycinnamide hybrid ( ) based on the combination of subunits of two promising antiproliferative…”
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Coupling Kinesin Spindle Protein and Aurora B Inhibition with Apoptosis Induction Enhances Oral Cancer Cell Killing by Silva, João P N, Pinto, Bárbara, Monteiro, Luís, Silva, Patrícia M A, Bousbaa, Hassan

“…Many proteins regulating mitosis have emerged as targets for cancer therapy, including the kinesin spindle protein (KSP) and Aurora kinase B (AurB). KSP is…”
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Maximizing Anticancer Response with MPS1 and CENPE Inhibition Alongside Apoptosis Induction by Pinto, Bárbara, Silva, João P N, Silva, Patrícia M A, Barbosa, Daniel José, Sarmento, Bruno, Tavares, Juliana Carvalho, Bousbaa, Hassan

“…Antimitotic compounds, targeting key spindle assembly checkpoint (SAC) components (e.g., MPS1, Aurora kinase B, PLK1, KLP1, CENPE), are potential alternatives…”
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Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines With Increased Expression of P-Glycoprotein by Nunes, Mariana, Silva, Patrícia M A, Coelho, Ricardo, Pinto, Carla, Resende, Albina, Bousbaa, Hassan, Almeida, Gabriela M, Ricardo, Sara

“…Debulking surgery followed by chemotherapy are the standard of care for high-grade serous carcinoma. After an initial good response to treatment, the majority…”
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New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation by Moreira, Joana, Ribeiro, Diana, Silva, Patrícia M A, Nazareth, Nair, Monteiro, Madalena, Palmeira, Andreia, Saraiva, Lucília, Pinto, Madalena, Bousbaa, Hassan, Cidade, Honorina

“…The antitumor activity of natural flavonoids has been exhaustively reported. Previously it has been demonstrated that prenylation of flavonoids allows the…”
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Antimicrobial protein rBPI21 -induced surface changes on Gram-negative and Gram-positive bacteria by Domingues, Marco M., PhD, Silva, Patrícia M., BSc, Franquelim, Henri G., PhD, Carvalho, Filomena A., PhD, Castanho, Miguel A.R.B., PhD, Santos, Nuno C., PhD

“…Abstract New classes of antibiotics, such as antimicrobial peptides or proteins (AMPs), are crucial to deal with threatening bacterial diseases. rBPI21 is an…”
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Tetracyclic Thioxanthene Derivatives: Studies on Fluorescence and Antitumor Activity by Durães, Fernando, Silva, Patrícia M. A., Novais, Pedro, Amorim, Isabel, Gales, Luís, Esteves, Cátia I. C., Guieu, Samuel, Bousbaa, Hassan, Pinto, Madalena, Sousa, Emília

“…Thioxanthones are bioisosteres of the naturally occurring xanthones. They have been described for multiple activities, including antitumor. As such, the…”
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Prenylated Chalcone 2 Acts as an Antimitotic Agent and Enhances the Chemosensitivity of Tumor Cells to Paclitaxel by Fonseca, Joana, Marques, Sandra, Silva, Patrícia M A, Brandão, Pedro, Cidade, Honorina, Pinto, Madalena M, Bousbaa, Hassan

“…We previously reported that prenylated chalcone 2 (PC2), the O-prenyl derivative (2) of 2'-hydroxy-3,4,4',5,6'-pentamethoxychalcone (1), induced cytotoxicity…”
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Glucocorticoids decrease the numbers and activation of mast cells by inducing the transactivation receptors of AGEs by Santoro, Tassia, Azevedo, Carolina T., e Silva, Patrícia M. R., Martins, Marco A., Carvalho, Vinicius F.

“…Glucocorticoids (GCs) are potent anti‐allergic compounds that function, at least in part, by inhibiting signaling pathways in mast cells. We hypothesized that…”
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A Pyranoxanthone as a Potent Antimitotic and Sensitizer of Cancer Cells to Low Doses of Paclitaxel by França, Fábio, Silva, Patrícia M A, Soares, José X, Henriques, Ana C, Loureiro, Daniela R P, Azevedo, Carlos M G, Afonso, Carlos M M, Bousbaa, Hassan

“…Microtubule-targeting agents (MTAs) remain a gold standard for the treatment of several cancer types. By interfering with microtubules dynamic, MTAs induce a…”
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